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• W2969670076 abstract "Abstract While splicing has been shown to enhance nuclear export, it has remained unclear whether mRNAs generated from intronless genes use specific machinery to promote their export. Here we investigate the role of the major nuclear pore basket protein, TPR, in regulating mRNA and lncRNA nuclear export in human cells. By sequencing mRNA from the nucleus and cytosol of control and TPR-depleted cells, we provide evidence that TPR is required for the nuclear export of mRNAs and lncRNAs that are generated from intronless and intron-poor genes, and we validate this with reporter constructs. Moreover, in TPR-depleted cells reporter mRNAs generated from intronless genes accumulate in nuclear speckles and are bound to Nxf1. These observations suggest that TPR acts downstream of Nxf1 recruitment, and may allow mRNAs to leave nuclear speckles and properly dock with the nuclear pore. In summary, our study provides one of the first examples of a factor that is required for the nuclear export of intronless and intron-poor mRNAs and lncRNAs." @default.
• W2969670076 created "2019-08-29" @default.
• W2969670076 creator A5013107243 @default.
• W2969670076 creator A5015634791 @default.
• W2969670076 creator A5056346829 @default.
• W2969670076 creator A5069097393 @default.
• W2969670076 creator A5076978787 @default.
• W2969670076 date "2019-08-20" @default.
• W2969670076 modified "2023-09-27" @default.
• W2969670076 title "TPR is required for the nuclear export of mRNAs and lncRNAs from intronless and intron-poor genes" @default.
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• W2969670076 doi "https://doi.org/10.1101/740498" @default.
• W2969670076 hasPublicationYear "2019" @default.
• W2969670076 type Work @default.
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