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- W2969854837 abstract "Sepsis is a complex disease that begins with an infectious disorder and causes excessive immune responses. Curcumin is considered as an active component of turmeric that can improve the condition in sepsis due to its anti‐inflammatory and antioxidant properties. PubMed, Embase, Google Scholar, Web of Science, and Scopus databases were searched. Searching was not limited to a specific publication period. Only English‐language original articles, which had examined the effect of curcumin on sepsis, were included. At first, 1,098 articles were totally found, and 209 articles were selected after excluding duplicated data; 46 articles were remained due to the curcumin effects on sepsis. These included 23 in vitro studies and 23 animal studies. Our results showed that curcumin and various analogs of curcumin can have an inhibitory effect on sepsis‐induced complications. Curcumin has the ability to inhibit the inflammatory, oxidative coagulation factors, and regulation of immune responses in sepsis. Despite the promising evidence of the therapeutic effects of curcumin on the sepsis complication, further studies seem necessary to investigate its effect and possible mechanisms of action in human studies." @default.
- W2969854837 created "2019-08-29" @default.
- W2969854837 creator A5007948256 @default.
- W2969854837 creator A5017641662 @default.
- W2969854837 creator A5021553196 @default.
- W2969854837 creator A5042967477 @default.
- W2969854837 creator A5068714539 @default.
- W2969854837 creator A5086385521 @default.
- W2969854837 date "2019-08-19" @default.
- W2969854837 modified "2023-10-02" @default.
- W2969854837 title "Therapeutic effects of curcumin on sepsis and mechanisms of action: A systematic review of preclinical studies" @default.
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