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• W2969894923 endingPage "1274" @default.
• W2969894923 startingPage "1265" @default.
• W2969894923 abstract "Abstract Here, we show that heart rate in zebrafish Danio rerio is dependent upon two pacemaking mechanisms and it possesses a limited ability to reset the cardiac pacemaker with temperature acclimation. Electrocardiogram recordings, taken from individual, anaesthetised zebrafish that had been acclimated to 18, 23 or 28°C were used to follow the response of maximum heart rate ( f Hmax ) to acute warming from 18°C until signs of cardiac failure appeared (up to c . 40°C). Because f Hmax was similar across the acclimation groups at almost all equivalent test temperatures, warm acclimation was limited to one significant effect, the 23°C acclimated zebrafish had a significantly higher (21%) peak f Hmax and reached a higher (3°C) test temperature than the 18°C acclimated zebrafish. Using zatebradine to block the membrane hyperpolarisation‐activated cyclic nucleotide–gated channels (HCN) and examine the contribution of the membrane clock mechanisms to cardiac pacemaking, f Hmax was significantly reduced (by at least 40%) at all acute test temperatures and significantly more so at most test temperatures for zebrafish acclimated to 28°C vs . 23°C. Thus, HCN channels and the membrane clock were not only important, but could be modified by thermal acclimation. Using a combination of ryanodine (to block sarcoplasmic calcium release) and thapsigargin (to block sarcoplasmic calcium reuptake) to examine the contribution of sarcoplasmic reticular handling of calcium and the calcium clock, f Hmax was again consistently reduced independent of the test temperature and acclimation temperature, but to a significantly lesser degree than zatebradine for zebrafish acclimated to both 28 and 18°C. Thus, the calcium clock mechanism plays an additional role in setting pacemaker activity that was independent of temperature. In conclusion, the zebrafish cardiac pacemaker has a limited temperature acclimation ability compared with known effects for other fishes and involves two pacemaking mechanisms, one of which was independent of temperature." @default.
• W2969894923 created "2019-08-29" @default.
• W2969894923 creator A5087624247 @default.
• W2969894923 creator A5091823728 @default.
• W2969894923 date "2019-10-21" @default.
• W2969894923 modified "2023-09-30" @default.
• W2969894923 title "Membrane and calcium clock mechanisms contribute variably as a function of temperature to setting cardiac pacemaker rate in zebrafish<i>Danio rerio</i>" @default.
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• W2969894923 doi "https://doi.org/10.1111/jfb.14126" @default.
• W2969894923 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31429079" @default.
• W2969894923 hasPublicationYear "2019" @default.
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