FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2969834516> ?p ?o ?g. }

• W2969834516 endingPage "144" @default.
• W2969834516 startingPage "136" @default.
• W2969834516 abstract "This study evaluated the impact of the interaction between the anorexigenic incretin hormone glucagon-like peptide-1 (GLP-1) and reward-related brain activity in the dorsolateral prefrontal cortex (DLPFC), a key area of behavioral control, on future weight loss in obese individuals.We performed a weight loss-weight maintenance intervention study over 27 months. We applied an fMRI food-cue reactivity paradigm during which the participants were passively exposed to food pictures to evaluate neuronal activity in the DLPFC. Additionally, we measured concentrations of circulating GLP-1 levels during a standard oral glucose tolerance test. Phenotyping was performed consecutively before and after a 3-month low-calorie diet as well as after a randomized 12-month trial, investigating the effect of a combined behavioral intervention on body weight maintenance. Participants were then followed-up for another 12 months without further intervention.Using voxel-wise linear mixed-effects regression analyses, we evaluated 56 measurements and identified a strong interaction between circulating, endogenous GLP-1 levels and DLPFC activity predicting body weight change over the total observation period (t = -6.17, p = 1.6 · 10-7). While neither the GLP-1 nor the DLPFC response individually predicted the subsequent weight change, participants achieved body weight loss when the GLP-1 and the DLPFC responses occurred concurrently.Our data demonstrate an interaction between a peripheral hormonal signal and central nervous activity as robust predictor of body weight change throughout the different periods of a long-term life-style intervention. The preeminent role of their interdependency compared to the partly ambivalent effects of the single components argues for integrative approaches to improve sensitivity and reliability of weight prediction conventionally based on individual biomarkers." @default.
• W2969834516 created "2019-08-29" @default.
• W2969834516 creator A5009569119 @default.
• W2969834516 creator A5013882441 @default.
• W2969834516 creator A5040460070 @default.
• W2969834516 creator A5051868841 @default.
• W2969834516 creator A5076820159 @default.
• W2969834516 creator A5088057932 @default.
• W2969834516 date "2019-11-01" @default.
• W2969834516 modified "2023-10-15" @default.
• W2969834516 title "Interaction of circulating GLP-1 and the response of the dorsolateral prefrontal cortex to food-cues predicts body weight development" @default.
• W2969834516 cites W1783116048 @default.
• W2969834516 cites W1968834784 @default.
• W2969834516 cites W1975756049 @default.
• W2969834516 cites W1976544983 @default.
• W2969834516 cites W1989298659 @default.
• W2969834516 cites W1993305928 @default.
• W2969834516 cites W2013082477 @default.
• W2969834516 cites W2018940614 @default.
• W2969834516 cites W2024754326 @default.
• W2969834516 cites W2030884311 @default.
• W2969834516 cites W2032322539 @default.
• W2969834516 cites W2053946880 @default.
• W2969834516 cites W2065478364 @default.
• W2969834516 cites W2071034945 @default.
• W2969834516 cites W2076140273 @default.
• W2969834516 cites W2078530990 @default.
• W2969834516 cites W2080418085 @default.
• W2969834516 cites W2092103977 @default.
• W2969834516 cites W2096048424 @default.
• W2969834516 cites W2103525547 @default.
• W2969834516 cites W2103655839 @default.
• W2969834516 cites W2105501219 @default.
• W2969834516 cites W2107636058 @default.
• W2969834516 cites W2140477129 @default.
• W2969834516 cites W2140625608 @default.
• W2969834516 cites W2142864721 @default.
• W2969834516 cites W2161555898 @default.
• W2969834516 cites W2167222546 @default.
• W2969834516 cites W2169771266 @default.
• W2969834516 cites W2192544098 @default.
• W2969834516 cites W2255282938 @default.
• W2969834516 cites W2288607028 @default.
• W2969834516 cites W2318252275 @default.
• W2969834516 cites W2330887677 @default.
• W2969834516 cites W2491441607 @default.
• W2969834516 cites W2581264645 @default.
• W2969834516 cites W2609303620 @default.
• W2969834516 cites W2610516457 @default.
• W2969834516 cites W2761362662 @default.
• W2969834516 cites W2781769378 @default.
• W2969834516 cites W2793051428 @default.
• W2969834516 cites W2886024386 @default.
• W2969834516 cites W2892074343 @default.
• W2969834516 cites W2892790565 @default.
• W2969834516 cites W2897840645 @default.
• W2969834516 cites W2898618481 @default.
• W2969834516 cites W2899183711 @default.
• W2969834516 cites W2899646413 @default.
• W2969834516 cites W2938583963 @default.
• W2969834516 doi "https://doi.org/10.1016/j.molmet.2019.08.014" @default.
• W2969834516 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6812034" @default.
• W2969834516 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31668385" @default.
• W2969834516 hasPublicationYear "2019" @default.
• W2969834516 type Work @default.
• W2969834516 sameAs 2969834516 @default.
• W2969834516 citedByCount "11" @default.
• W2969834516 countsByYear W29698345162020 @default.
• W2969834516 countsByYear W29698345162021 @default.
• W2969834516 countsByYear W29698345162022 @default.
• W2969834516 countsByYear W29698345162023 @default.
• W2969834516 crossrefType "journal-article" @default.
• W2969834516 hasAuthorship W2969834516A5009569119 @default.
• W2969834516 hasAuthorship W2969834516A5013882441 @default.
• W2969834516 hasAuthorship W2969834516A5040460070 @default.
• W2969834516 hasAuthorship W2969834516A5051868841 @default.
• W2969834516 hasAuthorship W2969834516A5076820159 @default.
• W2969834516 hasAuthorship W2969834516A5088057932 @default.
• W2969834516 hasBestOaLocation W29698345161 @default.
• W2969834516 hasConcept C126322002 @default.
• W2969834516 hasConcept C134018914 @default.
• W2969834516 hasConcept C15744967 @default.
• W2969834516 hasConcept C169760540 @default.
• W2969834516 hasConcept C169900460 @default.
• W2969834516 hasConcept C2776398474 @default.
• W2969834516 hasConcept C2777180221 @default.
• W2969834516 hasConcept C2778881409 @default.
• W2969834516 hasConcept C2780508717 @default.
• W2969834516 hasConcept C2781195155 @default.
• W2969834516 hasConcept C511355011 @default.
• W2969834516 hasConcept C544821477 @default.
• W2969834516 hasConcept C555293320 @default.
• W2969834516 hasConcept C71924100 @default.
• W2969834516 hasConceptScore W2969834516C126322002 @default.
• W2969834516 hasConceptScore W2969834516C134018914 @default.
• W2969834516 hasConceptScore W2969834516C15744967 @default.
• W2969834516 hasConceptScore W2969834516C169760540 @default.
• W2969834516 hasConceptScore W2969834516C169900460 @default.

• next