Matches in SemOpenAlex for { <https://semopenalex.org/work/W2969777750> ?p ?o ?g. }
- W2969777750 abstract "Abstract While considerable progress has been made in studying genetic and cellular aspects of metastasis with in vitro cell culture and in vivo animal models, the driving mechanisms of each step of metastasis are still relatively unclear due to their complexity. Moreover, little progress has been made in understanding how cellular fitness in one step of the metastatic cascade correlates with ability to survive other subsequent steps. Engineered models incorporate tools such as tailored biomaterials and microfabrication to mimic human disease progression, which when coupled with advanced quantification methods permit comparisons to human patient samples and in vivo studies. Here, we review novel tools and techniques that have been recently developed to dissect key features of the metastatic cascade using primary patient samples and highly representative microenvironments for the purposes of advancing personalized medicine and precision oncology. Although improvements are needed to increase tractability and accessibility while faithfully simulating the in vivo microenvironment, these models are powerful experimental platforms for understanding cancer biology, furthering drug screening, and facilitating development of therapeutics." @default.
- W2969777750 created "2019-08-29" @default.
- W2969777750 creator A5035287010 @default.
- W2969777750 creator A5050011168 @default.
- W2969777750 creator A5053112617 @default.
- W2969777750 creator A5068148615 @default.
- W2969777750 date "2019-08-21" @default.
- W2969777750 modified "2023-10-16" @default.
- W2969777750 title "Engineered models to parse apart the metastatic cascade" @default.
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