FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2969923389> ?p ?o ?g. }

• W2969923389 endingPage "274" @default.
• W2969923389 startingPage "274" @default.
• W2969923389 abstract "Pharmacognosy Magazine ,2019,15,64,274-279.DOI:10.4103/pm.pm_4_19Published:August 2019Type:Original Article Authors:Takkella Nagamma, Anjaneyulu Konuri, Rajalekshmi Maheshwari, EG Padmanabha Udupa, and Yogendra Nayak Author(s) affiliations:Takkella Nagamma1, Anjaneyulu Konuri2, Rajalekshmi Maheshwari3, EG Padmanabha Udupa4, Yogendra Nayak5 1Department of Biochemistry, Melaka Manipal Medical College (Manipal Campus), Manipal Academy of Higher Education, Manipal, Karnataka, India 2Department of Anatomy, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India 3Department of Pharmacognosy, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, India 4Department of Biochemistry, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India 5Department of Pharmacology, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, India Abstract:Objectives: This study was to standardize Trigonella foenum-graecum (fenugreek, TFG) seed extract by high-performance thin-layer chromatography (HPTLC) and to test its efficacy in ovariectomy-induced hyperlipidemia in rats. Materials and Methods: Hydroalcoholic extract of TFG-seed was standardized by HPTLC using diosgenin as standard. Female rats were selected and bilateral-ovariectomy was performed. Rats in Group-1 and Group-2 were healthy control and Ovariectomized (OVX) respectively. After 14-days of ovariectomy, Group 3 and Group 4 rats were administered TFG-extract (200 mg/kg/day) and 17β-estradiol (100 μg/kg/day), respectively, for 30 days. Serum lipid profile and liver oxidative markers were determined to compare between the groups. Results: The phytoestrogen, diosgenin, was found to be 0.83% w/w in the TFG-seed extract. The OVX rats exhibited a significant increase (P < 0.001) in serum cholesterol, triglycerides, low-density lipoprotein, and decreased high-density lipoprotein compared to control rats. The significant increase in thiobarbituric acid reactive substances and decreased glutathione was the indication of oxidative stress in the liver of OVX rats. Treatment with TFG extract significantly reverted these parameters in OVX rats which was comparable to that of standard 17β-estradiol. Conclusion: The favorable effect of TFG extract on ovariectomy-induced hyperlipidemia could be because of diosgenin along with other flavonoids and phenols in it. Thus, TFG has the benefits in menopause-induced hyperlipidemia and oxidative stress. Keywords:histopathology, lipid profile, menopause, oxidative stress, Phytoestrogens, Trigonella foenum-graecumView:PDF (1.46 MB)" @default.
• W2969923389 created "2019-08-29" @default.
• W2969923389 creator A5000097762 @default.
• W2969923389 creator A5023500323 @default.
• W2969923389 creator A5038891433 @default.
• W2969923389 creator A5045461648 @default.
• W2969923389 creator A5060830462 @default.
• W2969923389 date "2019-01-01" @default.
• W2969923389 modified "2023-10-01" @default.
• W2969923389 title "Efficacy of Trigonella foenum-graecum seed extract on ovariectomy-induced hyperlipidemia, oxidative stress, and histopathological changes in rats" @default.
• W2969923389 cites W1966701899 @default.
• W2969923389 cites W1994306577 @default.
• W2969923389 cites W1997129280 @default.
• W2969923389 cites W2016945066 @default.
• W2969923389 cites W2019978470 @default.
• W2969923389 cites W2022727635 @default.
• W2969923389 cites W2034925497 @default.
• W2969923389 cites W2045888895 @default.
• W2969923389 cites W2049485716 @default.
• W2969923389 cites W2052823357 @default.
• W2969923389 cites W2072442840 @default.
• W2969923389 cites W2088071559 @default.
• W2969923389 cites W2113264115 @default.
• W2969923389 cites W2116404316 @default.
• W2969923389 cites W2119641064 @default.
• W2969923389 cites W2121483707 @default.
• W2969923389 cites W2132443242 @default.
• W2969923389 cites W2138086981 @default.
• W2969923389 cites W2139272277 @default.
• W2969923389 cites W2140184937 @default.
• W2969923389 cites W2175706547 @default.
• W2969923389 cites W2606232634 @default.
• W2969923389 cites W4233082628 @default.
• W2969923389 cites W4236205599 @default.
• W2969923389 cites W4246670197 @default.
• W2969923389 cites W4254707915 @default.
• W2969923389 cites W976844117 @default.
• W2969923389 doi "https://doi.org/10.4103/pm.pm_4_19" @default.
• W2969923389 hasPublicationYear "2019" @default.
• W2969923389 type Work @default.
• W2969923389 sameAs 2969923389 @default.
• W2969923389 citedByCount "4" @default.
• W2969923389 countsByYear W29699233892021 @default.
• W2969923389 countsByYear W29699233892022 @default.
• W2969923389 countsByYear W29699233892023 @default.
• W2969923389 crossrefType "journal-article" @default.
• W2969923389 hasAuthorship W2969923389A5000097762 @default.
• W2969923389 hasAuthorship W2969923389A5023500323 @default.
• W2969923389 hasAuthorship W2969923389A5038891433 @default.
• W2969923389 hasAuthorship W2969923389A5045461648 @default.
• W2969923389 hasAuthorship W2969923389A5060830462 @default.
• W2969923389 hasConcept C126322002 @default.
• W2969923389 hasConcept C2776601336 @default.
• W2969923389 hasConcept C2778163477 @default.
• W2969923389 hasConcept C2778270857 @default.
• W2969923389 hasConcept C2778753648 @default.
• W2969923389 hasConcept C42972112 @default.
• W2969923389 hasConcept C54355233 @default.
• W2969923389 hasConcept C556039675 @default.
• W2969923389 hasConcept C71924100 @default.
• W2969923389 hasConcept C86803240 @default.
• W2969923389 hasConcept C98274493 @default.
• W2969923389 hasConceptScore W2969923389C126322002 @default.
• W2969923389 hasConceptScore W2969923389C2776601336 @default.
• W2969923389 hasConceptScore W2969923389C2778163477 @default.
• W2969923389 hasConceptScore W2969923389C2778270857 @default.
• W2969923389 hasConceptScore W2969923389C2778753648 @default.
• W2969923389 hasConceptScore W2969923389C42972112 @default.
• W2969923389 hasConceptScore W2969923389C54355233 @default.
• W2969923389 hasConceptScore W2969923389C556039675 @default.
• W2969923389 hasConceptScore W2969923389C71924100 @default.
• W2969923389 hasConceptScore W2969923389C86803240 @default.
• W2969923389 hasConceptScore W2969923389C98274493 @default.
• W2969923389 hasIssue "64" @default.
• W2969923389 hasLocation W29699233891 @default.
• W2969923389 hasOpenAccess W2969923389 @default.
• W2969923389 hasPrimaryLocation W29699233891 @default.
• W2969923389 hasRelatedWork W2056905642 @default.
• W2969923389 hasRelatedWork W2092193834 @default.
• W2969923389 hasRelatedWork W2116328028 @default.
• W2969923389 hasRelatedWork W2136985187 @default.
• W2969923389 hasRelatedWork W2360962996 @default.
• W2969923389 hasRelatedWork W2756973366 @default.
• W2969923389 hasRelatedWork W2795849888 @default.
• W2969923389 hasRelatedWork W2899025251 @default.
• W2969923389 hasRelatedWork W2904756024 @default.
• W2969923389 hasRelatedWork W3214903362 @default.
• W2969923389 hasVolume "15" @default.
• W2969923389 isParatext "false" @default.
• W2969923389 isRetracted "false" @default.
• W2969923389 magId "2969923389" @default.
• W2969923389 workType "article" @default.