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• W2969852705 endingPage "172762" @default.
• W2969852705 startingPage "172762" @default.
• W2969852705 abstract "The majority of synthetic cathinone research has used only male subjects, and as a result there are few studies assessing the impact of biological sex on their effects. The current work extends the characterization of the second-generation synthetic cathinone, α-PVP, by investigating how biological sex impacts α-PVP's aversive and rewarding effects important to its use and potential abuse. A combined conditioned taste avoidance/conditioned place preference preparation was utilized in which adult male and female Sprague Dawley rats were injected with 1.5, 3 or 6 mg/kg of racemic α-PVP or vehicle (saline) (IP). Following a 24-day washout period, rats were then tested for thermoregulatory effects of α-PVP using subcutaneous microchips to measure body temperature changes over the course of 8 h. This was followed 21 days later by assessments for α-PVP-induced locomotor activity and stereotypies over a 1-h session. Dose-dependent conditioned taste avoidance was evident in both males and females, although females displayed weaker avoidance at 3 mg/kg compared to males. Males displayed a dose-dependent conditioned place preference, while females did not form a place preference at any dose. α-PVP elicited dose- and time-dependent hyperthermia, with males displaying a faster on-set and delayed off-set compared to females. α-PVP also produced dose- and time-dependent increases in locomotor activity (F > M) and stereotypies (M > F). As described, males displayed greater rewarding (as indexed by place preference conditioning) and aversive (as indexed by taste avoidance, hyperthermia and stereotypies) effects of α-PVP. Although comparisons between males and females in α-PVP self-administration have not been reported, these data suggest that males may be more likely to use the drug. The implications for sex differences in human use of α-PVP were discussed." @default.
• W2969852705 created "2019-08-29" @default.
• W2969852705 creator A5028434959 @default.
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• W2969852705 creator A5060799349 @default.
• W2969852705 creator A5072565784 @default.
• W2969852705 date "2019-10-01" @default.
• W2969852705 modified "2023-10-16" @default.
• W2969852705 title "Sex differences in α-pyrrolidinopentiophenone (α-PVP)-induced taste avoidance, place preference, hyperthermia and locomotor activity in rats" @default.
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• W2969852705 doi "https://doi.org/10.1016/j.pbb.2019.172762" @default.
• W2969852705 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6748333" @default.
• W2969852705 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31445057" @default.
• W2969852705 hasPublicationYear "2019" @default.
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