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• W2969767547 endingPage "101541" @default.
• W2969767547 startingPage "101541" @default.
• W2969767547 abstract "Tauopathies are a class of neurodegenerative diseases characterized by the presence of pathological intracellular deposits of Tau proteins. Six isoforms of Tau are expressed in the adult human brain, resulting from alternative splicing of the MAPT gene. Tau splicing is developmentally regulated such that only the smallest Tau isoform is expressed in fetal brain, contrary to the adult brain showing the expression of all 6 isoforms. Induced Pluripotent Stem Cell (iPSC) technology has opened up new perspectives in human disease modeling, including tauopathies. However, a major challenge to in vitro recapitulation of Tau pathology in iPSC-derived neurons is their relative immaturity. In this study, we examined the switch in Tau splicing from fetal-only to all adult Tau isoforms during the differentiation of iPSC-derived neurons in a new 3D culture system. First, we showed that iPSC-induced neurons inside Matrigel-coated alginate capsules were able to differentiate into cortical neurons. Then, using a new assay that allowed both the qualitative and the quantitative analysis of all adult MAPT mRNA isoforms individually, we demonstrated that BrainPhys-maintained neurons expressed the 6 adult MAPT mRNA transcripts from 25 weeks of maturation, making this model highly suitable for modeling Tau pathology and therapeutic purposes." @default.
• W2969767547 created "2019-08-29" @default.
• W2969767547 creator A5021709517 @default.
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• W2969767547 date "2019-10-01" @default.
• W2969767547 modified "2023-10-18" @default.
• W2969767547 title "Detection of all adult Tau isoforms in a 3D culture model of iPSC-derived neurons" @default.
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• W2969767547 doi "https://doi.org/10.1016/j.scr.2019.101541" @default.
• W2969767547 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31522011" @default.
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