FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2969678045> ?p ?o ?g. }

• W2969678045 abstract "Overactive bladder (OAB) is mostly observed in obese individuals, and is associated with enhanced excitability and contractility of the detrusor smooth muscle (DSM). Large-conductance voltage- and Ca2+-activated K+ (BK) channels reduce the excitability and contractility of the DSM. We tested whether obesity-induced OAB is associated with altered BK channel expression and activity in the DSM. Seven-week-old female Sprague-Dawley rats (N=80) were fed a normal or high-fat diet (HFD) for 12 weeks. HFD-fed rats exhibited a higher average bodyweight and urodynamically established detrusor overactivity. mRNA levels of the Kcnma1 (BKα subunit) and Kcnmb1 (BKβ1 subunit) in whole tissues and cells from the DSM were reduced in HFD-fed rats. A selective BK channel opener, NS1619, was then applied to DSM cells from the two groups of rats. Patch-clamp techniques revealed that spontaneous transient outward currents, NS1619-induced activation of spontaneous transient outward currents, and whole-cell BK currents, as well as NS1619-induced membrane hyperpolarization, were attenuated in DSM cells from HFD-fed rats. The relaxation effect of NS1619 on contractility was reduced in DSM strips from HFD-fed rats. Thus, impaired expression of Kcnma1 and Kcnmb1 in the DSM contributes to obesity-induced OAB, suggesting that BK channels could be a useful treatment targets in OAB." @default.
• W2969678045 created "2019-08-29" @default.
• W2969678045 creator A5001552629 @default.
• W2969678045 creator A5029360035 @default.
• W2969678045 creator A5031810848 @default.
• W2969678045 creator A5062848020 @default.
• W2969678045 creator A5065508042 @default.
• W2969678045 creator A5072571039 @default.
• W2969678045 date "2019-08-21" @default.
• W2969678045 modified "2023-10-16" @default.
• W2969678045 title "Attenuated BK channel function promotes overactive bladder in a rat model of obesity" @default.
• W2969678045 cites W1482585622 @default.
• W2969678045 cites W1496730963 @default.
• W2969678045 cites W156625477 @default.
• W2969678045 cites W1701982621 @default.
• W2969678045 cites W1748265667 @default.
• W2969678045 cites W1967023268 @default.
• W2969678045 cites W1977784818 @default.
• W2969678045 cites W198624498 @default.
• W2969678045 cites W1995503637 @default.
• W2969678045 cites W2015756407 @default.
• W2969678045 cites W2028685707 @default.
• W2969678045 cites W2035740875 @default.
• W2969678045 cites W2041576208 @default.
• W2969678045 cites W2042594308 @default.
• W2969678045 cites W2047785533 @default.
• W2969678045 cites W2048859899 @default.
• W2969678045 cites W2050441306 @default.
• W2969678045 cites W2067023638 @default.
• W2969678045 cites W2075058896 @default.
• W2969678045 cites W2085238920 @default.
• W2969678045 cites W2085548554 @default.
• W2969678045 cites W2094950759 @default.
• W2969678045 cites W2096171748 @default.
• W2969678045 cites W2103276404 @default.
• W2969678045 cites W2106765734 @default.
• W2969678045 cites W2112827709 @default.
• W2969678045 cites W2120208564 @default.
• W2969678045 cites W2122930170 @default.
• W2969678045 cites W2131173377 @default.
• W2969678045 cites W2138665941 @default.
• W2969678045 cites W2138914271 @default.
• W2969678045 cites W2147647029 @default.
• W2969678045 cites W2163996138 @default.
• W2969678045 cites W2164052170 @default.
• W2969678045 cites W2166545601 @default.
• W2969678045 cites W2167148189 @default.
• W2969678045 cites W2170081416 @default.
• W2969678045 cites W2285629360 @default.
• W2969678045 cites W2288484083 @default.
• W2969678045 cites W2298418357 @default.
• W2969678045 cites W2402854501 @default.
• W2969678045 cites W2553913378 @default.
• W2969678045 cites W2606763983 @default.
• W2969678045 cites W2611034753 @default.
• W2969678045 cites W2740706170 @default.
• W2969678045 cites W2792204325 @default.
• W2969678045 cites W2898494923 @default.
• W2969678045 cites W2930491556 @default.
• W2969678045 cites W2942655329 @default.
• W2969678045 cites W4246062846 @default.
• W2969678045 doi "https://doi.org/10.18632/aging.102182" @default.
• W2969678045 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6738405" @default.
• W2969678045 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31480021" @default.
• W2969678045 hasPublicationYear "2019" @default.
• W2969678045 type Work @default.
• W2969678045 sameAs 2969678045 @default.
• W2969678045 citedByCount "6" @default.
• W2969678045 countsByYear W29696780452020 @default.
• W2969678045 countsByYear W29696780452021 @default.
• W2969678045 countsByYear W29696780452022 @default.
• W2969678045 crossrefType "journal-article" @default.
• W2969678045 hasAuthorship W2969678045A5001552629 @default.
• W2969678045 hasAuthorship W2969678045A5029360035 @default.
• W2969678045 hasAuthorship W2969678045A5031810848 @default.
• W2969678045 hasAuthorship W2969678045A5062848020 @default.
• W2969678045 hasAuthorship W2969678045A5065508042 @default.
• W2969678045 hasAuthorship W2969678045A5072571039 @default.
• W2969678045 hasBestOaLocation W29696780451 @default.
• W2969678045 hasConcept C126322002 @default.
• W2969678045 hasConcept C131453863 @default.
• W2969678045 hasConcept C134018914 @default.
• W2969678045 hasConcept C142724271 @default.
• W2969678045 hasConcept C147944092 @default.
• W2969678045 hasConcept C178790620 @default.
• W2969678045 hasConcept C185263204 @default.
• W2969678045 hasConcept C185592680 @default.
• W2969678045 hasConcept C204787440 @default.
• W2969678045 hasConcept C2778941218 @default.
• W2969678045 hasConcept C39133596 @default.
• W2969678045 hasConcept C61144316 @default.
• W2969678045 hasConcept C66974803 @default.
• W2969678045 hasConcept C71924100 @default.
• W2969678045 hasConcept C83743174 @default.
• W2969678045 hasConceptScore W2969678045C126322002 @default.
• W2969678045 hasConceptScore W2969678045C131453863 @default.
• W2969678045 hasConceptScore W2969678045C134018914 @default.
• W2969678045 hasConceptScore W2969678045C142724271 @default.
• W2969678045 hasConceptScore W2969678045C147944092 @default.
• W2969678045 hasConceptScore W2969678045C178790620 @default.

• next