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- W2969773654 endingPage "984" @default.
- W2969773654 startingPage "973" @default.
- W2969773654 abstract "The aim of this study was to evaluate outcomes of patients with resectable pancreatic adenocarcinoma (PDAC) who underwent neoadjuvant chemotherapy. The MEDLINE and PubMed databases were searched to identify relevant original articles investigating neoadjuvant therapy in resectable PDAC. Qualitative analyses were performed to investigate patient selection, disease stage, impact on perioperative outcomes, and cost-effectiveness. Forty-three studies met inclusion criteria for this review. Neoadjuvant chemotherapy for upfront resectable PDAC is cost-effective, safe, may result in lower stage disease and has potential survival advantages. With proper patient selection, neoadjuvant chemotherapy is an appropriate approach for upfront resectable PDAC. Nevertheless, the risk for disease progression and losing a curative surgical window highlights the need for appropriate patient identification, further discovery of superior biomarkers or molecular profiles representative of positive treatment response, and additional prospective comparative study." @default.
- W2969773654 created "2019-08-29" @default.
- W2969773654 creator A5039843730 @default.
- W2969773654 creator A5062669403 @default.
- W2969773654 creator A5070188771 @default.
- W2969773654 creator A5070343470 @default.
- W2969773654 date "2019-09-01" @default.
- W2969773654 modified "2023-09-26" @default.
- W2969773654 title "A Qualitative Review of Neoadjuvant Chemotherapy in Resectable Pancreatic Adenocarcinoma" @default.
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- W2969773654 doi "https://doi.org/10.1097/mpa.0000000000001376" @default.
- W2969773654 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31425483" @default.
- W2969773654 hasPublicationYear "2019" @default.
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