Matches in SemOpenAlex for { <https://semopenalex.org/work/W2969688603> ?p ?o ?g. }
- W2969688603 endingPage "54" @default.
- W2969688603 startingPage "47" @default.
- W2969688603 abstract "Particulate matter with a diameter of less than 2.5 μm (PM2.5) easily deposits on lung alveoli and degrades human health. Surfactant protein A (SP-A) is the most abundant pulmonary surfactant protein stored in lamellar bodies (LBs) of alveolar epithelial type II cells. The impacts of PM2.5 on SP-A are multifaceted and intractable, and the underlying mechanism remains unclear. In this study, the expression and distribution of SP-A in Balb/c mice and A549 cells under PM2.5 exposure were investigated. The results showed that the low and medium concentration of PM2.5 gradually enhanced SP-A protein and mRNA expression, whereas the high concentration of PM2.5 conspicuously decreased SP-A protein but not its mRNA compared with the control. The trafficking of SP-A to LBs was gradually disturbed, and concomitantly, the lesions of LBs responsible for the transport and storage of SP-A protein were exacerbated with increased PM2.5 concentration. Reactive oxygen species production abundantly increased upon PM2.5 exposure, and it was antagonized by the oxidant inhibitor N-acetylcysteine. Subsequently, the injured LBs and the decrease in SP-A expression under exposure to the high concentration of PM2.5 were well rescued. The present study provides a new perspective to investigate the adverse effects of PM2.5 or diesel exhaust particles on other proteins transported to and stored in LBs." @default.
- W2969688603 created "2019-08-29" @default.
- W2969688603 creator A5001877165 @default.
- W2969688603 creator A5023420879 @default.
- W2969688603 creator A5025088153 @default.
- W2969688603 creator A5027488753 @default.
- W2969688603 creator A5028285965 @default.
- W2969688603 creator A5044298085 @default.
- W2969688603 creator A5050947857 @default.
- W2969688603 creator A5053195007 @default.
- W2969688603 creator A5053417146 @default.
- W2969688603 creator A5054078288 @default.
- W2969688603 creator A5074102139 @default.
- W2969688603 creator A5074208581 @default.
- W2969688603 creator A5075690648 @default.
- W2969688603 creator A5076559445 @default.
- W2969688603 creator A5085534284 @default.
- W2969688603 date "2019-10-01" @default.
- W2969688603 modified "2023-10-15" @default.
- W2969688603 title "Adverse impact of ambient PM2.5 on expression and trafficking of surfactant protein A through reactive oxygen species damage to lamellar bodies" @default.
- W2969688603 cites W1177074592 @default.
- W2969688603 cites W1181131154 @default.
- W2969688603 cites W2005792051 @default.
- W2969688603 cites W2012221646 @default.
- W2969688603 cites W2026738415 @default.
- W2969688603 cites W2029708200 @default.
- W2969688603 cites W2051965749 @default.
- W2969688603 cites W2063345075 @default.
- W2969688603 cites W2086993280 @default.
- W2969688603 cites W2089625849 @default.
- W2969688603 cites W2100472018 @default.
- W2969688603 cites W2108068788 @default.
- W2969688603 cites W2114362347 @default.
- W2969688603 cites W2139644134 @default.
- W2969688603 cites W2161236807 @default.
- W2969688603 cites W2161723325 @default.
- W2969688603 cites W2166899266 @default.
- W2969688603 cites W2296439643 @default.
- W2969688603 cites W2338657098 @default.
- W2969688603 cites W2406904044 @default.
- W2969688603 cites W2537977245 @default.
- W2969688603 cites W2563993762 @default.
- W2969688603 cites W2792510363 @default.
- W2969688603 cites W2795630832 @default.
- W2969688603 cites W2796022561 @default.
- W2969688603 cites W2883951072 @default.
- W2969688603 cites W2912447847 @default.
- W2969688603 cites W2946495548 @default.
- W2969688603 doi "https://doi.org/10.1016/j.toxlet.2019.08.015" @default.
- W2969688603 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31449845" @default.
- W2969688603 hasPublicationYear "2019" @default.
- W2969688603 type Work @default.
- W2969688603 sameAs 2969688603 @default.
- W2969688603 citedByCount "9" @default.
- W2969688603 countsByYear W29696886032020 @default.
- W2969688603 countsByYear W29696886032021 @default.
- W2969688603 countsByYear W29696886032022 @default.
- W2969688603 countsByYear W29696886032023 @default.
- W2969688603 crossrefType "journal-article" @default.
- W2969688603 hasAuthorship W2969688603A5001877165 @default.
- W2969688603 hasAuthorship W2969688603A5023420879 @default.
- W2969688603 hasAuthorship W2969688603A5025088153 @default.
- W2969688603 hasAuthorship W2969688603A5027488753 @default.
- W2969688603 hasAuthorship W2969688603A5028285965 @default.
- W2969688603 hasAuthorship W2969688603A5044298085 @default.
- W2969688603 hasAuthorship W2969688603A5050947857 @default.
- W2969688603 hasAuthorship W2969688603A5053195007 @default.
- W2969688603 hasAuthorship W2969688603A5053417146 @default.
- W2969688603 hasAuthorship W2969688603A5054078288 @default.
- W2969688603 hasAuthorship W2969688603A5074102139 @default.
- W2969688603 hasAuthorship W2969688603A5074208581 @default.
- W2969688603 hasAuthorship W2969688603A5075690648 @default.
- W2969688603 hasAuthorship W2969688603A5076559445 @default.
- W2969688603 hasAuthorship W2969688603A5085534284 @default.
- W2969688603 hasConcept C104317684 @default.
- W2969688603 hasConcept C105580179 @default.
- W2969688603 hasConcept C126322002 @default.
- W2969688603 hasConcept C145156650 @default.
- W2969688603 hasConcept C1491633281 @default.
- W2969688603 hasConcept C153911025 @default.
- W2969688603 hasConcept C178790620 @default.
- W2969688603 hasConcept C185592680 @default.
- W2969688603 hasConcept C2777714996 @default.
- W2969688603 hasConcept C48349386 @default.
- W2969688603 hasConcept C540031477 @default.
- W2969688603 hasConcept C55493867 @default.
- W2969688603 hasConcept C58226133 @default.
- W2969688603 hasConcept C6856738 @default.
- W2969688603 hasConcept C71924100 @default.
- W2969688603 hasConcept C77851909 @default.
- W2969688603 hasConcept C8010536 @default.
- W2969688603 hasConcept C81729549 @default.
- W2969688603 hasConcept C86803240 @default.
- W2969688603 hasConcept C95444343 @default.
- W2969688603 hasConceptScore W2969688603C104317684 @default.
- W2969688603 hasConceptScore W2969688603C105580179 @default.
- W2969688603 hasConceptScore W2969688603C126322002 @default.
- W2969688603 hasConceptScore W2969688603C145156650 @default.