Matches in SemOpenAlex for { <https://semopenalex.org/work/W2969893755> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W2969893755 endingPage "310" @default.
- W2969893755 startingPage "302" @default.
- W2969893755 abstract "The aim of this study was to investigate efficacy and safety of released-active antibodies against interferon-gamma, CD4-receptor, and histamine in adult patients with acute respiratory viral infection (ARVI). Methods . This multicenter, randomized, double-blind, placebo-controlled clinical trial in parallel groups was carried out in 2011 – 2012. Data of 161 ambulatory patients from 4 centers at Russian Federation were included in the analysis. The patients' age was 18 to 60 years. Patients with ARVI signs duration ≤ 48 hours were enrolled in the study. The patients were randomly assigned for the treatment with released-active antibodies against IFN-γ, CD4-receptor, and histamine (the active treatment group; n = 76), or placebo (placebo group; n = 85) for 5 days at 1:1 ratio. The randomization was made using the block randomization method. The treatment efficacy was evaluated according to number of patients with normal body temperature (≤ 37.0 °C) over 5 days of the treatment. Additionally, we evaluated the need in antipyretics, duration and severity of clinical symptoms and complications. Results . During the treatment period, the number of patients with normal body temperature was higher in the active treatment group. Additionally, patients of this group needed antipyretics less often compared to the placebo group. Deterioration and complicated course of the disease were not registered in the active treatment group compared to the placebo group. Conclusion . The results of this multicenter, randomized, double-blind, placebo-controlled clinical trial in parallel groups demonstrated therapeutic efficacy and safety of released-active antibodies against IFN-γ, CD4-receptor, and histamine in adult patients with acute respiratory viral infection." @default.
- W2969893755 created "2019-08-29" @default.
- W2969893755 creator A5000545987 @default.
- W2969893755 creator A5002632971 @default.
- W2969893755 creator A5041267421 @default.
- W2969893755 creator A5060213150 @default.
- W2969893755 creator A5080638327 @default.
- W2969893755 date "2019-08-17" @default.
- W2969893755 modified "2023-10-16" @default.
- W2969893755 title "Results of a randomized, double-blind, placebo-controlled clinical trial in adult patients with acute respiratory viral infection" @default.
- W2969893755 doi "https://doi.org/10.18093/0869-0189-2019-29-3-302-310" @default.
- W2969893755 hasPublicationYear "2019" @default.
- W2969893755 type Work @default.
- W2969893755 sameAs 2969893755 @default.
- W2969893755 citedByCount "2" @default.
- W2969893755 countsByYear W29698937552019 @default.
- W2969893755 countsByYear W29698937552021 @default.
- W2969893755 crossrefType "journal-article" @default.
- W2969893755 hasAuthorship W2969893755A5000545987 @default.
- W2969893755 hasAuthorship W2969893755A5002632971 @default.
- W2969893755 hasAuthorship W2969893755A5041267421 @default.
- W2969893755 hasAuthorship W2969893755A5060213150 @default.
- W2969893755 hasAuthorship W2969893755A5080638327 @default.
- W2969893755 hasBestOaLocation W29698937551 @default.
- W2969893755 hasConcept C126322002 @default.
- W2969893755 hasConcept C142724271 @default.
- W2969893755 hasConcept C168563851 @default.
- W2969893755 hasConcept C202061045 @default.
- W2969893755 hasConcept C204243189 @default.
- W2969893755 hasConcept C204787440 @default.
- W2969893755 hasConcept C27081682 @default.
- W2969893755 hasConcept C2779252780 @default.
- W2969893755 hasConcept C2780820201 @default.
- W2969893755 hasConcept C2991744798 @default.
- W2969893755 hasConcept C42219234 @default.
- W2969893755 hasConcept C535046627 @default.
- W2969893755 hasConcept C71924100 @default.
- W2969893755 hasConcept C90924648 @default.
- W2969893755 hasConceptScore W2969893755C126322002 @default.
- W2969893755 hasConceptScore W2969893755C142724271 @default.
- W2969893755 hasConceptScore W2969893755C168563851 @default.
- W2969893755 hasConceptScore W2969893755C202061045 @default.
- W2969893755 hasConceptScore W2969893755C204243189 @default.
- W2969893755 hasConceptScore W2969893755C204787440 @default.
- W2969893755 hasConceptScore W2969893755C27081682 @default.
- W2969893755 hasConceptScore W2969893755C2779252780 @default.
- W2969893755 hasConceptScore W2969893755C2780820201 @default.
- W2969893755 hasConceptScore W2969893755C2991744798 @default.
- W2969893755 hasConceptScore W2969893755C42219234 @default.
- W2969893755 hasConceptScore W2969893755C535046627 @default.
- W2969893755 hasConceptScore W2969893755C71924100 @default.
- W2969893755 hasConceptScore W2969893755C90924648 @default.
- W2969893755 hasIssue "3" @default.
- W2969893755 hasLocation W29698937551 @default.
- W2969893755 hasOpenAccess W2969893755 @default.
- W2969893755 hasPrimaryLocation W29698937551 @default.
- W2969893755 hasRelatedWork W2039865683 @default.
- W2969893755 hasRelatedWork W2056697517 @default.
- W2969893755 hasRelatedWork W2061892122 @default.
- W2969893755 hasRelatedWork W2138201488 @default.
- W2969893755 hasRelatedWork W2158273200 @default.
- W2969893755 hasRelatedWork W2366120589 @default.
- W2969893755 hasRelatedWork W2390346626 @default.
- W2969893755 hasRelatedWork W2597834390 @default.
- W2969893755 hasRelatedWork W2605932883 @default.
- W2969893755 hasRelatedWork W2913074078 @default.
- W2969893755 hasVolume "29" @default.
- W2969893755 isParatext "false" @default.
- W2969893755 isRetracted "false" @default.
- W2969893755 magId "2969893755" @default.
- W2969893755 workType "article" @default.