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- W2969771306 abstract "Abstract Gastrointestinal symptoms appear in Parkinson's disease patients many years before motor symptoms, suggesting the implication of dopaminergic neurones of the gut myenteric plexus. Inflammation is also known to be increased in PD . We previously reported neuroprotection with progesterone in the brain of mice lesioned with 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine ( MPTP ) and hypothesised that it also has neuroprotective and immunomodulatory activities in the gut. To test this hypothesis, we investigated progesterone administered to adult male C57 BL /6 mice for 10 days and treated with MPTP on day 5. In an additional experiment, progesterone was administered for 5 days following MPTP treatment. Ilea were collected on day 10 of treatment and microdissected to isolate the myenteric plexus. Dopaminergic neurones were reduced by approximately 60% and pro‐inflammatory macrophages were increased by approximately 50% in MPTP mice compared to intact controls. These changes were completely prevented by progesterone administered before and after MPTP treatment and were normalised by 8 mg kg ‐1 progesterone administered after MPTP . In the brain of MPTP mice, brain‐derived neurotrophic peptide ( BDNF ) and glial fibrillary acidic protein ( GFAP ) were associated with progesterone neuroprotection. In the myenteric plexus, increased BDNF levels compared to controls were measured in MPTP mice treated with 8 mg kg ‐1 progesterone started post MPTP , whereas GFAP levels remained unchanged. In conclusion, the results obtained in the present study show neuroprotective and anti‐inflammatory effects of progesterone in the myenteric plexus of MPTP mice that are similar to our previous findings in the brain. Progesterone is non‐feminising and could be used for both men and women in the pre‐symptomatic stages of the disease." @default.
- W2969771306 created "2019-08-29" @default.
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- W2969771306 date "2019-09-10" @default.
- W2969771306 modified "2023-09-27" @default.
- W2969771306 title "Neuroprotection and immunomodulation of progesterone in the gut of a mouse model of Parkinson's disease" @default.
- W2969771306 cites W1045284996 @default.
- W2969771306 cites W1503382483 @default.
- W2969771306 cites W1532405140 @default.
- W2969771306 cites W1568656531 @default.
- W2969771306 cites W1807343300 @default.
- W2969771306 cites W1973986558 @default.
- W2969771306 cites W1975259854 @default.
- W2969771306 cites W1975941800 @default.
- W2969771306 cites W1979237351 @default.
- W2969771306 cites W1981216611 @default.
- W2969771306 cites W1984692888 @default.
- W2969771306 cites W1989990363 @default.
- W2969771306 cites W1991321319 @default.
- W2969771306 cites W1992545248 @default.
- W2969771306 cites W1993241967 @default.
- W2969771306 cites W1994967294 @default.
- W2969771306 cites W1995281235 @default.
- W2969771306 cites W1997562103 @default.
- W2969771306 cites W1998101301 @default.
- W2969771306 cites W1998104342 @default.
- W2969771306 cites W2005907346 @default.
- W2969771306 cites W2010619614 @default.
- W2969771306 cites W2012611698 @default.
- W2969771306 cites W2016179616 @default.
- W2969771306 cites W2019010892 @default.
- W2969771306 cites W2022077813 @default.
- W2969771306 cites W2027548273 @default.
- W2969771306 cites W2029879331 @default.
- W2969771306 cites W2030637641 @default.
- W2969771306 cites W2031740174 @default.
- W2969771306 cites W2035533851 @default.
- W2969771306 cites W2037486805 @default.
- W2969771306 cites W2039064011 @default.
- W2969771306 cites W2046730725 @default.
- W2969771306 cites W2046885195 @default.
- W2969771306 cites W2046960535 @default.
- W2969771306 cites W2053943396 @default.
- W2969771306 cites W2059752869 @default.
- W2969771306 cites W2060782496 @default.
- W2969771306 cites W2063229033 @default.
- W2969771306 cites W2065518048 @default.
- W2969771306 cites W2068120156 @default.
- W2969771306 cites W2070156806 @default.
- W2969771306 cites W2072974386 @default.
- W2969771306 cites W2076087096 @default.
- W2969771306 cites W2080778120 @default.
- W2969771306 cites W2084357246 @default.
- W2969771306 cites W2086816316 @default.
- W2969771306 cites W2087751760 @default.
- W2969771306 cites W2087848764 @default.
- W2969771306 cites W2091810228 @default.
- W2969771306 cites W2096502206 @default.
- W2969771306 cites W2100123567 @default.
- W2969771306 cites W2106644699 @default.
- W2969771306 cites W2113179569 @default.
- W2969771306 cites W2117645041 @default.
- W2969771306 cites W2119948313 @default.
- W2969771306 cites W2140038023 @default.
- W2969771306 cites W2142483035 @default.
- W2969771306 cites W2149602538 @default.
- W2969771306 cites W2165976376 @default.
- W2969771306 cites W2220420147 @default.
- W2969771306 cites W2330739939 @default.
- W2969771306 cites W2509742087 @default.
- W2969771306 cites W2586901051 @default.
- W2969771306 cites W2664285244 @default.
- W2969771306 cites W2771347580 @default.
- W2969771306 cites W2797336411 @default.
- W2969771306 cites W2903980241 @default.
- W2969771306 cites W2909041556 @default.
- W2969771306 cites W2909409818 @default.
- W2969771306 cites W2909716959 @default.
- W2969771306 cites W4313376320 @default.
- W2969771306 cites W634330581 @default.
- W2969771306 doi "https://doi.org/10.1111/jne.12782" @default.
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- W2969771306 hasPublicationYear "2019" @default.
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