FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2969874569> ?p ?o ?g. }

• W2969874569 abstract "Abstract The bundle of stereocilia on inner ear hair cells responds to subnanometer deflections produced by sound or head movement. Stereocilia are interconnected by a variety of links and also carry an electron-dense surface coat. The coat may contribute to stereocilia adhesion or protect from stereocilia fusion, but its molecular identity remains unknown. From a database of hair-cell-enriched translated proteins, we identify Polycystic Kidney and Hepatic Disease 1-Like 1 (PKHD1L1), a large, mostly extracellular protein of 4249 amino acids with a single transmembrane domain. Using serial immunogold scanning electron microscopy, we show that PKHD1L1 is expressed at the tips of stereocilia, especially in the high-frequency regions of the cochlea. PKHD1L1-deficient mice lack the surface coat at the upper but not lower regions of stereocilia, and they develop progressive hearing loss. We conclude that PKHD1L1 is a component of the surface coat and is required for normal hearing in mice." @default.
• W2969874569 created "2019-08-29" @default.
• W2969874569 creator A5000553395 @default.
• W2969874569 creator A5029778986 @default.
• W2969874569 creator A5039279042 @default.
• W2969874569 creator A5072403700 @default.
• W2969874569 creator A5079604577 @default.
• W2969874569 creator A5081441104 @default.
• W2969874569 date "2019-08-23" @default.
• W2969874569 modified "2023-10-17" @default.
• W2969874569 title "PKHD1L1 is a coat protein of hair-cell stereocilia and is required for normal hearing" @default.
• W2969874569 cites W1536809181 @default.
• W2969874569 cites W1595484672 @default.
• W2969874569 cites W1710709677 @default.
• W2969874569 cites W1967884351 @default.
• W2969874569 cites W1974480098 @default.
• W2969874569 cites W1982452191 @default.
• W2969874569 cites W1995782088 @default.
• W2969874569 cites W1996702954 @default.
• W2969874569 cites W2001452730 @default.
• W2969874569 cites W2006351007 @default.
• W2969874569 cites W2018192312 @default.
• W2969874569 cites W2018385101 @default.
• W2969874569 cites W2019332518 @default.
• W2969874569 cites W2021285999 @default.
• W2969874569 cites W2024892054 @default.
• W2969874569 cites W2038000805 @default.
• W2969874569 cites W2041299611 @default.
• W2969874569 cites W2047411145 @default.
• W2969874569 cites W2049458280 @default.
• W2969874569 cites W2056781179 @default.
• W2969874569 cites W2060460282 @default.
• W2969874569 cites W2061038984 @default.
• W2969874569 cites W2062945625 @default.
• W2969874569 cites W2063341353 @default.
• W2969874569 cites W2073137995 @default.
• W2969874569 cites W2075739422 @default.
• W2969874569 cites W2075772363 @default.
• W2969874569 cites W2092597147 @default.
• W2969874569 cites W2093083290 @default.
• W2969874569 cites W2093298785 @default.
• W2969874569 cites W2097498366 @default.
• W2969874569 cites W2098211196 @default.
• W2969874569 cites W2102252823 @default.
• W2969874569 cites W2112106734 @default.
• W2969874569 cites W2113278451 @default.
• W2969874569 cites W2126146127 @default.
• W2969874569 cites W2128055507 @default.
• W2969874569 cites W2130717810 @default.
• W2969874569 cites W2133030978 @default.
• W2969874569 cites W2140344774 @default.
• W2969874569 cites W2146152985 @default.
• W2969874569 cites W2146940582 @default.
• W2969874569 cites W2155652989 @default.
• W2969874569 cites W2156756252 @default.
• W2969874569 cites W2164240678 @default.
• W2969874569 cites W2312663043 @default.
• W2969874569 cites W2516956185 @default.
• W2969874569 cites W2906903141 @default.
• W2969874569 cites W76934572 @default.
• W2969874569 doi "https://doi.org/10.1038/s41467-019-11712-w" @default.
• W2969874569 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6707252" @default.
• W2969874569 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31444330" @default.
• W2969874569 hasPublicationYear "2019" @default.
• W2969874569 type Work @default.
• W2969874569 sameAs 2969874569 @default.
• W2969874569 citedByCount "17" @default.
• W2969874569 countsByYear W29698745692020 @default.
• W2969874569 countsByYear W29698745692021 @default.
• W2969874569 countsByYear W29698745692022 @default.
• W2969874569 countsByYear W29698745692023 @default.
• W2969874569 crossrefType "journal-article" @default.
• W2969874569 hasAuthorship W2969874569A5000553395 @default.
• W2969874569 hasAuthorship W2969874569A5029778986 @default.
• W2969874569 hasAuthorship W2969874569A5039279042 @default.
• W2969874569 hasAuthorship W2969874569A5072403700 @default.
• W2969874569 hasAuthorship W2969874569A5079604577 @default.
• W2969874569 hasAuthorship W2969874569A5081441104 @default.
• W2969874569 hasBestOaLocation W29698745691 @default.
• W2969874569 hasConcept C105702510 @default.
• W2969874569 hasConcept C11658465 @default.
• W2969874569 hasConcept C151730666 @default.
• W2969874569 hasConcept C2776557274 @default.
• W2969874569 hasConcept C2777817576 @default.
• W2969874569 hasConcept C2778500370 @default.
• W2969874569 hasConcept C2778585322 @default.
• W2969874569 hasConcept C2780130748 @default.
• W2969874569 hasConcept C30030713 @default.
• W2969874569 hasConcept C86803240 @default.
• W2969874569 hasConcept C87555872 @default.
• W2969874569 hasConcept C95444343 @default.
• W2969874569 hasConceptScore W2969874569C105702510 @default.
• W2969874569 hasConceptScore W2969874569C11658465 @default.
• W2969874569 hasConceptScore W2969874569C151730666 @default.
• W2969874569 hasConceptScore W2969874569C2776557274 @default.
• W2969874569 hasConceptScore W2969874569C2777817576 @default.
• W2969874569 hasConceptScore W2969874569C2778500370 @default.
• W2969874569 hasConceptScore W2969874569C2778585322 @default.
• W2969874569 hasConceptScore W2969874569C2780130748 @default.
• W2969874569 hasConceptScore W2969874569C30030713 @default.

• next