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- W2969892844 abstract "Esophageal cancer (EC) is associated with a poor prognosis, particularly so in Africa where an alarmingly high mortality to incidence ratio prevails for this disease.To provide further understanding of EC in the context of the unique cultural and genetic diversity, and socio-economic challenges faced on the African continent.We performed a systematic review of studies from Africa to obtain data on epidemiology, risk factors, management and outcomes of EC. A non-systematic review was used to obtain incidence data from the International Agency for Research on Cancer, and the Cancer in Sub-Saharan reports. We searched EMBASE, PubMed, Web of Science, and Cochrane Central from inception to March 2019 and reviewed the list of articles retrieved. Random effects meta-analyses were used to assess heterogeneity between studies and to obtain odds ratio (OR) of the associations between EC and risk factors; and incidence rate ratios for EC between sexes with their respective 95% confidence intervals (CI).The incidence of EC is higher in males than females, except in North Africa where it is similar for both sexes. The highest age-standardized rate is from Malawi (30.3 and 19.4 cases/year/100000 population for males and females, respectively) followed by Kenya (28.7 cases/year/100000 population for both sexes). The incidence of EC rises sharply after the age of 40 years and reaches a peak at 75 years old. Meta-analysis shows a strong association with tobacco (OR 3.15, 95%CI: 2.83-3.50). There was significant heterogeneity between studies on alcohol consumption (OR 2.28, 95%CI: 1.94-2.65) and on low socioeconomic status (OR 139, 95%CI: 1.25-1.54) as risk factors, but these could also contribute to increasing the incidence of EC. The best treatment outcomes were with esophagectomy with survival rates of 76.6% at 3 years, and chemo-radiotherapy with an overall combined survival time of 267.50 d.Africa has high incidence and mortality rates of EC, with preventable and non-modifiable risk factors. Men in this setting are at increased risk due to their higher prevalence of tobacco and alcohol consumption. Management requires a multidisciplinary approach, and survival is significantly improved in the setting of esophagectomy and chemoradiation therapy." @default.
- W2969892844 created "2019-08-29" @default.
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- W2969892844 date "2019-08-21" @default.
- W2969892844 modified "2023-10-14" @default.
- W2969892844 title "Systematic review of esophageal cancer in Africa: Epidemiology, risk factors, management and outcomes" @default.
- W2969892844 cites W1046674253 @default.
- W2969892844 cites W122296733 @default.
- W2969892844 cites W1483063522 @default.
- W2969892844 cites W1552083704 @default.
- W2969892844 cites W1567352500 @default.
- W2969892844 cites W1591562928 @default.
- W2969892844 cites W1753968347 @default.
- W2969892844 cites W1825504453 @default.
- W2969892844 cites W1878172041 @default.
- W2969892844 cites W1943428871 @default.
- W2969892844 cites W1951384825 @default.
- W2969892844 cites W1964871748 @default.
- W2969892844 cites W1966219148 @default.
- W2969892844 cites W1966920092 @default.
- W2969892844 cites W1967418263 @default.
- W2969892844 cites W1975840453 @default.
- W2969892844 cites W1976092321 @default.
- W2969892844 cites W1981838998 @default.
- W2969892844 cites W1984750939 @default.
- W2969892844 cites W1990453634 @default.
- W2969892844 cites W1992864737 @default.
- W2969892844 cites W2000067099 @default.
- W2969892844 cites W2000839532 @default.
- W2969892844 cites W20036148 @default.
- W2969892844 cites W2006180790 @default.
- W2969892844 cites W2006200510 @default.
- W2969892844 cites W2008071593 @default.
- W2969892844 cites W2008751692 @default.
- W2969892844 cites W2009057064 @default.
- W2969892844 cites W2009508105 @default.
- W2969892844 cites W2010945003 @default.
- W2969892844 cites W2014473134 @default.
- W2969892844 cites W2015871659 @default.
- W2969892844 cites W2021098582 @default.
- W2969892844 cites W2033267897 @default.
- W2969892844 cites W2033727131 @default.
- W2969892844 cites W2034630385 @default.
- W2969892844 cites W2036336132 @default.
- W2969892844 cites W2038282633 @default.
- W2969892844 cites W2039213368 @default.
- W2969892844 cites W2041582053 @default.
- W2969892844 cites W2043610975 @default.
- W2969892844 cites W2045866057 @default.
- W2969892844 cites W2048828215 @default.
- W2969892844 cites W2052346770 @default.
- W2969892844 cites W2056089844 @default.
- W2969892844 cites W2058453298 @default.
- W2969892844 cites W2058530994 @default.
- W2969892844 cites W2060412468 @default.
- W2969892844 cites W2060484827 @default.
- W2969892844 cites W2061198956 @default.
- W2969892844 cites W2062145209 @default.
- W2969892844 cites W2065823699 @default.
- W2969892844 cites W2067152841 @default.
- W2969892844 cites W2067940743 @default.
- W2969892844 cites W2074287451 @default.
- W2969892844 cites W2077360742 @default.
- W2969892844 cites W2077376469 @default.
- W2969892844 cites W2077707316 @default.
- W2969892844 cites W2077929154 @default.
- W2969892844 cites W2080566161 @default.
- W2969892844 cites W2083224887 @default.
- W2969892844 cites W2084726376 @default.
- W2969892844 cites W2084995763 @default.
- W2969892844 cites W2091275380 @default.
- W2969892844 cites W2092184970 @default.
- W2969892844 cites W2096013960 @default.
- W2969892844 cites W2101953677 @default.
- W2969892844 cites W2103246760 @default.
- W2969892844 cites W2106133858 @default.
- W2969892844 cites W2107534342 @default.
- W2969892844 cites W2108764636 @default.
- W2969892844 cites W2112800524 @default.
- W2969892844 cites W2114287139 @default.
- W2969892844 cites W2121241419 @default.
- W2969892844 cites W2123065342 @default.
- W2969892844 cites W2124702914 @default.
- W2969892844 cites W2126930838 @default.
- W2969892844 cites W2129151799 @default.
- W2969892844 cites W2134797153 @default.
- W2969892844 cites W2137680956 @default.
- W2969892844 cites W2139175608 @default.
- W2969892844 cites W2140612010 @default.
- W2969892844 cites W2148712894 @default.