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- W2969881775 abstract "Inter-individual differences in serum α-tocopherol (α-toc) concentrations may be due, in part, to genetic variations in α-toc metabolism. The objective was to determine whether common polymorphisms in the α-tocopherol transfer protein (α-TTP) (rs6994076, T>A) and tocopherol associated protein (TAP) (rs2072157, C>T) genes influence serum α-toc concentrations or modify the association between dietary and serum α-toc. Subjects (n=449) between the ages of 20 and 29 years completed a food frequency questionnaire and provided a fasting blood sample for genotyping and measuring serum α-toc by HPLC. Differences in serum α-toc were observed between α-TTP genotypes (p=0.03), but only when supplement users were excluded. No differences in serum α-toc were observed between TAP genotypes. No significant interactions were observed between dietary α-toc and either α-TTP or TAP genotype on serum α-toc, regardless of supplement use. When supplement users were included, the correlation co-efficient (P-value) between dietary and serum α-toc for the TAP C/C, C/T and T/T genotypes was 0.24 (0.002), 0.20 (0.006) and 0.45 (0.002), respectively. When supplement users were excluded, the corresponding correlations were 0.05 (0.57), 0.12 (0.18) and 0.53 (0.003). These findings suggest that α-TTP may influence fasting serum α-toc concentrations and TAP may modify the strength of the association between diet and serum α-toc. Grant Funding Source Advanced Foods and Material Network" @default.
- W2969881775 created "2019-08-29" @default.
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- W2969881775 date "2009-04-01" @default.
- W2969881775 modified "2023-09-27" @default.
- W2969881775 title "Gene‐diet interactions and serum α‐tocopherol concentrations" @default.
- W2969881775 doi "https://doi.org/10.1096/fasebj.23.1_supplement.725.6" @default.
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