Matches in SemOpenAlex for { <https://semopenalex.org/work/W2969720632> ?p ?o ?g. }
- W2969720632 endingPage "1967" @default.
- W2969720632 startingPage "1967" @default.
- W2969720632 abstract "Oligosaccharides (OS) are commonly added to infant formulas, however, their physiological impact, particularly on adult health programming, is poorly described. In adult animals, OS modify microbiota and stimulate colonic fermentation and enteroendocrine cell (EEC) activity. Since neonatal changes in microbiota and/or EEC density could be long-lasting and EEC-derived peptides do regulate short-term food intake, we hypothesized that neonatal OS consumption could modulate early EECs, with possible consequences for adult eating behavior. Suckling rats were supplemented with fructo-oligosaccharides (FOS), beta-galacto-oligosaccharides/inulin (GOS/In) mix, alpha-galacto-oligosaccharides (αGOS) at 3.2 g/kg, or a control solution (CTL) between postnatal day (PND) 5 and 14/15. Pups were either sacrificed at PND14/15 or weaned at PND21 onto standard chow. The effects on both microbiota and EEC were characterized at PND14/15, and eating behavior at adulthood. Very early OS supplementation drastically impacted the intestinal environment, endocrine lineage proliferation/differentiation particularly in the ileum, and the density of GLP-1 cells and production of satiety-related peptides (GLP-1 and PYY) in the neonatal period. However, it failed to induce any significant lasting changes on intestinal microbiota, enteropeptide secretion or eating behavior later in life. Overall, the results did not demonstrate any OS programming effect on satiety peptides secreted by L-cells or on food consumption, an observation which is a reassuring outlook from a human perspective." @default.
- W2969720632 created "2019-08-29" @default.
- W2969720632 creator A5014492397 @default.
- W2969720632 creator A5017757363 @default.
- W2969720632 creator A5021381524 @default.
- W2969720632 creator A5024031321 @default.
- W2969720632 creator A5025836387 @default.
- W2969720632 creator A5026227606 @default.
- W2969720632 creator A5044026624 @default.
- W2969720632 creator A5061310332 @default.
- W2969720632 creator A5091263649 @default.
- W2969720632 date "2019-08-21" @default.
- W2969720632 modified "2023-10-18" @default.
- W2969720632 title "Neonatal Consumption of Oligosaccharides Greatly Increases L-Cell Density without Significant Consequence for Adult Eating Behavior" @default.
- W2969720632 cites W1832474145 @default.
- W2969720632 cites W1925956910 @default.
- W2969720632 cites W1972768952 @default.
- W2969720632 cites W1978510451 @default.
- W2969720632 cites W1979433345 @default.
- W2969720632 cites W1991647353 @default.
- W2969720632 cites W2002610656 @default.
- W2969720632 cites W2025552307 @default.
- W2969720632 cites W2027752015 @default.
- W2969720632 cites W2033109439 @default.
- W2969720632 cites W2034061390 @default.
- W2969720632 cites W2034487300 @default.
- W2969720632 cites W2053862932 @default.
- W2969720632 cites W2058124071 @default.
- W2969720632 cites W2062636052 @default.
- W2969720632 cites W2067066432 @default.
- W2969720632 cites W2073544687 @default.
- W2969720632 cites W2080283023 @default.
- W2969720632 cites W2083119809 @default.
- W2969720632 cites W2088697466 @default.
- W2969720632 cites W2090887010 @default.
- W2969720632 cites W2093393589 @default.
- W2969720632 cites W2093829386 @default.
- W2969720632 cites W2094138113 @default.
- W2969720632 cites W2094880019 @default.
- W2969720632 cites W2099460147 @default.
- W2969720632 cites W2105786204 @default.
- W2969720632 cites W2106348916 @default.
- W2969720632 cites W2113707020 @default.
- W2969720632 cites W2125752012 @default.
- W2969720632 cites W2135301093 @default.
- W2969720632 cites W2137216702 @default.
- W2969720632 cites W2137497077 @default.
- W2969720632 cites W2137881103 @default.
- W2969720632 cites W2138411980 @default.
- W2969720632 cites W2139583637 @default.
- W2969720632 cites W2139884694 @default.
- W2969720632 cites W2141318007 @default.
- W2969720632 cites W2142741601 @default.
- W2969720632 cites W2144871388 @default.
- W2969720632 cites W2148051999 @default.
- W2969720632 cites W2148248504 @default.
- W2969720632 cites W2148375127 @default.
- W2969720632 cites W2153075279 @default.
- W2969720632 cites W2162236808 @default.
- W2969720632 cites W2163741486 @default.
- W2969720632 cites W2168842536 @default.
- W2969720632 cites W2169578832 @default.
- W2969720632 cites W2196017803 @default.
- W2969720632 cites W2205656408 @default.
- W2969720632 cites W2206558394 @default.
- W2969720632 cites W2271849037 @default.
- W2969720632 cites W2324326866 @default.
- W2969720632 cites W2342540743 @default.
- W2969720632 cites W2344877030 @default.
- W2969720632 cites W2387324893 @default.
- W2969720632 cites W2417777372 @default.
- W2969720632 cites W2523352558 @default.
- W2969720632 cites W2563081867 @default.
- W2969720632 cites W2571672934 @default.
- W2969720632 cites W2586054043 @default.
- W2969720632 cites W2590245531 @default.
- W2969720632 cites W2602243360 @default.
- W2969720632 cites W2604532633 @default.
- W2969720632 cites W2607034253 @default.
- W2969720632 cites W2607396707 @default.
- W2969720632 cites W2625007078 @default.
- W2969720632 cites W2727159549 @default.
- W2969720632 cites W2735408804 @default.
- W2969720632 cites W2739430696 @default.
- W2969720632 cites W2755234532 @default.
- W2969720632 cites W2765733390 @default.
- W2969720632 cites W2769977587 @default.
- W2969720632 cites W2774551105 @default.
- W2969720632 cites W2781627604 @default.
- W2969720632 cites W2782804646 @default.
- W2969720632 cites W2790707851 @default.
- W2969720632 cites W2838836163 @default.
- W2969720632 cites W2883907811 @default.
- W2969720632 cites W2897066677 @default.
- W2969720632 cites W2912913685 @default.
- W2969720632 cites W2921196477 @default.
- W2969720632 doi "https://doi.org/10.3390/nu11091967" @default.
- W2969720632 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6769936" @default.