Matches in SemOpenAlex for { <https://semopenalex.org/work/W2969771230> ?p ?o ?g. }
- W2969771230 abstract "Major depressive disorder (MDD) is a common and disabling syndrome with multiple etiologies that is defined by clinically elicited signs and symptoms. In hopes of developing a list of candidate biological measures that reflect and relate closely to the severity of depressive symptoms, so-called state-dependent biomarkers of depression, this pilot study explored the biochemical underpinnings of treatment response to cognitive behavior therapy (CBT) in medication-freeMDD outpatients. Plasma samples were collected at baseline and week 12 from a subset of MDD patients (N=26) who completed a course of CBT treatment as part of the Predictors of Remission in Depression to Individual and Combined Treatments (PReDICT) study. Targeted metabolomic profiling using the the AbsoluteIDQ® p180 Kit and LC-MS identified eight co-expressed metabolomic modules. Of these eight, three were significantly associated with change in depressive symptoms over the course of the 12-weeks. Metabolites found to be most strongly correlated with change in depressive symptoms were branched chain amino acids, acylcarnitines, methionine sulfoxide, and α-aminoadipic acid (negative correlations with symptom change) as well as several lipids, particularly the phosphatidlylcholines (positive correlation). These results implicate disturbed bioenergetics as an important state marker in the pathobiology of MDD. Exploratory analyses contrasting remitters to CBT versus those who failed the treatment further suggest these metabolites may serve as mediators of recovery during CBT treatment. Larger studies examining metabolomic change patterns in patients treated with pharmacotherapy or psychotherapy will be necessary to elucidate the biological underpinnings of MDD and the -specific biologies of treatment response." @default.
- W2969771230 created "2019-08-29" @default.
- W2969771230 creator A5005712710 @default.
- W2969771230 creator A5015972818 @default.
- W2969771230 creator A5022104848 @default.
- W2969771230 creator A5025091889 @default.
- W2969771230 creator A5026199142 @default.
- W2969771230 creator A5029433360 @default.
- W2969771230 creator A5056312367 @default.
- W2969771230 creator A5056637382 @default.
- W2969771230 creator A5061744695 @default.
- W2969771230 creator A5072914653 @default.
- W2969771230 creator A5078348766 @default.
- W2969771230 creator A5090955632 @default.
- W2969771230 date "2019-09-12" @default.
- W2969771230 modified "2023-10-03" @default.
- W2969771230 title "Pilot Study of Metabolomic Clusters as State Markers of Major Depression and Outcomes to CBT Treatment" @default.
- W2969771230 cites W170316455 @default.
- W2969771230 cites W1966327575 @default.
- W2969771230 cites W1968486566 @default.
- W2969771230 cites W1975778730 @default.
- W2969771230 cites W1990246481 @default.
- W2969771230 cites W1993701317 @default.
- W2969771230 cites W1999601412 @default.
- W2969771230 cites W2004452745 @default.
- W2969771230 cites W2011073040 @default.
- W2969771230 cites W202043522 @default.
- W2969771230 cites W2022494361 @default.
- W2969771230 cites W2031227896 @default.
- W2969771230 cites W2037136746 @default.
- W2969771230 cites W2061378977 @default.
- W2969771230 cites W2084415324 @default.
- W2969771230 cites W2085644757 @default.
- W2969771230 cites W2123830992 @default.
- W2969771230 cites W2140592967 @default.
- W2969771230 cites W2467710961 @default.
- W2969771230 cites W2499242815 @default.
- W2969771230 cites W2522599389 @default.
- W2969771230 cites W2591157058 @default.
- W2969771230 cites W2600118519 @default.
- W2969771230 cites W2601834048 @default.
- W2969771230 cites W2611710834 @default.
- W2969771230 cites W2791961206 @default.
- W2969771230 cites W2804813128 @default.
- W2969771230 cites W2807457056 @default.
- W2969771230 cites W2812177042 @default.
- W2969771230 cites W2885260563 @default.
- W2969771230 cites W2889306102 @default.
- W2969771230 cites W2899816509 @default.
- W2969771230 cites W2912102328 @default.
- W2969771230 cites W2919454412 @default.
- W2969771230 cites W2955026049 @default.
- W2969771230 doi "https://doi.org/10.3389/fnins.2019.00926" @default.
- W2969771230 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6751322" @default.
- W2969771230 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31572108" @default.
- W2969771230 hasPublicationYear "2019" @default.
- W2969771230 type Work @default.
- W2969771230 sameAs 2969771230 @default.
- W2969771230 citedByCount "13" @default.
- W2969771230 countsByYear W29697712302020 @default.
- W2969771230 countsByYear W29697712302021 @default.
- W2969771230 countsByYear W29697712302022 @default.
- W2969771230 countsByYear W29697712302023 @default.
- W2969771230 crossrefType "journal-article" @default.
- W2969771230 hasAuthorship W2969771230A5005712710 @default.
- W2969771230 hasAuthorship W2969771230A5015972818 @default.
- W2969771230 hasAuthorship W2969771230A5022104848 @default.
- W2969771230 hasAuthorship W2969771230A5025091889 @default.
- W2969771230 hasAuthorship W2969771230A5026199142 @default.
- W2969771230 hasAuthorship W2969771230A5029433360 @default.
- W2969771230 hasAuthorship W2969771230A5056312367 @default.
- W2969771230 hasAuthorship W2969771230A5056637382 @default.
- W2969771230 hasAuthorship W2969771230A5061744695 @default.
- W2969771230 hasAuthorship W2969771230A5072914653 @default.
- W2969771230 hasAuthorship W2969771230A5078348766 @default.
- W2969771230 hasAuthorship W2969771230A5090955632 @default.
- W2969771230 hasBestOaLocation W29697712301 @default.
- W2969771230 hasConcept C118552586 @default.
- W2969771230 hasConcept C126322002 @default.
- W2969771230 hasConcept C139719470 @default.
- W2969771230 hasConcept C15744967 @default.
- W2969771230 hasConcept C162324750 @default.
- W2969771230 hasConcept C169900460 @default.
- W2969771230 hasConcept C21565614 @default.
- W2969771230 hasConcept C2776867660 @default.
- W2969771230 hasConcept C2780051608 @default.
- W2969771230 hasConcept C60644358 @default.
- W2969771230 hasConcept C70410870 @default.
- W2969771230 hasConcept C71924100 @default.
- W2969771230 hasConcept C86803240 @default.
- W2969771230 hasConceptScore W2969771230C118552586 @default.
- W2969771230 hasConceptScore W2969771230C126322002 @default.
- W2969771230 hasConceptScore W2969771230C139719470 @default.
- W2969771230 hasConceptScore W2969771230C15744967 @default.
- W2969771230 hasConceptScore W2969771230C162324750 @default.
- W2969771230 hasConceptScore W2969771230C169900460 @default.
- W2969771230 hasConceptScore W2969771230C21565614 @default.
- W2969771230 hasConceptScore W2969771230C2776867660 @default.
- W2969771230 hasConceptScore W2969771230C2780051608 @default.
- W2969771230 hasConceptScore W2969771230C60644358 @default.