FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2969844304> ?p ?o ?g. }

• W2969844304 abstract "Abstract As a kind of natural protein, keratin is widely investigated in the biomedical field. Here, for the first time, a keratin‐based prodrug (PK‐SS‐D) is designed for tumor intracellular reduction triggered drug delivery, by conjugating doxorubicin (DOX) onto poly(ethylene glycol) modified keratin (PEGylated keratin, PK) with a bioreducible disulfide linkage. The protein‐drug conjugate prodrug, with a drug content of 20%, can self‐assemble into micelles with a mean hydrodynamic diameter of 175 nm and a narrow distribution. The in vitro controlled release profiles reveal the reduction triggered thiolated DOX (DOX‐SH) release behavior of the PK‐SS‐D micelles, with a cumulative drug release up to 52% within 10 d in the simulated tumor microenvironment in a sustained releasing mode, and a low drug leakage of 17% in the simulated normal physiological medium. The enhanced tumor growth inhibition of the proposed PK‐SS‐D prodrug micelles is revealed by the methyl tetrazolium (MTT) assays, although the released DOX‐SH prodrug possesses a lower tumor growth inhibition than DOX." @default.
• W2969844304 created "2019-08-29" @default.
• W2969844304 creator A5013663293 @default.
• W2969844304 creator A5073524724 @default.
• W2969844304 date "2019-08-20" @default.
• W2969844304 modified "2023-10-16" @default.
• W2969844304 title "Drug‐Conjugation Induced Self‐Assembly of Feather Keratin‐Based Prodrug for Tumor Intracellular Reduction Triggered Drug Delivery" @default.
• W2969844304 cites W1000377758 @default.
• W2969844304 cites W1167415787 @default.
• W2969844304 cites W1911640022 @default.
• W2969844304 cites W1979632677 @default.
• W2969844304 cites W2074506949 @default.
• W2969844304 cites W2103297649 @default.
• W2969844304 cites W2200680635 @default.
• W2969844304 cites W2227937438 @default.
• W2969844304 cites W2520336538 @default.
• W2969844304 cites W2564872481 @default.
• W2969844304 cites W2577934459 @default.
• W2969844304 cites W2619593007 @default.
• W2969844304 cites W2669862836 @default.
• W2969844304 cites W2763904883 @default.
• W2969844304 cites W2769705286 @default.
• W2969844304 cites W2784332199 @default.
• W2969844304 cites W2792431156 @default.
• W2969844304 cites W2800011841 @default.
• W2969844304 cites W2802381066 @default.
• W2969844304 cites W2804179781 @default.
• W2969844304 cites W2811402315 @default.
• W2969844304 cites W2885402979 @default.
• W2969844304 cites W2887706925 @default.
• W2969844304 cites W2889693220 @default.
• W2969844304 cites W2899503361 @default.
• W2969844304 cites W2899515413 @default.
• W2969844304 cites W2900755194 @default.
• W2969844304 cites W2946272943 @default.
• W2969844304 doi "https://doi.org/10.1002/ppsc.201900189" @default.
• W2969844304 hasPublicationYear "2019" @default.
• W2969844304 type Work @default.
• W2969844304 sameAs 2969844304 @default.
• W2969844304 citedByCount "4" @default.
• W2969844304 countsByYear W29698443042020 @default.
• W2969844304 countsByYear W29698443042021 @default.
• W2969844304 countsByYear W29698443042023 @default.
• W2969844304 crossrefType "journal-article" @default.
• W2969844304 hasAuthorship W2969844304A5013663293 @default.
• W2969844304 hasAuthorship W2969844304A5073524724 @default.
• W2969844304 hasConcept C108215921 @default.
• W2969844304 hasConcept C11268172 @default.
• W2969844304 hasConcept C12554922 @default.
• W2969844304 hasConcept C134306372 @default.
• W2969844304 hasConcept C151730666 @default.
• W2969844304 hasConcept C178790620 @default.
• W2969844304 hasConcept C184651966 @default.
• W2969844304 hasConcept C185592680 @default.
• W2969844304 hasConcept C197336794 @default.
• W2969844304 hasConcept C202751555 @default.
• W2969844304 hasConcept C2776694085 @default.
• W2969844304 hasConcept C2777516009 @default.
• W2969844304 hasConcept C2779820397 @default.
• W2969844304 hasConcept C2780035454 @default.
• W2969844304 hasConcept C2781303535 @default.
• W2969844304 hasConcept C33923547 @default.
• W2969844304 hasConcept C54355233 @default.
• W2969844304 hasConcept C55493867 @default.
• W2969844304 hasConcept C79879829 @default.
• W2969844304 hasConcept C81241287 @default.
• W2969844304 hasConcept C86803240 @default.
• W2969844304 hasConcept C98274493 @default.
• W2969844304 hasConceptScore W2969844304C108215921 @default.
• W2969844304 hasConceptScore W2969844304C11268172 @default.
• W2969844304 hasConceptScore W2969844304C12554922 @default.
• W2969844304 hasConceptScore W2969844304C134306372 @default.
• W2969844304 hasConceptScore W2969844304C151730666 @default.
• W2969844304 hasConceptScore W2969844304C178790620 @default.
• W2969844304 hasConceptScore W2969844304C184651966 @default.
• W2969844304 hasConceptScore W2969844304C185592680 @default.
• W2969844304 hasConceptScore W2969844304C197336794 @default.
• W2969844304 hasConceptScore W2969844304C202751555 @default.
• W2969844304 hasConceptScore W2969844304C2776694085 @default.
• W2969844304 hasConceptScore W2969844304C2777516009 @default.
• W2969844304 hasConceptScore W2969844304C2779820397 @default.
• W2969844304 hasConceptScore W2969844304C2780035454 @default.
• W2969844304 hasConceptScore W2969844304C2781303535 @default.
• W2969844304 hasConceptScore W2969844304C33923547 @default.
• W2969844304 hasConceptScore W2969844304C54355233 @default.
• W2969844304 hasConceptScore W2969844304C55493867 @default.
• W2969844304 hasConceptScore W2969844304C79879829 @default.
• W2969844304 hasConceptScore W2969844304C81241287 @default.
• W2969844304 hasConceptScore W2969844304C86803240 @default.
• W2969844304 hasConceptScore W2969844304C98274493 @default.
• W2969844304 hasIssue "10" @default.
• W2969844304 hasLocation W29698443041 @default.
• W2969844304 hasOpenAccess W2969844304 @default.
• W2969844304 hasPrimaryLocation W29698443041 @default.
• W2969844304 hasRelatedWork W2002024160 @default.
• W2969844304 hasRelatedWork W2016798453 @default.
• W2969844304 hasRelatedWork W2082093834 @default.
• W2969844304 hasRelatedWork W2095582941 @default.
• W2969844304 hasRelatedWork W2273459564 @default.
• W2969844304 hasRelatedWork W2314314165 @default.

• next