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- W2969883075 abstract "Stability study of biological products especially living bacterial vaccines playsan important role for the determination of product changes in maintenanceperiod, and ensures safety, efficacy and maintenance of biologicalproperties of the vaccines. So, the objective of this study was to establishstability and keeping quality of the local Brucella melitensis Rev-1 vaccineusing different types of stabilizers in lyophilization process. A long-termstability study was carried out for four batches of reduced-dose Brucellamelitensis Rev-1 vaccine manufactured by veterinary serum and vaccineresearch institute using four different stabilizers. Stabilizers were: (A)sucrose and skimmed milk, (B and C) different concentrations of sucrose,sodium glutamate and gelatin, and (D) casein, sucrose and sodiumglutamate. The quality control tests including colony forming unit, purity,dissociation and physicochemical tests on all batches until 12 months postproduction were performed. The obtained results indicated that in spite ofcollapse (shrinkage) of lyophilized cake in a number of bottles in batchesprepared using stabilizer A, Brucella vaccine batches were stable and metthe specification recommended by OIE 2012 for 12 months post-productionin vaccine batches with stabilizers A and D." @default.
- W2969883075 created "2019-08-29" @default.
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- W2969883075 date "2018-06-01" @default.
- W2969883075 modified "2023-09-24" @default.
- W2969883075 title "The use of different stabilizers for improving integrity of the locally prepared lyophilized Brucella melitensis Rev 1 vaccine" @default.
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- W2969883075 doi "https://doi.org/10.21608/jvmr.2018.43302" @default.
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