FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2969899249> ?p ?o ?g. }

• W2969899249 endingPage "102693" @default.
• W2969899249 startingPage "102693" @default.
• W2969899249 abstract "DNA replication, the faithful copying of genetic material, must be tightly regulated to produce daughter cells with intact copies of the chromosome(s). This regulated replication is initiated by binding of specific proteins at replication origins, such as DnaA to oriC in bacteria. However, unregulated replication can sometimes be initiated at other sites, which can threaten genomic stability. One of the first systems of unregulated replication to be described is the one activated in Escherichia coli mutants lacking RNase HI (rnhA). In fact, rnhA mutants can replicate their chromosomes in a DnaA- and oriC-independent process. Because this replication occurs in cells lacking RNase HI, it is proposed that RNA from R-loops is used as a DNA polymerase primer. Replication from R-loops has recently attracted increased attention due to the advent of DNA:RNA hybrid immunoprecipitation coupled with high-throughput DNA sequencing that revealed the high prevalence of R-loop formation in many organisms, and the demonstration that R-loops can severely threaten genomic stability. Although R-loops have been linked to genomic instability mostly via replication stress, evidence of their toxic effects via unregulated replication has also been presented. Replication from R-loops may also beneficially trigger stress-induced mutagenesis (SIM) that assists bacterial adaptation to stress. Here, we describe the cis- and trans-acting elements involved in R-loop-dependent replication in bacteria, with an emphasis on new data obtained with type 1A topoisomerase mutants and new available technologies. Furthermore, we discuss about the mechanism(s) by which R-loops can reshape the genome with both negative and positive outcomes." @default.
• W2969899249 created "2019-08-29" @default.
• W2969899249 creator A5048780532 @default.
• W2969899249 creator A5054267189 @default.
• W2969899249 date "2019-12-01" @default.
• W2969899249 modified "2023-10-04" @default.
• W2969899249 title "R-loop-dependent replication and genomic instability in bacteria" @default.
• W2969899249 cites W1493470226 @default.
• W2969899249 cites W1501390905 @default.
• W2969899249 cites W1507138933 @default.
• W2969899249 cites W1527634644 @default.
• W2969899249 cites W1542151197 @default.
• W2969899249 cites W1579465735 @default.
• W2969899249 cites W1601725607 @default.
• W2969899249 cites W1603679608 @default.
• W2969899249 cites W1624476691 @default.
• W2969899249 cites W1771679097 @default.
• W2969899249 cites W1788706436 @default.
• W2969899249 cites W1823881050 @default.
• W2969899249 cites W1893811411 @default.
• W2969899249 cites W1963782006 @default.
• W2969899249 cites W1967706132 @default.
• W2969899249 cites W1968288171 @default.
• W2969899249 cites W1970966311 @default.
• W2969899249 cites W1971203189 @default.
• W2969899249 cites W1972067801 @default.
• W2969899249 cites W1980357487 @default.
• W2969899249 cites W1981844387 @default.
• W2969899249 cites W1984592234 @default.
• W2969899249 cites W1987024381 @default.
• W2969899249 cites W1988621347 @default.
• W2969899249 cites W1990308467 @default.
• W2969899249 cites W1994256332 @default.
• W2969899249 cites W1997877627 @default.
• W2969899249 cites W1998706983 @default.
• W2969899249 cites W1999718691 @default.
• W2969899249 cites W1999967568 @default.
• W2969899249 cites W2006259275 @default.
• W2969899249 cites W2015818551 @default.
• W2969899249 cites W2022733429 @default.
• W2969899249 cites W2023528995 @default.
• W2969899249 cites W2028198542 @default.
• W2969899249 cites W2033011135 @default.
• W2969899249 cites W2034973272 @default.
• W2969899249 cites W2039751418 @default.
• W2969899249 cites W2041214497 @default.
• W2969899249 cites W2048100858 @default.
• W2969899249 cites W2049986460 @default.
• W2969899249 cites W2054197881 @default.
• W2969899249 cites W2056166556 @default.
• W2969899249 cites W2057242202 @default.
• W2969899249 cites W2060259299 @default.
• W2969899249 cites W2078969662 @default.
• W2969899249 cites W2082995057 @default.
• W2969899249 cites W2083893624 @default.
• W2969899249 cites W2084717400 @default.
• W2969899249 cites W2084728529 @default.
• W2969899249 cites W2101685360 @default.
• W2969899249 cites W2113955753 @default.
• W2969899249 cites W2128485064 @default.
• W2969899249 cites W2131224273 @default.
• W2969899249 cites W2138917122 @default.
• W2969899249 cites W2143157366 @default.
• W2969899249 cites W2144463188 @default.
• W2969899249 cites W2144657744 @default.
• W2969899249 cites W2146994562 @default.
• W2969899249 cites W2149359491 @default.
• W2969899249 cites W2149691257 @default.
• W2969899249 cites W2155850414 @default.
• W2969899249 cites W2160131663 @default.
• W2969899249 cites W2165529204 @default.
• W2969899249 cites W2169119507 @default.
• W2969899249 cites W2185659123 @default.
• W2969899249 cites W2199968103 @default.
• W2969899249 cites W2277665616 @default.
• W2969899249 cites W2312515828 @default.
• W2969899249 cites W2340421620 @default.
• W2969899249 cites W2409349875 @default.
• W2969899249 cites W2414700431 @default.
• W2969899249 cites W2415584939 @default.
• W2969899249 cites W2423627688 @default.
• W2969899249 cites W2567065862 @default.
• W2969899249 cites W2742880086 @default.
• W2969899249 cites W2749177415 @default.
• W2969899249 cites W2769357315 @default.
• W2969899249 cites W2769842748 @default.
• W2969899249 cites W2802607766 @default.
• W2969899249 cites W2806684614 @default.
• W2969899249 cites W2807924995 @default.
• W2969899249 cites W2810632592 @default.
• W2969899249 cites W2811245672 @default.
• W2969899249 cites W2885156893 @default.
• W2969899249 cites W2891611582 @default.
• W2969899249 cites W2909756811 @default.
• W2969899249 cites W2913346540 @default.
• W2969899249 cites W2915622130 @default.
• W2969899249 cites W2923222362 @default.
• W2969899249 cites W2933222148 @default.

• next