FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2969798465> ?p ?o ?g. }

• W2969798465 endingPage "271" @default.
• W2969798465 startingPage "256" @default.
• W2969798465 abstract "Interstitial lung diseases encompass a large number of entities, which are characterised by a small number of partially overlapping fibrosing injury patterns, either alone or in combination. Thus, the presently applied morphological diagnostic criteria do not reliably discriminate different interstitial lung diseases. We therefore analysed critical regulatory pathways and signalling molecules involved in pulmonary remodelling with regard to their diagnostic suitability. Using laser-microdissection and microarray techniques, we examined the expression patterns of 45 tissue-remodelling associated target genes in remodelled and non-remodelled tissue samples from patients with idiopathic pulmonary fibrosis/usual interstitial pneumonia (IPF/UIP), non-specific interstitial pneumonia (NSIP), organising pneumonia (OP) and alveolar fibroelastosis (AFE), as well as controls (81 patients in total). We found a shared usage of pivotal pathways in AFE, NSIP, OP and UIP, but also individual molecular traits, which set the fibrosing injury patterns apart from each other and correlate well with their specific morphological aspects. Comparison of the aberrant gene expression patterns demonstrated that (1) molecular profiling in fibrosing lung diseases is feasible, (2) pulmonary injury patterns can be discriminated with very high confidence on a molecular level (86-100% specificity) using individual gene subsets and (3) these findings can be adapted as suitable diagnostic adjuncts." @default.
• W2969798465 created "2019-08-29" @default.
• W2969798465 creator A5001013964 @default.
• W2969798465 creator A5001538826 @default.
• W2969798465 creator A5002591562 @default.
• W2969798465 creator A5014648398 @default.
• W2969798465 creator A5015246499 @default.
• W2969798465 creator A5032243798 @default.
• W2969798465 creator A5042536098 @default.
• W2969798465 creator A5063911134 @default.
• W2969798465 creator A5068639127 @default.
• W2969798465 creator A5075687869 @default.
• W2969798465 creator A5084519339 @default.
• W2969798465 creator A5086531770 @default.
• W2969798465 date "2019-09-25" @default.
• W2969798465 modified "2023-10-18" @default.
• W2969798465 title "Morphological and molecular motifs of fibrosing pulmonary injury patterns" @default.
• W2969798465 cites W10297047 @default.
• W2969798465 cites W1499343810 @default.
• W2969798465 cites W1539840949 @default.
• W2969798465 cites W1585826760 @default.
• W2969798465 cites W1676246072 @default.
• W2969798465 cites W1782928917 @default.
• W2969798465 cites W1965951565 @default.
• W2969798465 cites W1966085047 @default.
• W2969798465 cites W1972945811 @default.
• W2969798465 cites W1979720913 @default.
• W2969798465 cites W1996730427 @default.
• W2969798465 cites W2005361097 @default.
• W2969798465 cites W2018078168 @default.
• W2969798465 cites W2020830188 @default.
• W2969798465 cites W2027756860 @default.
• W2969798465 cites W2031322849 @default.
• W2969798465 cites W2039831661 @default.
• W2969798465 cites W2040847714 @default.
• W2969798465 cites W2042823774 @default.
• W2969798465 cites W2043915302 @default.
• W2969798465 cites W2048268549 @default.
• W2969798465 cites W2052572787 @default.
• W2969798465 cites W2058540485 @default.
• W2969798465 cites W2060469376 @default.
• W2969798465 cites W2070494689 @default.
• W2969798465 cites W2082406727 @default.
• W2969798465 cites W2083916238 @default.
• W2969798465 cites W2097202285 @default.
• W2969798465 cites W2099754347 @default.
• W2969798465 cites W2100636073 @default.
• W2969798465 cites W2104766198 @default.
• W2969798465 cites W2105325938 @default.
• W2969798465 cites W2106785460 @default.
• W2969798465 cites W2110499503 @default.
• W2969798465 cites W2115223685 @default.
• W2969798465 cites W2120257670 @default.
• W2969798465 cites W2132189654 @default.
• W2969798465 cites W2138871107 @default.
• W2969798465 cites W2146484111 @default.
• W2969798465 cites W2149603299 @default.
• W2969798465 cites W2149661971 @default.
• W2969798465 cites W2162143298 @default.
• W2969798465 cites W2162175607 @default.
• W2969798465 cites W2167383172 @default.
• W2969798465 cites W2210358786 @default.
• W2969798465 cites W2292742428 @default.
• W2969798465 cites W2328063233 @default.
• W2969798465 cites W2410932134 @default.
• W2969798465 cites W2415593903 @default.
• W2969798465 cites W2441531852 @default.
• W2969798465 cites W2464664289 @default.
• W2969798465 cites W2466920981 @default.
• W2969798465 cites W2511032361 @default.
• W2969798465 cites W2519504222 @default.
• W2969798465 cites W2528726906 @default.
• W2969798465 cites W2726475926 @default.
• W2969798465 cites W2750618880 @default.
• W2969798465 cites W2757116276 @default.
• W2969798465 cites W2779515182 @default.
• W2969798465 cites W2784738994 @default.
• W2969798465 cites W2798081375 @default.
• W2969798465 cites W2799479598 @default.
• W2969798465 cites W2806460375 @default.
• W2969798465 cites W2889197569 @default.
• W2969798465 cites W2901766248 @default.
• W2969798465 cites W2930468941 @default.
• W2969798465 cites W3025576394 @default.
• W2969798465 cites W2408684221 @default.
• W2969798465 doi "https://doi.org/10.1002/cjp2.141" @default.
• W2969798465 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6817833" @default.
• W2969798465 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31433553" @default.
• W2969798465 hasPublicationYear "2019" @default.
• W2969798465 type Work @default.
• W2969798465 sameAs 2969798465 @default.
• W2969798465 citedByCount "13" @default.
• W2969798465 countsByYear W29697984652019 @default.
• W2969798465 countsByYear W29697984652020 @default.
• W2969798465 countsByYear W29697984652021 @default.
• W2969798465 countsByYear W29697984652022 @default.
• W2969798465 countsByYear W29697984652023 @default.
• W2969798465 crossrefType "journal-article" @default.

• next