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• W2969671405 abstract "The formation of a membrane-enveloped virus starts with the assembly of a curved layer of capsid proteins lining the interior of the plasma membrane (PM) of the host cell. This layer develops into a spherical shell (capsid) enveloped by a lipid-rich membrane. In many cases, the budding process stalls prior to the release of the virus. Recently, Brownian dynamics simulations of a coarse-grained model system reproduced protracted pausing and stalling, which suggests that the origin of pausing/stalling is to be found in the physics of the budding process. Here, we propose that the pausing/stalling observed in the simulations can be understood as a purely kinetic phenomenon associated with the neck geometry. A geometrical potential energy barrier develops during the budding that must be overcome by capsid proteins diffusing along the membrane prior to incorporation into the capsid. The barrier is generated by a conflict between the positive Gauss curvature of the assembling capsid and the negative Gauss curvature of the neck region. A continuum theory description is proposed and is compared with the Brownian simulations of the budding of enveloped viruses." @default.
• W2969671405 created "2019-08-29" @default.
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• W2969671405 date "2019-08-21" @default.
• W2969671405 modified "2023-10-18" @default.
• W2969671405 title "Gaussian curvature and the budding kinetics of enveloped viruses" @default.
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• W2969671405 doi "https://doi.org/10.1371/journal.pcbi.1006602" @default.
• W2969671405 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6736314" @default.
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