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• W2969983325 endingPage "1660" @default.
• W2969983325 startingPage "1649" @default.
• W2969983325 abstract "Different neuromodulators rarely act independent from each other to modify neural processes but are instead coreleased, gated, or modulated. To understand this interdependence of neuromodulators and their collective influence on local circuits during different brain states, it is necessary to reliably extract local concentrations of multiple neuromodulators in vivo. Here we describe results using solid-phase microextraction (SPME), a method providing sensitive, multineuromodulator measurements. SPME is a sampling method that is coupled with mass spectrometry to quantify collected analytes. Reliable measurements of glutamate, dopamine, acetylcholine, and choline were made simultaneously within frontal cortex and striatum of two macaque monkeys (Macaca mulatta) during goal-directed behavior. We find glutamate concentrations several orders of magnitude higher than acetylcholine and dopamine in all brain regions. Dopamine was reliably detected in the striatum at tenfold higher concentrations than acetylcholine. Acetylcholine and choline concentrations were detected with high consistency across brain areas within monkeys and between monkeys. These findings illustrate that SPME microprobes provide a versatile novel tool to characterize multiple neuromodulators across different brain areas in vivo to understand the interdependence and covariation of neuromodulators during goal-directed behavior. Such data would be important to better distinguish between different behavioral states and characterize dysfunctional brain states that may be evident in psychiatric disorders.NEW & NOTEWORTHY Our paper reports a reliable and sensitive novel method for measuring the absolute concentrations of glutamate, acetylcholine, choline, dopamine, and serotonin in brain circuits in vivo. We show that this method reliably samples multiple neurochemicals in three brain areas simultaneously while nonhuman primates are engaged in goal-directed behavior. We further describe how the methodology we describe here may be used by electrophysiologists as a low-barrier-to-entry tool for measuring multiple neurochemicals." @default.
• W2969983325 created "2019-08-29" @default.
• W2969983325 creator A5020165662 @default.
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• W2969983325 creator A5061144141 @default.
• W2969983325 creator A5086231119 @default.
• W2969983325 date "2019-10-01" @default.
• W2969983325 modified "2023-09-26" @default.
• W2969983325 title "Multineuromodulator measurements across fronto-striatal network areas of the behaving macaque using solid-phase microextraction" @default.
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• W2969983325 doi "https://doi.org/10.1152/jn.00321.2019" @default.
• W2969983325 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6843094" @default.
• W2969983325 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31433731" @default.
• W2969983325 hasPublicationYear "2019" @default.
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