FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2969661570> ?p ?o ?g. }

• W2969661570 endingPage "e0221650" @default.
• W2969661570 startingPage "e0221650" @default.
• W2969661570 abstract "Several reports indicate crosstalk between the transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2) and estrogen, which has a protective effect in colorectal cancer (CRC). The aim of this study was to investigate the role of Nrf2 signaling in the anti-inflammatory effect of estrogen using Nrf2 knockout (Nrf2 KO) mouse embryonic fibroblasts (MEFs), a powerful system to test the function of target genes due to their easy accessibility, and rapid growth rates. After inducing inflammation by tumor necrosis factor alpha (TNF-α), the effects of 17β-estradiol (E2) on the expression of proinflammatory mediators [i.e., NF-κB and inducible nitric oxide synthase (iNOS)] and estrogen receptors were evaluated by Western blot. In wild type (WT) MEFs, E2 treatment ameliorated TNF-α-induced nuclear translocation of NF-κB and expression of its target protein iNOS. Estrogen receptor beta (ERβ) expression was decreased by TNF-α-induced inflammation and restored by E2 treatment. When treated to WT MEFs, E2 induced nuclear translocation of Nrf2. The inhibitory effect of E2 on TNF-α-induced enhancement of iNOS was markedly dampened in Nrf2 KO MEFs. Notably, ERβ expression was significantly diminished in Nrf2 KO MEFs compared to that in WT cells. Promoter Database (EPD) revealed two putative anti-oxidant response elements (AREs) within the mouse ERβ promoter. Furthermore, in WT MEFs, E2 treatment repressed TNF-α-induced expression of iNOS protein and recovered by 4-(2-phenyl-5,7-bis(trifluoromethyl)pyrazolo(1,5-a)pyrimidin-3-yl)phenol (PHTPP), a selective ERβ antagonist, treatment, but not in Nrf2 KO MEFs. In conclusion, Nrf2 plays a pivotal role in the anti-inflammatory of estrogen by direct regulating the expression of ERβ." @default.
• W2969661570 created "2019-08-29" @default.
• W2969661570 creator A5001402338 @default.
• W2969661570 creator A5019256390 @default.
• W2969661570 creator A5042416221 @default.
• W2969661570 creator A5047996963 @default.
• W2969661570 creator A5076533456 @default.
• W2969661570 date "2019-08-23" @default.
• W2969661570 modified "2023-10-01" @default.
• W2969661570 title "17-β estradiol exerts anti-inflammatory effects through activation of Nrf2 in mouse embryonic fibroblasts" @default.
• W2969661570 cites W1508323668 @default.
• W2969661570 cites W1561096292 @default.
• W2969661570 cites W1592051611 @default.
• W2969661570 cites W1726588509 @default.
• W2969661570 cites W1978018545 @default.
• W2969661570 cites W1986364810 @default.
• W2969661570 cites W1987869112 @default.
• W2969661570 cites W2011026204 @default.
• W2969661570 cites W2015243552 @default.
• W2969661570 cites W2027085316 @default.
• W2969661570 cites W2027424508 @default.
• W2969661570 cites W2032347563 @default.
• W2969661570 cites W2037839678 @default.
• W2969661570 cites W2043550686 @default.
• W2969661570 cites W2045688706 @default.
• W2969661570 cites W2045821670 @default.
• W2969661570 cites W2048792427 @default.
• W2969661570 cites W2053889157 @default.
• W2969661570 cites W2058520274 @default.
• W2969661570 cites W2060198845 @default.
• W2969661570 cites W2061434349 @default.
• W2969661570 cites W2063165012 @default.
• W2969661570 cites W2072424063 @default.
• W2969661570 cites W2073704436 @default.
• W2969661570 cites W2073883348 @default.
• W2969661570 cites W2087669579 @default.
• W2969661570 cites W2090335342 @default.
• W2969661570 cites W2096401930 @default.
• W2969661570 cites W2113971187 @default.
• W2969661570 cites W2117959909 @default.
• W2969661570 cites W2123970448 @default.
• W2969661570 cites W2135919238 @default.
• W2969661570 cites W2136541538 @default.
• W2969661570 cites W2148114118 @default.
• W2969661570 cites W2153005316 @default.
• W2969661570 cites W2159203244 @default.
• W2969661570 cites W2160239222 @default.
• W2969661570 cites W2164414963 @default.
• W2969661570 cites W2165643859 @default.
• W2969661570 cites W2266938879 @default.
• W2969661570 cites W2273605374 @default.
• W2969661570 cites W2330030716 @default.
• W2969661570 cites W2400239628 @default.
• W2969661570 cites W2525382275 @default.
• W2969661570 cites W2567552955 @default.
• W2969661570 cites W2770178180 @default.
• W2969661570 cites W2778768676 @default.
• W2969661570 cites W2780399282 @default.
• W2969661570 cites W2887239928 @default.
• W2969661570 cites W2896283297 @default.
• W2969661570 cites W2900408542 @default.
• W2969661570 cites W2904989507 @default.
• W2969661570 cites W4238891695 @default.
• W2969661570 doi "https://doi.org/10.1371/journal.pone.0221650" @default.
• W2969661570 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6707591" @default.
• W2969661570 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31442293" @default.
• W2969661570 hasPublicationYear "2019" @default.
• W2969661570 type Work @default.
• W2969661570 sameAs 2969661570 @default.
• W2969661570 citedByCount "21" @default.
• W2969661570 countsByYear W29696615702020 @default.
• W2969661570 countsByYear W29696615702021 @default.
• W2969661570 countsByYear W29696615702022 @default.
• W2969661570 countsByYear W29696615702023 @default.
• W2969661570 crossrefType "journal-article" @default.
• W2969661570 hasAuthorship W2969661570A5001402338 @default.
• W2969661570 hasAuthorship W2969661570A5019256390 @default.
• W2969661570 hasAuthorship W2969661570A5042416221 @default.
• W2969661570 hasAuthorship W2969661570A5047996963 @default.
• W2969661570 hasAuthorship W2969661570A5076533456 @default.
• W2969661570 hasBestOaLocation W29696615701 @default.
• W2969661570 hasConcept C104317684 @default.
• W2969661570 hasConcept C121608353 @default.
• W2969661570 hasConcept C126322002 @default.
• W2969661570 hasConcept C134018914 @default.
• W2969661570 hasConcept C153911025 @default.
• W2969661570 hasConcept C164027704 @default.
• W2969661570 hasConcept C172313692 @default.
• W2969661570 hasConcept C17991360 @default.
• W2969661570 hasConcept C185592680 @default.
• W2969661570 hasConcept C203014093 @default.
• W2969661570 hasConcept C2776415932 @default.
• W2969661570 hasConcept C2776914184 @default.
• W2969661570 hasConcept C2777164284 @default.
• W2969661570 hasConcept C2777622882 @default.
• W2969661570 hasConcept C519581460 @default.
• W2969661570 hasConcept C530470458 @default.
• W2969661570 hasConcept C55493867 @default.

• next