Matches in SemOpenAlex for { <https://semopenalex.org/work/W2969702364> ?p ?o ?g. }
- W2969702364 endingPage "386" @default.
- W2969702364 startingPage "376" @default.
- W2969702364 abstract "To evaluate outcomes of patients treated with intensive intravitreal therapy and to describe the evolution of quantitative real-time polymerase chain reaction (qPCR) in patients treated for acute retinal necrosis (ARN) syndrome.Retrospective observational case series.This study included 25 eyes of 24 patients with ARN who were treated and followed up in 2 departments of ophthalmology in Lyon, France. Assessed outcomes included qPCR viral load profile during treatment, number of antiviral intravitreal injections (IVT), retinal detachment rate, and best-corrected visual acuity.Final visual acuity was 20/200 or less in 20% of cases; the rate of retinal detachment was 16%. Viral load kinetics changed in 3 phases: a first plateau period that was not consistent, a logarithmic decrease phase, and a negativation phase. Mean decay of the logarithm of the viral load was estimated at 0.076 per day; mean time of negativation was 56.1 days. Median IVT number was 9 (range, 0-28). Ten patients were treated with injections until the viral load was undetectable. Resistance to acyclovir was observed in a patient with a prolonged initial plateau of the viral load.Numerous and prolonged IVTs, used as adjunctive therapy, could improve the prognosis of treated patients by decreasing the risk of retinal detachment and improving visual acuity. QPCR enables monitoring of the response to treatment and can provide evidence for resistance to antiviral treatment by enabling the detection of cases with a prolonged initial plateau of viral load." @default.
- W2969702364 created "2019-08-29" @default.
- W2969702364 creator A5010133050 @default.
- W2969702364 creator A5024581043 @default.
- W2969702364 creator A5031143082 @default.
- W2969702364 creator A5046227059 @default.
- W2969702364 creator A5053553560 @default.
- W2969702364 creator A5055987612 @default.
- W2969702364 creator A5064408268 @default.
- W2969702364 creator A5064668489 @default.
- W2969702364 creator A5071952706 @default.
- W2969702364 date "2019-12-01" @default.
- W2969702364 modified "2023-10-09" @default.
- W2969702364 title "Acute Retinal Necrosis: Virological Features Using Quantitative Polymerase Chain Reaction, Therapeutic Management, and Clinical Outcomes" @default.
- W2969702364 cites W187490719 @default.
- W2969702364 cites W1949880033 @default.
- W2969702364 cites W1964467510 @default.
- W2969702364 cites W1969697379 @default.
- W2969702364 cites W1975216888 @default.
- W2969702364 cites W1977475484 @default.
- W2969702364 cites W1980624323 @default.
- W2969702364 cites W1983204414 @default.
- W2969702364 cites W1988454028 @default.
- W2969702364 cites W1989464120 @default.
- W2969702364 cites W1991553103 @default.
- W2969702364 cites W2005827830 @default.
- W2969702364 cites W2017249257 @default.
- W2969702364 cites W2029038649 @default.
- W2969702364 cites W2032114564 @default.
- W2969702364 cites W2035147249 @default.
- W2969702364 cites W2036952698 @default.
- W2969702364 cites W2037115374 @default.
- W2969702364 cites W2037732815 @default.
- W2969702364 cites W2038583218 @default.
- W2969702364 cites W2039852137 @default.
- W2969702364 cites W2043856108 @default.
- W2969702364 cites W2050612035 @default.
- W2969702364 cites W2057304061 @default.
- W2969702364 cites W2058550722 @default.
- W2969702364 cites W2058907138 @default.
- W2969702364 cites W2060035923 @default.
- W2969702364 cites W2064587156 @default.
- W2969702364 cites W2065825362 @default.
- W2969702364 cites W2066297192 @default.
- W2969702364 cites W2070065804 @default.
- W2969702364 cites W2072201298 @default.
- W2969702364 cites W2072220307 @default.
- W2969702364 cites W2080088218 @default.
- W2969702364 cites W2083156480 @default.
- W2969702364 cites W2087950464 @default.
- W2969702364 cites W2091051985 @default.
- W2969702364 cites W2095414632 @default.
- W2969702364 cites W2099017352 @default.
- W2969702364 cites W2103098707 @default.
- W2969702364 cites W2105066207 @default.
- W2969702364 cites W2106520317 @default.
- W2969702364 cites W2117268035 @default.
- W2969702364 cites W2120689434 @default.
- W2969702364 cites W2125185171 @default.
- W2969702364 cites W2145538526 @default.
- W2969702364 cites W2146234604 @default.
- W2969702364 cites W2149842352 @default.
- W2969702364 cites W2167947784 @default.
- W2969702364 cites W2171291942 @default.
- W2969702364 cites W2296627934 @default.
- W2969702364 cites W2313102412 @default.
- W2969702364 cites W2405525258 @default.
- W2969702364 cites W2407231743 @default.
- W2969702364 cites W2515342453 @default.
- W2969702364 cites W2612683546 @default.
- W2969702364 doi "https://doi.org/10.1016/j.ajo.2019.08.007" @default.
- W2969702364 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31449790" @default.
- W2969702364 hasPublicationYear "2019" @default.
- W2969702364 type Work @default.
- W2969702364 sameAs 2969702364 @default.
- W2969702364 citedByCount "25" @default.
- W2969702364 countsByYear W29697023642020 @default.
- W2969702364 countsByYear W29697023642021 @default.
- W2969702364 countsByYear W29697023642022 @default.
- W2969702364 countsByYear W29697023642023 @default.
- W2969702364 crossrefType "journal-article" @default.
- W2969702364 hasAuthorship W2969702364A5010133050 @default.
- W2969702364 hasAuthorship W2969702364A5024581043 @default.
- W2969702364 hasAuthorship W2969702364A5031143082 @default.
- W2969702364 hasAuthorship W2969702364A5046227059 @default.
- W2969702364 hasAuthorship W2969702364A5053553560 @default.
- W2969702364 hasAuthorship W2969702364A5055987612 @default.
- W2969702364 hasAuthorship W2969702364A5064408268 @default.
- W2969702364 hasAuthorship W2969702364A5064668489 @default.
- W2969702364 hasAuthorship W2969702364A5071952706 @default.
- W2969702364 hasBestOaLocation W29697023641 @default.
- W2969702364 hasConcept C104317684 @default.
- W2969702364 hasConcept C118487528 @default.
- W2969702364 hasConcept C141071460 @default.
- W2969702364 hasConcept C142462285 @default.
- W2969702364 hasConcept C159047783 @default.
- W2969702364 hasConcept C167135981 @default.
- W2969702364 hasConcept C2522874641 @default.