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• W2969979209 abstract "UK law permits parents to use mitochondrial replacement (MR) to have genetically-related children without serious mitochondrial disease. However, long-term follow-up is required for each case. Whether this follow-up should be left to physicians, parents, or offspring has not been established. Due to the experimental status of MR, physicians must inform parents of the risks and the importance of follow-up tailored to a specific mitochondrial disease. Given that the use of MR is a responsible exercise of reproductive freedom, parents should ensure that the follow-up is performed properly and in the best interests of their offspring. On becoming legally competent, the resulting children should be entitled to refuse follow-up provided that the prevention of mitochondrial disease with no adverse effects has been evident till then. This offspring-centred long-term follow-up approach might also be applied to the use of MR for infertility treatment, even though the primary endpoint is healthy live births." @default.
• W2969979209 created "2019-08-29" @default.
• W2969979209 creator A5039275700 @default.
• W2969979209 date "2019-08-20" @default.
• W2969979209 modified "2023-09-27" @default.
• W2969979209 title "Should Long-Term Follow-up Post-Mitochondrial Replacement be Left up to Physicians, Parents, or Offspring?" @default.
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• W2969979209 doi "https://doi.org/10.1080/20502877.2019.1654672" @default.
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