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- W2969856544 abstract "Tumors have aberrant proteomes that often do not match their corresponding transcriptome profiles. One possible cause of this discrepancy is the existence of aberrant RNA modification landscapes in the so-called epitranscriptome. Here, we report that human glioma cells undergo DNA methylation-associated epigenetic silencing of NSUN5, a candidate RNA methyltransferase for 5-methylcytosine. In this setting, NSUN5 exhibits tumor-suppressor characteristics in vivo glioma models. We also found that NSUN5 loss generates an unmethylated status at the C3782 position of 28S rRNA that drives an overall depletion of protein synthesis, and leads to the emergence of an adaptive translational program for survival under conditions of cellular stress. Interestingly, NSUN5 epigenetic inactivation also renders these gliomas sensitive to bioactivatable substrates of the stress-related enzyme NQO1. Most importantly, NSUN5 epigenetic inactivation is a hallmark of glioma patients with long-term survival for this otherwise devastating disease." @default.
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- W2969856544 date "2019-08-19" @default.
- W2969856544 modified "2023-10-18" @default.
- W2969856544 title "Epigenetic loss of RNA-methyltransferase NSUN5 in glioma targets ribosomes to drive a stress adaptive translational program" @default.
- W2969856544 cites W1608233475 @default.
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- W2969856544 cites W1965163574 @default.
- W2969856544 cites W1965262464 @default.
- W2969856544 cites W1969524738 @default.
- W2969856544 cites W1973268693 @default.
- W2969856544 cites W1976616802 @default.
- W2969856544 cites W1985524011 @default.
- W2969856544 cites W2008121312 @default.
- W2969856544 cites W2021061167 @default.
- W2969856544 cites W2022582116 @default.
- W2969856544 cites W2039171339 @default.
- W2969856544 cites W2042418666 @default.
- W2969856544 cites W2052897160 @default.
- W2969856544 cites W2060902122 @default.
- W2969856544 cites W2062696188 @default.
- W2969856544 cites W2076772609 @default.
- W2969856544 cites W2082519344 @default.
- W2969856544 cites W2084397697 @default.
- W2969856544 cites W2087249772 @default.
- W2969856544 cites W2089716875 @default.
- W2969856544 cites W2096944819 @default.
- W2969856544 cites W2105100844 @default.
- W2969856544 cites W2105528101 @default.
- W2969856544 cites W2106810485 @default.
- W2969856544 cites W2114172458 @default.
- W2969856544 cites W2117036448 @default.
- W2969856544 cites W2124951199 @default.
- W2969856544 cites W2126360553 @default.
- W2969856544 cites W2132392209 @default.
- W2969856544 cites W2135084132 @default.
- W2969856544 cites W2155060633 @default.
- W2969856544 cites W2156021317 @default.
- W2969856544 cites W2156196125 @default.
- W2969856544 cites W2177366015 @default.