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• W2969814123 endingPage "100766" @default.
• W2969814123 startingPage "100766" @default.
• W2969814123 abstract "In the early nineties, pioneering steps were taken in the use of mRNA as a therapeutic tool for vaccination. In the following decades, an improved understanding of the mRNA pharmacology, together with novel insights in immunology have positioned mRNA-based technologies as next-generation vaccines. This review outlines the history and current state-of-the-art in mRNA vaccination, while presenting an immunological view on mRNA vaccine development. As such, we highlight the challenges in vaccine design, testing and administration, key considerations in the design of mRNA-based vaccines and new opportunities that arise when packaging mRNA in nanoparticulate vaccines. Finally, we discuss the mRNA self-adjuvant effect as a critical, but dichotomous parameter that determines the safety, efficacy and strength of the evoked immune response." @default.
• W2969814123 created "2019-08-29" @default.
• W2969814123 creator A5004505140 @default.
• W2969814123 creator A5010359444 @default.
• W2969814123 creator A5015695983 @default.
• W2969814123 creator A5052529308 @default.
• W2969814123 date "2019-10-01" @default.
• W2969814123 modified "2023-10-11" @default.
• W2969814123 title "Three decades of messenger RNA vaccine development" @default.
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