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• W2969784743 endingPage "303" @default.
• W2969784743 startingPage "231" @default.
• W2969784743 abstract "The passage of time dictates the pace at which humans and other organisms age but falls short of providing a complete portrait of how environmental, lifestyle and underlying biological processes contribute to senescence. Two fundamental features of the human experience that change dramatically across the lifespan include social interactions and, for many, patterns of alcohol consumption. Rodent models show great utility for understanding complex interactions among aging, social behavior and alcohol use and abuse, yet little is known about the neural changes in late aging that contribute to the natural decline in social behavior. Here, we posit that aging-related neuroinflammation contributes to the insipid loss of social motivation across the lifespan, an effect that is exacerbated by patterns of repeated alcohol consumption observed in many individuals. We provide a comprehensive review of (i) neural substrates crucial for the expression of social behavior under non-pathological conditions; (ii) unique developmental/lifespan vulnerabilities that may contribute to the divergent effects of low-and high-dose alcohol exposure; and (iii) aging-associated changes in neuroinflammation that may sit at the intersection between social processes and alcohol exposure. In doing so, we provide an overview of correspondence between lifespan/developmental periods between common rodent models and humans, give careful consideration to model systems used to aptly probe social behavior, identify points of coherence between human and animal models, and point toward a multitude of unresolved issues that should be addressed in future studies. Together, the combination of low-dose and high-dose alcohol effects serve to disrupt the normal development and maintenance of social relationships, which are critical for both healthy aging and quality of life across the lifespan. Thus, a more complete understanding of neural systems—including neuroinflammatory processes—which contribute to alcohol-induced changes in social behavior will provide novel opportunities and targets for promoting healthy aging." @default.
• W2969784743 created "2019-08-29" @default.
• W2969784743 creator A5027822888 @default.
• W2969784743 creator A5060295416 @default.
• W2969784743 creator A5078833825 @default.
• W2969784743 date "2019-01-01" @default.
• W2969784743 modified "2023-09-30" @default.
• W2969784743 title "From adolescence to late aging: A comprehensive review of social behavior, alcohol, and neuroinflammation across the lifespan" @default.
• W2969784743 cites W1015756911 @default.
• W2969784743 cites W1172796801 @default.
• W2969784743 cites W1271611779 @default.
• W2969784743 cites W1468286270 @default.
• W2969784743 cites W1541159186 @default.
• W2969784743 cites W1544936282 @default.
• W2969784743 cites W1577588217 @default.
• W2969784743 cites W1622777525 @default.
• W2969784743 cites W1689813214 @default.
• W2969784743 cites W1737110258 @default.
• W2969784743 cites W1812455716 @default.
• W2969784743 cites W1879524055 @default.
• W2969784743 cites W1895522105 @default.
• W2969784743 cites W1901457319 @default.
• W2969784743 cites W1919476441 @default.
• W2969784743 cites W1944901559 @default.
• W2969784743 cites W1963498266 @default.
• W2969784743 cites W1963589197 @default.
• W2969784743 cites W1963646496 @default.
• W2969784743 cites W1964106826 @default.
• W2969784743 cites W1965959004 @default.
• W2969784743 cites W1966445523 @default.
• W2969784743 cites W1967487244 @default.
• W2969784743 cites W1967642285 @default.
• W2969784743 cites W1967727674 @default.
• W2969784743 cites W1968712199 @default.
• W2969784743 cites W1969162136 @default.
• W2969784743 cites W1969938006 @default.
• W2969784743 cites W1970128583 @default.
• W2969784743 cites W1970134980 @default.
• W2969784743 cites W1970734866 @default.
• W2969784743 cites W1970790819 @default.
• W2969784743 cites W1970972216 @default.
• W2969784743 cites W1971328065 @default.
• W2969784743 cites W1972563980 @default.
• W2969784743 cites W1973838846 @default.
• W2969784743 cites W1973842330 @default.
• W2969784743 cites W1975931952 @default.
• W2969784743 cites W1977125554 @default.
• W2969784743 cites W1978307290 @default.
• W2969784743 cites W1978497905 @default.
• W2969784743 cites W1980153370 @default.
• W2969784743 cites W1980926695 @default.
• W2969784743 cites W1981993772 @default.
• W2969784743 cites W1982540819 @default.
• W2969784743 cites W1982754908 @default.
• W2969784743 cites W1983752276 @default.
• W2969784743 cites W1985472728 @default.
• W2969784743 cites W1985645068 @default.
• W2969784743 cites W1985661446 @default.
• W2969784743 cites W1986071541 @default.
• W2969784743 cites W1986079135 @default.
• W2969784743 cites W1986717462 @default.
• W2969784743 cites W1987037769 @default.
• W2969784743 cites W1987742395 @default.
• W2969784743 cites W1988072470 @default.
• W2969784743 cites W1989815188 @default.
• W2969784743 cites W1990005991 @default.
• W2969784743 cites W1990256337 @default.
• W2969784743 cites W1990445317 @default.
• W2969784743 cites W1991045006 @default.
• W2969784743 cites W1991515600 @default.
• W2969784743 cites W1991805788 @default.
• W2969784743 cites W1992256029 @default.
• W2969784743 cites W1992920498 @default.
• W2969784743 cites W1993142638 @default.
• W2969784743 cites W1993258961 @default.
• W2969784743 cites W1994574623 @default.
• W2969784743 cites W1994873680 @default.
• W2969784743 cites W1995122859 @default.
• W2969784743 cites W1995744610 @default.
• W2969784743 cites W1996331934 @default.
• W2969784743 cites W1997032097 @default.
• W2969784743 cites W1997385502 @default.
• W2969784743 cites W1997696271 @default.
• W2969784743 cites W1997723786 @default.
• W2969784743 cites W1998195441 @default.
• W2969784743 cites W1998499579 @default.
• W2969784743 cites W2000405843 @default.
• W2969784743 cites W2000653311 @default.
• W2969784743 cites W2001212858 @default.
• W2969784743 cites W2001635982 @default.
• W2969784743 cites W2004913561 @default.
• W2969784743 cites W2006018417 @default.
• W2969784743 cites W2006218483 @default.
• W2969784743 cites W2007133544 @default.
• W2969784743 cites W2007630334 @default.
• W2969784743 cites W2007642452 @default.
• W2969784743 cites W2008239841 @default.
• W2969784743 cites W2008312242 @default.

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