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• W2969852010 abstract "Purpose: In spite of extensive studies, the mechanism of cardiopulmonary resuscitation (CPR) has not beenproperly understood and a proper comprehension of the role of regulatory mechanisms of the cardiovascularsystem during CPR is unavailable. Using computational methods, we try to study the influence ofsympathetic activation on the cardiac output and mean arterial pressure (MAP) during CPR at differentcompression pressures and rates.Methods: A computer model was used to investigate the effect of sympathetic activation during CPR. Themodel has a detailed representation of the cardiopulmonary resuscitation system and sympathetic control.Sympathetic activation during CPR was achieved through vital cardiac parameters such as contractility andperipheral resistance. We compared the cardiac output and MAP during CPR in four scenarios, namely with;(1) sympathetic activation of heart alone, (2) sympathetic activation of the peripheral arteries alone, (3)sympathetic activation of both heart and peripheral arteries, and (4) no sympathetic activation; for differentcompression pressures and rates.Results: The results show that the cardiac output and MAP increases with increasing compression pressuresand rates during CPR with sympathetic activation of peripheral arteries. The sympathetic activation ofperipheral arteries during CPR at the AHA and ERC recommended chest compression pressures and ratesresulted in an increased MAP, an augmented aortic diastolic pressure and a decreased cardiac output. Theresults also show that cardiac output and MAP pressure increases with increasing compression rate duringCPR with sympathetic activation of heart. There is a slight increase in the MAP but no substantialimprovement in cardiac output during CPR with sympathetic activation of heart at the AHA and ERCrecommended pressures and rates.Conclusions: It is observed from the study that sympathetic activation of heart during CPR may not bebeneficial at the AHA and ERC recommended chest compression rates as it gives very little improvementin cardiac output and MAP. However, performing CPR at higher compression rate may improve the chancesof resuscitation when drugs are used to induce sympathetic activity in the heart. The augmented aorticdiastolic pressure during CPR with sympathetic activation of peripheral arteries at the AHA and ERCrecommended compression pressure and rates can improve the myocardial perfusion, but the reducedcardiac output is a cause of concern." @default.
• W2969852010 created "2019-08-29" @default.
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• W2969852010 date "2018-12-23" @default.
• W2969852010 modified "2023-10-16" @default.
• W2969852010 title "A Computer-based Study on the Effect of Sympathetic Activity during CPR" @default.
• W2969852010 doi "https://doi.org/10.31487/j.jicoa.2018.01.004" @default.
• W2969852010 hasPublicationYear "2018" @default.
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