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• W2969864448 abstract "RNA modification meets immune metabolism N 6 -methyladenosine (m 6 A) RNA modification regulates various cellular functions. Liu et al. found that host cells impair RNA m 6 A demethylase activity after viral infection, leading to increased m 6 A and reduced stability of α-ketoglutarate dehydrogenase (OGDH) mRNA. As a result, reduced OGDH decreases the generation of itaconate, thereby inhibiting viral replication. The authors explore the function of OGDH and itaconate in viral infection, provide insights into m 6 A RNA modification and metabolic reprogramming in modulating virus-host interaction, and suggest potential therapeutic targets for the control of viral infection. Science , this issue p. 1171" @default.
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• W2969864448 date "2019-09-13" @default.
• W2969864448 modified "2023-10-14" @default.
• W2969864448 title "<i>N</i> ⁶ -methyladenosine RNA modification–mediated cellular metabolism rewiring inhibits viral replication" @default.
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• W2969864448 doi "https://doi.org/10.1126/science.aax4468" @default.
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