FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2969856904> ?p ?o ?g. }

• W2969856904 endingPage "3381" @default.
• W2969856904 startingPage "3372" @default.
• W2969856904 abstract "Bacterial cellulose nanofiber (CNF) is a polymer with a wide range of potential industrial applications. Several Komagataeibacter species, including Komagataeibacter xylinus as a model organism, produce CNF. However, the industrial application of CNF has been hampered by inefficient CNF production, necessitating metabolic engineering for the enhanced CNF production. Here, we present complete genome sequence and a genome-scale metabolic model KxyMBEL1810 of K. xylinus DSM 2325 for metabolic engineering applications. Genome analysis of this bacterium revealed that a set of genes associated with CNF biosynthesis and regulation were present in this bacterium, which were also conserved in another six representative Komagataeibacter species having complete genome information. To better understand the metabolic characteristics of K. xylinus DSM 2325, KxyMBEL1810 was reconstructed using genome annotation data, relevant computational resources and experimental growth data generated in this study. Random sampling and correlation analysis of the KxyMBEL1810 predicted pgi and gnd genes as novel overexpression targets for the enhanced CNF production. Among engineered K. xylinus strains individually overexpressing heterologous pgi and gnd genes, either from Escherichia coli or Corynebacterium glutamicum, batch fermentation of a strain overexpressing the E. coli pgi gene produced 3.15 g/L of CNF in a complex medium containing glucose, which was the best CNF concentration achieved in this study, and 115.8% higher than that (1.46 g/L) obtained from the control strain. Genome sequence data and KxyMBEL1810 generated in this study should be useful resources for metabolic engineering of K. xylinus for the enhanced CNF production." @default.
• W2969856904 created "2019-08-29" @default.
• W2969856904 creator A5008430104 @default.
• W2969856904 creator A5025777654 @default.
• W2969856904 creator A5047156899 @default.
• W2969856904 creator A5048072583 @default.
• W2969856904 creator A5053082301 @default.
• W2969856904 creator A5054096882 @default.
• W2969856904 creator A5088406723 @default.
• W2969856904 date "2019-09-03" @default.
• W2969856904 modified "2023-10-03" @default.
• W2969856904 title "Genomic and metabolic analysis of<i>Komagataeibacter xylinus</i>DSM 2325 producing bacterial cellulose nanofiber" @default.
• W2969856904 cites W1520371946 @default.
• W2969856904 cites W1565475717 @default.
• W2969856904 cites W1908709110 @default.
• W2969856904 cites W1952732684 @default.
• W2969856904 cites W1964628524 @default.
• W2969856904 cites W1977897382 @default.
• W2969856904 cites W1983403167 @default.
• W2969856904 cites W1983502697 @default.
• W2969856904 cites W2016135255 @default.
• W2969856904 cites W2019516978 @default.
• W2969856904 cites W2033384876 @default.
• W2969856904 cites W2034369373 @default.
• W2969856904 cites W2042131639 @default.
• W2969856904 cites W2042657986 @default.
• W2969856904 cites W2044892321 @default.
• W2969856904 cites W2047421251 @default.
• W2969856904 cites W2048080311 @default.
• W2969856904 cites W2048465561 @default.
• W2969856904 cites W2051918911 @default.
• W2969856904 cites W2080119168 @default.
• W2969856904 cites W2082561535 @default.
• W2969856904 cites W2085993965 @default.
• W2969856904 cites W2092243213 @default.
• W2969856904 cites W2119642783 @default.
• W2969856904 cites W2120902911 @default.
• W2969856904 cites W2128601422 @default.
• W2969856904 cites W2130178661 @default.
• W2969856904 cites W2131366108 @default.
• W2969856904 cites W2132842643 @default.
• W2969856904 cites W2139413502 @default.
• W2969856904 cites W2142402047 @default.
• W2969856904 cites W2149569030 @default.
• W2969856904 cites W2158677343 @default.
• W2969856904 cites W2170427655 @default.
• W2969856904 cites W2187650526 @default.
• W2969856904 cites W2202347610 @default.
• W2969856904 cites W2217317199 @default.
• W2969856904 cites W2311203695 @default.
• W2969856904 cites W2465468898 @default.
• W2969856904 cites W2470052926 @default.
• W2969856904 cites W2559588208 @default.
• W2969856904 cites W2592321159 @default.
• W2969856904 cites W2615590324 @default.
• W2969856904 cites W2620432578 @default.
• W2969856904 cites W2672642559 @default.
• W2969856904 cites W2735467490 @default.
• W2969856904 cites W2744896740 @default.
• W2969856904 cites W2751595532 @default.
• W2969856904 cites W2765646554 @default.
• W2969856904 cites W2805229742 @default.
• W2969856904 cites W2898194784 @default.
• W2969856904 doi "https://doi.org/10.1002/bit.27150" @default.
• W2969856904 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31433066" @default.
• W2969856904 hasPublicationYear "2019" @default.
• W2969856904 type Work @default.
• W2969856904 sameAs 2969856904 @default.
• W2969856904 citedByCount "42" @default.
• W2969856904 countsByYear W29698569042019 @default.
• W2969856904 countsByYear W29698569042020 @default.
• W2969856904 countsByYear W29698569042021 @default.
• W2969856904 countsByYear W29698569042022 @default.
• W2969856904 countsByYear W29698569042023 @default.
• W2969856904 crossrefType "journal-article" @default.
• W2969856904 hasAuthorship W2969856904A5008430104 @default.
• W2969856904 hasAuthorship W2969856904A5025777654 @default.
• W2969856904 hasAuthorship W2969856904A5047156899 @default.
• W2969856904 hasAuthorship W2969856904A5048072583 @default.
• W2969856904 hasAuthorship W2969856904A5053082301 @default.
• W2969856904 hasAuthorship W2969856904A5054096882 @default.
• W2969856904 hasAuthorship W2969856904A5088406723 @default.
• W2969856904 hasConcept C104317684 @default.
• W2969856904 hasConcept C105702510 @default.
• W2969856904 hasConcept C141231307 @default.
• W2969856904 hasConcept C185592680 @default.
• W2969856904 hasConcept C2776260651 @default.
• W2969856904 hasConcept C2778022156 @default.
• W2969856904 hasConcept C2779251873 @default.
• W2969856904 hasConcept C2779477270 @default.
• W2969856904 hasConcept C523546767 @default.
• W2969856904 hasConcept C54355233 @default.
• W2969856904 hasConcept C547475151 @default.
• W2969856904 hasConcept C55493867 @default.
• W2969856904 hasConcept C6350086 @default.
• W2969856904 hasConcept C70721500 @default.
• W2969856904 hasConcept C86803240 @default.
• W2969856904 hasConceptScore W2969856904C104317684 @default.

• next