FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2969773393> ?p ?o ?g. }

• W2969773393 endingPage "1225" @default.
• W2969773393 startingPage "1225" @default.
• W2969773393 abstract "Background: In human populations, a certain amount of data correlate obesity/body mass index (BMI) with urothelial cancer (UC) and prostate cancer (PCa) occurrence, however this is not fully elucidated at all stages of disease. In an attempt to shed light on uncertain areas in such field, in the present review we illustrate the main molecular mechanisms linking obesity and cancer, focusing on the correlation between obesity and tumor risk, disease progression and response to chemo- and immunotherapy in patients with UC and the predictive/prognostic role of obesity in PCa patients treated with the currently available therapeutic approaches. Methods: We did a large-scale literature search on existing scientific websites focusing on keywords “obesity”, “body mass index (BMI)”, “urothelial cancer”, “prostate cancer”, “docetaxel”, “cabazitaxel”, “abiraterone acetate”, “enzalutamide”, and “radium223”. Results: Many adipocytes-induced molecules support tumor proliferation through activation of various cellular pathways. The available evidence in the postoperative setting do the role of BMI in oncological outcomes prediction still not completely clear. Likewise, in metastatic UC patients controversial results link the role of obesity/BMI with clinical outcomes of tumor response to chemotherapy. Adipose stromal cells recruitment, induced by PCa cells, from white adipose tissue to the tumor sites inducing cell invasiveness was associated with poor survival. Conflicting data, although more oriented towards a better survival outcome, resulted in obese patients treated with docetaxel. In PCa cell-lines a certain cabazitaxel chemo resistance adipose stromal cells (ASC)-mediated was demonstrated. In metastatic castration-resistant PCa patients with high BMI (>25 kg/m2) receiving abiraterone acetate there were significant worse survival outcomes, while in enzalutamide patients BMI did not affect survival outcome. In radium 223 patients higher BMI significantly correlated with favorable overall survival. Conclusions: The main focus of this review was to understand the interplay between obesity/BMI and UC/PCa. Several pathogenic cellular pathways exploring the issue are discussed, opening the way to challenging tailored treatments on the basis of BMI. Improving the knowledge of molecular connections between obesity and UC and PCa could favor the development of new therapies likely reducing chemo- and immunotherapy drug resistance." @default.
• W2969773393 created "2019-08-29" @default.
• W2969773393 creator A5000699628 @default.
• W2969773393 creator A5021477463 @default.
• W2969773393 creator A5028046234 @default.
• W2969773393 creator A5030533194 @default.
• W2969773393 creator A5040616139 @default.
• W2969773393 creator A5048165263 @default.
• W2969773393 creator A5054063272 @default.
• W2969773393 creator A5058161742 @default.
• W2969773393 creator A5063109707 @default.
• W2969773393 creator A5063795761 @default.
• W2969773393 creator A5064083940 @default.
• W2969773393 creator A5069993810 @default.
• W2969773393 creator A5091054206 @default.
• W2969773393 date "2019-08-22" @default.
• W2969773393 modified "2023-09-28" @default.
• W2969773393 title "Key Role of Obesity in Genitourinary Tumors with Emphasis on Urothelial and Prostate Cancers" @default.
• W2969773393 cites W1177269388 @default.
• W2969773393 cites W1520254879 @default.
• W2969773393 cites W1524872430 @default.
• W2969773393 cites W1605989672 @default.
• W2969773393 cites W1689834394 @default.
• W2969773393 cites W1754760787 @default.
• W2969773393 cites W1762202522 @default.
• W2969773393 cites W1778688357 @default.
• W2969773393 cites W1964631256 @default.
• W2969773393 cites W1966672503 @default.
• W2969773393 cites W1986234170 @default.
• W2969773393 cites W1988307337 @default.
• W2969773393 cites W1995821091 @default.
• W2969773393 cites W1997459531 @default.
• W2969773393 cites W1997533465 @default.
• W2969773393 cites W2009997802 @default.
• W2969773393 cites W2011957420 @default.
• W2969773393 cites W2012295573 @default.
• W2969773393 cites W2012395662 @default.
• W2969773393 cites W2020667072 @default.
• W2969773393 cites W2023881466 @default.
• W2969773393 cites W2026381062 @default.
• W2969773393 cites W2049140983 @default.
• W2969773393 cites W2056040807 @default.
• W2969773393 cites W2062334173 @default.
• W2969773393 cites W2065404455 @default.
• W2969773393 cites W2093970255 @default.
• W2969773393 cites W2103043554 @default.
• W2969773393 cites W2103257412 @default.
• W2969773393 cites W2114532259 @default.
• W2969773393 cites W2120292596 @default.
• W2969773393 cites W2120854891 @default.
• W2969773393 cites W2120955645 @default.
• W2969773393 cites W2125041563 @default.
• W2969773393 cites W2131713301 @default.
• W2969773393 cites W2135144012 @default.
• W2969773393 cites W2140758137 @default.
• W2969773393 cites W2141662760 @default.
• W2969773393 cites W2142655750 @default.
• W2969773393 cites W2143814249 @default.
• W2969773393 cites W2147180151 @default.
• W2969773393 cites W2148562299 @default.
• W2969773393 cites W2148643283 @default.
• W2969773393 cites W2151028908 @default.
• W2969773393 cites W2151720799 @default.
• W2969773393 cites W2152913697 @default.
• W2969773393 cites W2153383900 @default.
• W2969773393 cites W2154029052 @default.
• W2969773393 cites W2165753321 @default.
• W2969773393 cites W2167771818 @default.
• W2969773393 cites W2168108459 @default.
• W2969773393 cites W2168972202 @default.
• W2969773393 cites W2196142402 @default.
• W2969773393 cites W2212015457 @default.
• W2969773393 cites W2223535266 @default.
• W2969773393 cites W2235523093 @default.
• W2969773393 cites W2261997507 @default.
• W2969773393 cites W2279601410 @default.
• W2969773393 cites W2280073344 @default.
• W2969773393 cites W2282143561 @default.
• W2969773393 cites W2295358293 @default.
• W2969773393 cites W2302564246 @default.
• W2969773393 cites W2308722283 @default.
• W2969773393 cites W2324559253 @default.
• W2969773393 cites W2332342311 @default.
• W2969773393 cites W2347023427 @default.
• W2969773393 cites W2350719384 @default.
• W2969773393 cites W2372621804 @default.
• W2969773393 cites W2397377428 @default.
• W2969773393 cites W2401033555 @default.
• W2969773393 cites W2415649514 @default.
• W2969773393 cites W2556968169 @default.
• W2969773393 cites W2567264284 @default.
• W2969773393 cites W2588916311 @default.
• W2969773393 cites W2602651379 @default.
• W2969773393 cites W2763611493 @default.
• W2969773393 cites W2766372364 @default.
• W2969773393 cites W2767034326 @default.
• W2969773393 cites W2775971156 @default.
• W2969773393 cites W2777192533 @default.

• next