Matches in SemOpenAlex for { <https://semopenalex.org/work/W2969851031> ?p ?o ?g. }
- W2969851031 endingPage "1788" @default.
- W2969851031 startingPage "1780" @default.
- W2969851031 abstract "Primary malignant bone tumors are rare, occur in all age groups, and include distinct entities such as osteosarcoma, Ewing sarcoma, and chondrosarcoma. Traditional treatment with some combination of chemotherapy, surgery, and radiation has reached the limit of efficacy, with substantial room for improvement in patient outcome. Furthermore, genomic characterization of these tumors reveals a paucity of actionable molecular targets. Against this backdrop, recent advances in cancer immunotherapy represent a silver lining in the treatment of primary bone cancer. Major strategies in cancer immunotherapy include stimulating naturally occurring anti-tumor T cells and adoptive transfer of tumor-specific cytotoxic T cells. Chimeric antigen receptor T cells (CAR-T cells) belong to the latter strategy and are an impressive application of both insights into T cell biology and advances in genetic engineering. In this review, we briefly describe the CAR-T approach and discuss its applications in primary bone tumors. © 2019 American Society for Bone and Mineral Research." @default.
- W2969851031 created "2019-08-29" @default.
- W2969851031 creator A5047867698 @default.
- W2969851031 creator A5055399960 @default.
- W2969851031 creator A5074097376 @default.
- W2969851031 creator A5076793020 @default.
- W2969851031 creator A5091220137 @default.
- W2969851031 date "2019-10-01" @default.
- W2969851031 modified "2023-09-26" @default.
- W2969851031 title "Primary Bone Tumors: Challenges and Opportunities for CAR‐T Therapies" @default.
- W2969851031 cites W134385904 @default.
- W2969851031 cites W1493925539 @default.
- W2969851031 cites W1838685504 @default.
- W2969851031 cites W1969208169 @default.
- W2969851031 cites W1982795546 @default.
- W2969851031 cites W1994993231 @default.
- W2969851031 cites W2007438323 @default.
- W2969851031 cites W2012707824 @default.
- W2969851031 cites W2013881151 @default.
- W2969851031 cites W2019287405 @default.
- W2969851031 cites W2020604513 @default.
- W2969851031 cites W2021211236 @default.
- W2969851031 cites W2023068069 @default.
- W2969851031 cites W2027863358 @default.
- W2969851031 cites W2038868254 @default.
- W2969851031 cites W2048752843 @default.
- W2969851031 cites W2050302632 @default.
- W2969851031 cites W2051549641 @default.
- W2969851031 cites W2064272625 @default.
- W2969851031 cites W2067988809 @default.
- W2969851031 cites W2073449350 @default.
- W2969851031 cites W2077149593 @default.
- W2969851031 cites W2077871666 @default.
- W2969851031 cites W2094652659 @default.
- W2969851031 cites W2094945699 @default.
- W2969851031 cites W2095097459 @default.
- W2969851031 cites W2102470992 @default.
- W2969851031 cites W2103883600 @default.
- W2969851031 cites W2105443773 @default.
- W2969851031 cites W2110820382 @default.
- W2969851031 cites W2118308733 @default.
- W2969851031 cites W2124328974 @default.
- W2969851031 cites W2124373740 @default.
- W2969851031 cites W2124446900 @default.
- W2969851031 cites W2125028197 @default.
- W2969851031 cites W2127734125 @default.
- W2969851031 cites W2139645959 @default.
- W2969851031 cites W2140334256 @default.
- W2969851031 cites W2140821500 @default.
- W2969851031 cites W2147872295 @default.
- W2969851031 cites W2148334703 @default.
- W2969851031 cites W2148523692 @default.
- W2969851031 cites W2153712501 @default.
- W2969851031 cites W2157003991 @default.
- W2969851031 cites W2178151738 @default.
- W2969851031 cites W2258336271 @default.
- W2969851031 cites W2287148461 @default.
- W2969851031 cites W2305290252 @default.
- W2969851031 cites W2340435799 @default.
- W2969851031 cites W2395676613 @default.
- W2969851031 cites W2517335663 @default.
- W2969851031 cites W2573216598 @default.
- W2969851031 cites W2739972212 @default.
- W2969851031 cites W2763751953 @default.
- W2969851031 cites W2782485041 @default.
- W2969851031 cites W2792949765 @default.
- W2969851031 cites W2793492950 @default.
- W2969851031 cites W2793688609 @default.
- W2969851031 cites W2794795407 @default.
- W2969851031 cites W2796022095 @default.
- W2969851031 cites W2804159084 @default.
- W2969851031 cites W2805523469 @default.
- W2969851031 cites W2807591162 @default.
- W2969851031 cites W2807603420 @default.
- W2969851031 cites W2864786814 @default.
- W2969851031 cites W2888605563 @default.
- W2969851031 cites W2901047766 @default.
- W2969851031 cites W2903981326 @default.
- W2969851031 cites W2906344733 @default.
- W2969851031 cites W2907468621 @default.
- W2969851031 cites W2907702391 @default.
- W2969851031 cites W2911543360 @default.
- W2969851031 cites W4211227438 @default.
- W2969851031 cites W4229737095 @default.
- W2969851031 cites W4247435334 @default.
- W2969851031 cites W925209273 @default.
- W2969851031 doi "https://doi.org/10.1002/jbmr.3852" @default.
- W2969851031 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31441962" @default.
- W2969851031 hasPublicationYear "2019" @default.
- W2969851031 type Work @default.
- W2969851031 sameAs 2969851031 @default.
- W2969851031 citedByCount "12" @default.
- W2969851031 countsByYear W29698510312020 @default.
- W2969851031 countsByYear W29698510312021 @default.
- W2969851031 countsByYear W29698510312022 @default.
- W2969851031 countsByYear W29698510312023 @default.
- W2969851031 crossrefType "journal-article" @default.
- W2969851031 hasAuthorship W2969851031A5047867698 @default.