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• W2970005728 endingPage "801" @default.
• W2970005728 startingPage "792" @default.
• W2970005728 abstract "Much structural information has been amassed on ATP-binding cassette (ABC) transporters, including hundreds of structures of isolated domains and an increasing array of full-length transporters. The structures capture different steps in the transport cycle and have aided in the design and interpretation of computational simulations and biophysics experiments. These data provide a maturing, although still incomplete, elucidation of the protein dynamics and mechanisms of substrate selection and transit through the transporters. We present an updated view of the classical alternating-access mechanism as it applies to eukaryotic ABC transporters, focusing on type I exporters. Our model helps frame the progress in, and remaining questions about, transporter energetics, how substrates are selected and how ATP is consumed to perform work at the molecular scale. Many human ABC transporters are associated with disease; we highlight progress in understanding their pharmacology through the lens of structural biology and describe how this knowledge suggests approaches to pharmacologically targeting these transporters." @default.
• W2970005728 created "2019-09-05" @default.
• W2970005728 creator A5078386611 @default.
• W2970005728 creator A5079526241 @default.
• W2970005728 date "2019-08-26" @default.
• W2970005728 modified "2023-10-02" @default.
• W2970005728 title "Mechanics and pharmacology of substrate selection and transport by eukaryotic ABC exporters" @default.
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