FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2969665747> ?p ?o ?g. }

• W2969665747 endingPage "52" @default.
• W2969665747 startingPage "52" @default.
• W2969665747 abstract "Cancer initiation and progression depends on genetic and epigenetic alterations such as DNA methylation and histone modifications. Hypermethylation and deacetylation of the CIP/KIP family (p21, p27, and p57) lead to tumorigenesis. Our previous study indicated that DNA methyltransferase (DNMT) inhibitor and histone deacetylase (HDAC) inhibitors can inhibit cell growth and induce apoptosis. The aim of the present study was to investigate the effect of 5-Aza-2'-deoxycytidine (5-Aza-CdR) in comparison to valproic acid (VPA) and trichostatin A (TSA) on HDAC1, DNMT1, and CIP/KIP family (p21, p27, and p57) genes expression, cell growth inhibition, and apoptosis induction in colon cancer SW480 cell line.The effect of the compounds on the cell viability was measured by MTT assay. The expression of HDAC1, DNMT1, and CIP/KIP family (p21, p27, and p57) genes was evaluated by real-time quantitative reverse transcription-polymerase chain reaction (RT-PCR). For the detection of cell apoptosis, apoptotic cells were examined by the Annexin V-FITC/PI detection kit.The results of MTT assay indicated that 5-Aza-CdR, VPA, and TSA significantly inhibited cell growth (P < 0.002, P < 0.001, and P < 0.001, respectively). The results of real-time RT-PCR demonstrated that all compounds significantly down-regulated DNMT1 and HDAC1, and up-regulated p21, p27, and p57 genes expression. The result of flow cytometry assay revealed that all agents induced apoptosis significantly.5-Aza-CdR, VPA, and TSA can significantly downregulate DNMT1 and HDAC1 and up-regulate p21, p27, and p57 genes expression through which enhance cell apoptosis and cell growth inhibition in colon cancer." @default.
• W2969665747 created "2019-08-29" @default.
• W2969665747 creator A5011549407 @default.
• W2969665747 creator A5013809474 @default.
• W2969665747 date "2019-01-01" @default.
• W2969665747 modified "2023-10-18" @default.
• W2969665747 title "Effect of 5-aza-2'-deoxycytidine in comparison to valproic acid and trichostatin a on histone deacetylase 1, dna methyltransferase 1, and cip/kip family (p21, p27, and p57) genes expression, cell growth inhibition, and apoptosis induction in colon cancer sw480 cell line" @default.
• W2969665747 cites W1522186213 @default.
• W2969665747 cites W1523987158 @default.
• W2969665747 cites W1645404114 @default.
• W2969665747 cites W1840993518 @default.
• W2969665747 cites W1979091496 @default.
• W2969665747 cites W1984207046 @default.
• W2969665747 cites W1987172374 @default.
• W2969665747 cites W1988220701 @default.
• W2969665747 cites W1989203222 @default.
• W2969665747 cites W1993852175 @default.
• W2969665747 cites W2002984897 @default.
• W2969665747 cites W2016292824 @default.
• W2969665747 cites W2038052026 @default.
• W2969665747 cites W2038424386 @default.
• W2969665747 cites W2044303805 @default.
• W2969665747 cites W2046983501 @default.
• W2969665747 cites W2054240721 @default.
• W2969665747 cites W2063823143 @default.
• W2969665747 cites W2066748023 @default.
• W2969665747 cites W2068032512 @default.
• W2969665747 cites W2073345114 @default.
• W2969665747 cites W2092476693 @default.
• W2969665747 cites W2094552440 @default.
• W2969665747 cites W2101909701 @default.
• W2969665747 cites W2106539730 @default.
• W2969665747 cites W2107733280 @default.
• W2969665747 cites W2108743126 @default.
• W2969665747 cites W2114540841 @default.
• W2969665747 cites W2124173308 @default.
• W2969665747 cites W2141631785 @default.
• W2969665747 cites W2144001782 @default.
• W2969665747 cites W2144604118 @default.
• W2969665747 cites W2153106604 @default.
• W2969665747 cites W2160762455 @default.
• W2969665747 cites W2161611303 @default.
• W2969665747 cites W2163288644 @default.
• W2969665747 cites W2164662604 @default.
• W2969665747 cites W2165744338 @default.
• W2969665747 cites W2199488492 @default.
• W2969665747 cites W2228444494 @default.
• W2969665747 cites W2345887121 @default.
• W2969665747 cites W2409867495 @default.
• W2969665747 cites W2488315658 @default.
• W2969665747 cites W2753151068 @default.
• W2969665747 cites W2760903876 @default.
• W2969665747 cites W2772812043 @default.
• W2969665747 cites W2778503620 @default.
• W2969665747 cites W2781101930 @default.
• W2969665747 cites W2784119598 @default.
• W2969665747 cites W2793546958 @default.
• W2969665747 cites W2883458060 @default.
• W2969665747 cites W2911504061 @default.
• W2969665747 doi "https://doi.org/10.4103/abr.abr_91_19" @default.
• W2969665747 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6712896" @default.
• W2969665747 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31516890" @default.
• W2969665747 hasPublicationYear "2019" @default.
• W2969665747 type Work @default.
• W2969665747 sameAs 2969665747 @default.
• W2969665747 citedByCount "24" @default.
• W2969665747 countsByYear W29696657472019 @default.
• W2969665747 countsByYear W29696657472020 @default.
• W2969665747 countsByYear W29696657472021 @default.
• W2969665747 countsByYear W29696657472022 @default.
• W2969665747 countsByYear W29696657472023 @default.
• W2969665747 crossrefType "journal-article" @default.
• W2969665747 hasAuthorship W2969665747A5011549407 @default.
• W2969665747 hasAuthorship W2969665747A5013809474 @default.
• W2969665747 hasBestOaLocation W29696657471 @default.
• W2969665747 hasConcept C104317684 @default.
• W2969665747 hasConcept C150194340 @default.
• W2969665747 hasConcept C153911025 @default.
• W2969665747 hasConcept C175211621 @default.
• W2969665747 hasConcept C185592680 @default.
• W2969665747 hasConcept C190283241 @default.
• W2969665747 hasConcept C190727270 @default.
• W2969665747 hasConcept C2776202225 @default.
• W2969665747 hasConcept C2777865847 @default.
• W2969665747 hasConcept C2778305200 @default.
• W2969665747 hasConcept C2779979206 @default.
• W2969665747 hasConcept C2780783641 @default.
• W2969665747 hasConcept C29537977 @default.
• W2969665747 hasConcept C33288867 @default.
• W2969665747 hasConcept C41091548 @default.
• W2969665747 hasConcept C502942594 @default.
• W2969665747 hasConcept C53227056 @default.
• W2969665747 hasConcept C55493867 @default.
• W2969665747 hasConcept C62112901 @default.
• W2969665747 hasConcept C64927066 @default.
• W2969665747 hasConcept C86803240 @default.
• W2969665747 hasConcept C91965660 @default.
• W2969665747 hasConceptScore W2969665747C104317684 @default.

• next