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• W2969895713 abstract "<b><i>Background/Aims:</i></b> We aimed to investigate the effects of glomerular IgM and C3 deposition on outcomes of adult patients with primary focal segmental glomerulosclerosis (FSGS). <b><i>Methods:</i></b> In this retrospective analysis, 86 consecutive adult patients with biopsy-proven primary FSGS were stratified into 3 groups according to their histopathological features: IgM– C3–, IgM+ C3–, and IgM+ C3+. Primary outcome was defined as at least a 50% reduction in baseline estimated glomerular filtration rate (eGFR) or development of kidney failure, while complete or partial remission rates were secondary outcomes. <b><i>Results:</i></b> Glomerular IgM deposits were found in 44 (51.1%) patients, 22 (25.5%) of which presented with accompanying C3 deposition. Patients in IgM+ C3+ group had higher level of proteinuria (5.6 g/24 h [3.77–8.5], <i>p</i> = 0.073), higher percentage of segmental glomerulosclerosis (20% [12.3–27.2], <i>p</i> = 0.001), and lower levels of eGFR (69 ± 37.2 mL/min/1.73 m², <i>p</i> = 0.029) and serum albumin (2.71 ± 0.85 g/dL, <i>p</i> = 0.045) at the time of diagnosis. Despite 86.3% of patients in IgM+ C3+ group (19/22) received immunosuppressive treatment, the primary outcome was more common in patients in the IgM+ C3+ group compared with patients in IgM+ C3– and IgM– C3– groups (11 [50%] vs. 2 [9%] and 11 [26.1%] respectively [<i>p</i> = 0.010]). Complete or partial remission rates were lower in patients in the IgM+ C3+ group (5/22, 22.7%), as well (<i>p</i> = 0.043). Multivariate Cox regression analysis revealed that IgM and C3 co-deposition was an independent risk factor associated with primary outcome (hazard ratio 3.355, 95% CI 1.349–8.344, <i>p</i> = 0.009). <b><i>Conclusions:</i></b> Glomerular IgM and C3 co-deposition is a predictor of unfavorable renal outcomes in adult patients with primary FSGS." @default.
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• W2969895713 date "2019-01-01" @default.
• W2969895713 modified "2023-09-26" @default.
• W2969895713 title "Co-Deposition of IgM and C3 May Indicate Unfavorable Renal Outcomes in Adult Patients with Primary Focal Segmental Glomerulosclerosis" @default.
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• W2969895713 doi "https://doi.org/10.1159/000501827" @default.
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