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- W2969795423 abstract "The female sex hormone 17beta-estradiol, produced naturally in the body, seems to play an important role in the development of breast cancer, since (i) it can be activated to reactive metabolites, which are known to damage DNA and (ii) the stimulation of the estrogen receptor alpha by 17beta-estradiol enhances cell proliferation. Both processes together increase mutation frequency and subsequently lead to transformation of epithelial cells. Therefore, the aim of this work was to characterize the influence of polymorphisms and lifestyle factors on 17beta-estradiol metabolism in normal mammary gland tissue. [...] In sum, the tissue specific 17beta-estradiol metabolism was described in mammary gland tissue homogenate, whereas differences in proliferation of epithelial cells were only reflected in isolated epithelial cells. Factors associated with breast cancer risk (age, BMI and age-related changes in mammary gland morphology) were shown to affect 17beta-estradiol tissue levels.The 17beta-estradiol mediated genotoxicity was evaluated using bioinformatically calculatedDNA adduct fluxes, which were predominately influenced by individual mRNA patterns rather than individual genotypes and (DNA adduct fluxes) were correlated with known breast cancer risk factors (age, parity, BMI and polymorphism of glutathione-S-transferase theta 1)." @default.
- W2969795423 created "2019-08-29" @default.
- W2969795423 creator A5025592969 @default.
- W2969795423 date "2014-01-01" @default.
- W2969795423 modified "2023-09-23" @default.
- W2969795423 title "Identification of factors influencing 17beta-estradiol metabolism in female mammary gland" @default.
- W2969795423 hasPublicationYear "2014" @default.
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