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• W2969830046 endingPage "e1008249" @default.
• W2969830046 startingPage "e1008249" @default.
• W2969830046 abstract "Introns are a prevalent feature of eukaryotic genomes, yet their origins and contributions to genome function and evolution remain mysterious. In budding yeast, repression of the highly transcribed intron-containing ribosomal protein genes (RPGs) globally increases splicing of non-RPG transcripts through reduced competition for the spliceosome. We show that under these “hungry spliceosome” conditions, splicing occurs at more than 150 previously unannotated locations we call protointrons that do not overlap known introns. Protointrons use a less constrained set of splice sites and branchpoints than standard introns, including in one case AT-AC in place of GT-AG. Protointrons are not conserved in all closely related species, suggesting that most are not under positive selection and are fated to disappear. Some are found in non-coding RNAs (e. g. CUTs and SUTs), where they may contribute to the creation of new genes. Others are found across boundaries between noncoding and coding sequences, or within coding sequences, where they offer pathways to the creation of new protein variants, or new regulatory controls for existing genes. We define protointrons as (1) nonconserved intron-like sequences that are (2) infrequently spliced, and importantly (3) are not currently understood to contribute to gene expression or regulation in the way that standard introns function. A very few protointrons in S. cerevisiae challenge this classification by their increased splicing frequency and potential function, consistent with the proposed evolutionary process of “intronization”, whereby new standard introns are created. This snapshot of intron evolution highlights the important role of the spliceosome in the expansion of transcribed genomic sequence space, providing a pathway for the rare events that may lead to the birth of new eukaryotic genes and the refinement of existing gene function." @default.
• W2969830046 created "2019-08-29" @default.
• W2969830046 creator A5004039754 @default.
• W2969830046 creator A5028202907 @default.
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• W2969830046 creator A5079187107 @default.
• W2969830046 date "2019-08-22" @default.
• W2969830046 modified "2023-10-17" @default.
• W2969830046 title "Rapidly evolving protointrons in Saccharomyces genomes revealed by a hungry spliceosome" @default.
• W2969830046 cites W1553769217 @default.
• W2969830046 cites W1799432831 @default.
• W2969830046 cites W1913504800 @default.
• W2969830046 cites W1947180815 @default.
• W2969830046 cites W1963604994 @default.
• W2969830046 cites W1968843636 @default.
• W2969830046 cites W1981142077 @default.
• W2969830046 cites W1981187747 @default.
• W2969830046 cites W1987777159 @default.
• W2969830046 cites W1990377497 @default.
• W2969830046 cites W2003861150 @default.
• W2969830046 cites W2008616402 @default.
• W2969830046 cites W2012941238 @default.
• W2969830046 cites W2019104199 @default.
• W2969830046 cites W2024920865 @default.
• W2969830046 cites W2036228528 @default.
• W2969830046 cites W2044042298 @default.
• W2969830046 cites W2049883153 @default.
• W2969830046 cites W2054624670 @default.
• W2969830046 cites W2071726225 @default.
• W2969830046 cites W2074454399 @default.
• W2969830046 cites W2081224211 @default.
• W2969830046 cites W2082047304 @default.
• W2969830046 cites W2082401184 @default.
• W2969830046 cites W2088069070 @default.
• W2969830046 cites W2088364014 @default.
• W2969830046 cites W2102134701 @default.
• W2969830046 cites W2102221598 @default.
• W2969830046 cites W2103434288 @default.
• W2969830046 cites W2103483475 @default.
• W2969830046 cites W2104174145 @default.
• W2969830046 cites W2106311348 @default.
• W2969830046 cites W2106348753 @default.
• W2969830046 cites W2108086419 @default.
• W2969830046 cites W2109362348 @default.
• W2969830046 cites W2110549387 @default.
• W2969830046 cites W2112599840 @default.
• W2969830046 cites W2113030587 @default.
• W2969830046 cites W2115420193 @default.
• W2969830046 cites W2116841494 @default.
• W2969830046 cites W2120185938 @default.
• W2969830046 cites W2127673162 @default.
• W2969830046 cites W2127932826 @default.
• W2969830046 cites W2129147686 @default.
• W2969830046 cites W2133032240 @default.
• W2969830046 cites W2134232237 @default.
• W2969830046 cites W2135757590 @default.
• W2969830046 cites W2136145671 @default.
• W2969830046 cites W2137663617 @default.
• W2969830046 cites W2138854172 @default.
• W2969830046 cites W2139264112 @default.
• W2969830046 cites W2145033158 @default.
• W2969830046 cites W2145191876 @default.
• W2969830046 cites W2149405916 @default.
• W2969830046 cites W2149681259 @default.
• W2969830046 cites W2151478689 @default.
• W2969830046 cites W2152546918 @default.
• W2969830046 cites W2153726105 @default.
• W2969830046 cites W2153833484 @default.
• W2969830046 cites W2157115023 @default.
• W2969830046 cites W2157623749 @default.
• W2969830046 cites W2157980687 @default.
• W2969830046 cites W2158266834 @default.
• W2969830046 cites W2159575202 @default.
• W2969830046 cites W2160243018 @default.
• W2969830046 cites W2160689765 @default.
• W2969830046 cites W2160912561 @default.
• W2969830046 cites W2162098634 @default.
• W2969830046 cites W2162290777 @default.
• W2969830046 cites W2163800294 @default.
• W2969830046 cites W2164819982 @default.
• W2969830046 cites W2169456326 @default.
• W2969830046 cites W2170176918 @default.
• W2969830046 cites W2170344747 @default.
• W2969830046 cites W2170484620 @default.
• W2969830046 cites W2170551349 @default.
• W2969830046 cites W2179438025 @default.
• W2969830046 cites W2196128333 @default.
• W2969830046 cites W2231690295 @default.
• W2969830046 cites W2253933438 @default.
• W2969830046 cites W2331798423 @default.
• W2969830046 cites W2466333954 @default.
• W2969830046 cites W2487016430 @default.
• W2969830046 cites W2528511699 @default.

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