Matches in SemOpenAlex for { <https://semopenalex.org/work/W2969802238> ?p ?o ?g. }
- W2969802238 endingPage "978" @default.
- W2969802238 startingPage "978" @default.
- W2969802238 abstract "Among the non-human primates used in experimental medicine, cynomolgus macaques (Macaca fascicularis hereafter referred to as Mafa) are increasingly selected for the ease with which they are maintained and bred in captivity. Macaques belong to Old World monkeys and are phylogenetically much closer to humans than rodents, which are still the most frequently used animal model. Our understanding of the Mafa genome has progressed rapidly in recent years and has greatly benefited from the latest technical advances in molecular genetics. Cynomolgus macaques are widespread in Southeast Asia and numerous studies have shown a distinct genetic differentiation of continental and island populations. The major histocompatibility complex of cynomolgus macaque (Mafa MHC) is organized in the same way as that of human, but it differs from the latter by its high degree of classical class I gene duplication. Human polymorphic MHC regions play a pivotal role in allograft transplantation and have been associated with more than 100 diseases and/or phenotypes. The Mafa MHC polymorphism similarly plays a crucial role in experimental allografts of organs and stem cells. Experimental results show that the Mafa MHC class I and II regions influence the ability to mount an immune response against infectious pathogens and vaccines. MHC also affects cynomolgus macaque reproduction and impacts on numerous biological parameters. This review describes the Mafa MHC polymorphism and the methods currently used to characterize it. We discuss some of the major areas of experimental medicine where an effect induced by MHC polymorphism has been demonstrated." @default.
- W2969802238 created "2019-08-29" @default.
- W2969802238 creator A5065226364 @default.
- W2969802238 creator A5072324110 @default.
- W2969802238 date "2019-08-26" @default.
- W2969802238 modified "2023-10-10" @default.
- W2969802238 title "The Cynomolgus Macaque MHC Polymorphism in Experimental Medicine" @default.
- W2969802238 cites W1490736032 @default.
- W2969802238 cites W1496318629 @default.
- W2969802238 cites W1513401272 @default.
- W2969802238 cites W1532781251 @default.
- W2969802238 cites W1549389235 @default.
- W2969802238 cites W1570463153 @default.
- W2969802238 cites W1590297216 @default.
- W2969802238 cites W1677578131 @default.
- W2969802238 cites W1811127912 @default.
- W2969802238 cites W1877153573 @default.
- W2969802238 cites W1902800866 @default.
- W2969802238 cites W1906987668 @default.
- W2969802238 cites W1927791357 @default.
- W2969802238 cites W1939367053 @default.
- W2969802238 cites W1942000333 @default.
- W2969802238 cites W1964653209 @default.
- W2969802238 cites W1967795727 @default.
- W2969802238 cites W1968201761 @default.
- W2969802238 cites W1971990483 @default.
- W2969802238 cites W1972109648 @default.
- W2969802238 cites W1973943793 @default.
- W2969802238 cites W1974616223 @default.
- W2969802238 cites W1975088252 @default.
- W2969802238 cites W1975563165 @default.
- W2969802238 cites W1979134719 @default.
- W2969802238 cites W1979362833 @default.
- W2969802238 cites W1980843873 @default.
- W2969802238 cites W1981470925 @default.
- W2969802238 cites W1985291649 @default.
- W2969802238 cites W1985490901 @default.
- W2969802238 cites W1987045065 @default.
- W2969802238 cites W1988749876 @default.
- W2969802238 cites W1989166597 @default.
- W2969802238 cites W1990462828 @default.
- W2969802238 cites W1991447717 @default.
- W2969802238 cites W1991822609 @default.
- W2969802238 cites W1993427364 @default.
- W2969802238 cites W1994147316 @default.
- W2969802238 cites W1996502147 @default.
- W2969802238 cites W1997127958 @default.
- W2969802238 cites W1997507707 @default.
- W2969802238 cites W1998666190 @default.
- W2969802238 cites W1998681478 @default.
- W2969802238 cites W2000866453 @default.
- W2969802238 cites W2002972775 @default.
- W2969802238 cites W2003365769 @default.
- W2969802238 cites W2005670070 @default.
- W2969802238 cites W2007564627 @default.
- W2969802238 cites W2009273285 @default.
- W2969802238 cites W2012500528 @default.
- W2969802238 cites W2013435992 @default.
- W2969802238 cites W2014208459 @default.
- W2969802238 cites W2015863483 @default.
- W2969802238 cites W2016526297 @default.
- W2969802238 cites W2018335747 @default.
- W2969802238 cites W2018897975 @default.
- W2969802238 cites W2019409153 @default.
- W2969802238 cites W2019435428 @default.
- W2969802238 cites W2021934926 @default.
- W2969802238 cites W2022014947 @default.
- W2969802238 cites W2022380015 @default.
- W2969802238 cites W2023345194 @default.
- W2969802238 cites W2023646993 @default.
- W2969802238 cites W2025859070 @default.
- W2969802238 cites W2025865280 @default.
- W2969802238 cites W2026498036 @default.
- W2969802238 cites W2028518212 @default.
- W2969802238 cites W2032311493 @default.
- W2969802238 cites W2032621251 @default.
- W2969802238 cites W2038483313 @default.
- W2969802238 cites W2039237849 @default.
- W2969802238 cites W2042442061 @default.
- W2969802238 cites W2045467930 @default.
- W2969802238 cites W2046143234 @default.
- W2969802238 cites W2046456510 @default.
- W2969802238 cites W2049584295 @default.
- W2969802238 cites W2054641125 @default.
- W2969802238 cites W2059877230 @default.
- W2969802238 cites W2062204620 @default.
- W2969802238 cites W2065868529 @default.
- W2969802238 cites W2067177161 @default.
- W2969802238 cites W2069640034 @default.
- W2969802238 cites W2069926681 @default.
- W2969802238 cites W2071967924 @default.
- W2969802238 cites W2072277150 @default.
- W2969802238 cites W2073368717 @default.
- W2969802238 cites W2075647477 @default.
- W2969802238 cites W2076293195 @default.
- W2969802238 cites W2076542934 @default.
- W2969802238 cites W2076964460 @default.
- W2969802238 cites W2077116679 @default.