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- W2969897975 abstract "Poly(ε-caprolactone) (PCL) is a bioresorbable synthetic polyester with numerous biomedical applications. PCL membranes show great potential in guided tissue regeneration because they are biocompatible, occlusive and space maintaining, but lack osteoconductivity. Therefore, two different types of mesoporous bioactive glasses (SiO2-CaO-P2O5 and SiO2-SrO-P2O5) were synthesized and incorporated in PCL thin membranes by spin coating. To enhance the osteogenic effect of resulting membranes, the bioglasses were loaded with the bisphosphonate drug ibandronate prior to their incorporation in the polymeric matrix. The effect of the composition of the bioglasses as well as the presence of absorbed ibandronate on the physicochemical, cell attachment and differentiation properties of the PCL membranes was evaluated. Both fillers led to a decrease of the crystallinity of PCL, along with an increase in its hydrophilicity and a noticeable increase in its bioactivity. Bioactivity was further increased in the presence of a Sr substituted bioglass loaded with ibandronate. The membranes exhibited excellent biocompatibility upon estimation of their cytotoxicity on Wharton's Jelly Mesenchymal Stromal Cells (WJ-SCs), while they presented higher osteogenic potential in comparison with neat PCL after WJ-SCs induced differentiation towards bone cells, which was enhanced by a possible synergistic effect of Sr and ibandronate." @default.
- W2969897975 created "2019-08-29" @default.
- W2969897975 creator A5013269628 @default.
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- W2969897975 creator A5029519781 @default.
- W2969897975 creator A5036587968 @default.
- W2969897975 creator A5089208139 @default.
- W2969897975 date "2019-08-23" @default.
- W2969897975 modified "2023-10-12" @default.
- W2969897975 title "Composite Membranes of Poly(ε-caprolactone) with Bisphosphonate-Loaded Bioactive Glasses for Potential Bone Tissue Engineering Applications" @default.
- W2969897975 cites W1569310614 @default.
- W2969897975 cites W1844048390 @default.
- W2969897975 cites W1883141367 @default.
- W2969897975 cites W1967000850 @default.
- W2969897975 cites W1967995141 @default.
- W2969897975 cites W1971139062 @default.
- W2969897975 cites W1974934907 @default.
- W2969897975 cites W1977942007 @default.
- W2969897975 cites W1978393630 @default.
- W2969897975 cites W1979918880 @default.
- W2969897975 cites W1982414211 @default.
- W2969897975 cites W1983559420 @default.
- W2969897975 cites W1987411261 @default.
- W2969897975 cites W1987546158 @default.
- W2969897975 cites W1987742563 @default.
- W2969897975 cites W1989510343 @default.
- W2969897975 cites W1992757248 @default.
- W2969897975 cites W1996898338 @default.
- W2969897975 cites W2002395215 @default.
- W2969897975 cites W2002824014 @default.
- W2969897975 cites W2004237708 @default.
- W2969897975 cites W2010190869 @default.
- W2969897975 cites W2010395830 @default.
- W2969897975 cites W2012632030 @default.
- W2969897975 cites W2017066441 @default.
- W2969897975 cites W2017701542 @default.
- W2969897975 cites W2018169465 @default.
- W2969897975 cites W2019858187 @default.
- W2969897975 cites W2020084394 @default.
- W2969897975 cites W2020344312 @default.
- W2969897975 cites W2020406782 @default.
- W2969897975 cites W2025180353 @default.
- W2969897975 cites W2030422796 @default.
- W2969897975 cites W2032853317 @default.
- W2969897975 cites W2033643244 @default.
- W2969897975 cites W2034377800 @default.
- W2969897975 cites W2035763682 @default.
- W2969897975 cites W2037186348 @default.
- W2969897975 cites W2037621107 @default.
- W2969897975 cites W2039484137 @default.
- W2969897975 cites W2041571480 @default.
- W2969897975 cites W2051343855 @default.
- W2969897975 cites W2053172990 @default.
- W2969897975 cites W2056320818 @default.
- W2969897975 cites W2058122340 @default.
- W2969897975 cites W2062410758 @default.
- W2969897975 cites W2063857099 @default.
- W2969897975 cites W2067595293 @default.
- W2969897975 cites W2070071981 @default.
- W2969897975 cites W2075755484 @default.
- W2969897975 cites W2077786188 @default.
- W2969897975 cites W2080921228 @default.
- W2969897975 cites W2082478581 @default.
- W2969897975 cites W2083331996 @default.
- W2969897975 cites W2086699454 @default.
- W2969897975 cites W2089354821 @default.
- W2969897975 cites W2089480064 @default.
- W2969897975 cites W2091415490 @default.
- W2969897975 cites W2091823030 @default.
- W2969897975 cites W2092869936 @default.
- W2969897975 cites W2094630394 @default.
- W2969897975 cites W2095191638 @default.
- W2969897975 cites W2098904414 @default.
- W2969897975 cites W2108834310 @default.
- W2969897975 cites W2115011664 @default.
- W2969897975 cites W2117894560 @default.
- W2969897975 cites W2121605256 @default.
- W2969897975 cites W2124700095 @default.
- W2969897975 cites W2135157677 @default.
- W2969897975 cites W2141342354 @default.
- W2969897975 cites W2144208840 @default.
- W2969897975 cites W2149162884 @default.
- W2969897975 cites W2157951056 @default.
- W2969897975 cites W2169487802 @default.
- W2969897975 cites W2170525031 @default.
- W2969897975 cites W2172637282 @default.
- W2969897975 cites W2189293761 @default.
- W2969897975 cites W2193745084 @default.
- W2969897975 cites W2253918471 @default.
- W2969897975 cites W2275458638 @default.
- W2969897975 cites W2293659353 @default.
- W2969897975 cites W2326326484 @default.
- W2969897975 cites W2347073348 @default.
- W2969897975 cites W2414408356 @default.
- W2969897975 cites W2416877185 @default.
- W2969897975 cites W2436920021 @default.