FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2970007337> ?p ?o ?g. }

• W2970007337 abstract "Muscle loss is a debilitating side effect to prostate cancer (PCa) experienced by nearly 60% of men. The purpose of this study was to test the hypothesis that Nexrutine® , a bark extract from the Phellodendrum amurense, can protect against prostate cancer induced muscle loss in a similar manner as exercise, using the transgenic adenocarcinoma of mouse prostate (TRAMP) model. Forty-five, 8- to 10-week old TRAMP mice were randomized to either control, Nexrutine® (600 mg/kg pelleted in chow) or exercise (voluntary wheel running). Mice were serially sacrificed at weeks 4, 8, 12, and 20, at which time either the left or right gastrocnemius muscle was harvested, weighted, and frozen. Proteolysis inducing factor (PIF), ubiquitin, and NF-κB concentrations were quantified using ELISA kits. Nexrutine® and exercise were equally able to protect TRAMP mice against PCa-induced muscle loss (P = 0.04). Both interventions decreased intramuscular PIF concentrations at 20 weeks compared to control (P < 0.05). A treatment effect was also observed when all time points were combined with exercise significantly lowering PIF concentrations (P < 0.01). Exercise significantly lowered intramuscular ubiquitin concentrations in weeks 4, 8, and 20 compared to control mice (P < 0.001). A treatment effect was also observed with exercise significantly lowering ubiquitin compared to control mice (P < 0.001). No significant changes were observed for NF-κB. The results of this investigation demonstrate that PCa-induced muscle loss can be attenuated with the herbal supplement Nexrutine® . This investigation provides preliminary evidence to support continued research into Nexrutine® as a potential exercise analog in protecting against muscle loss." @default.
• W2970007337 created "2019-09-05" @default.
• W2970007337 creator A5000043199 @default.
• W2970007337 creator A5031311039 @default.
• W2970007337 creator A5034471398 @default.
• W2970007337 creator A5052219741 @default.
• W2970007337 creator A5062916879 @default.
• W2970007337 creator A5070882473 @default.
• W2970007337 creator A5085773356 @default.
• W2970007337 date "2019-08-01" @default.
• W2970007337 modified "2023-10-14" @default.
• W2970007337 title "Nexrutine ® preserves muscle mass similar to exercise in prostate cancer mouse model" @default.
• W2970007337 cites W1535606501 @default.
• W2970007337 cites W1656747689 @default.
• W2970007337 cites W1779691448 @default.
• W2970007337 cites W1865608113 @default.
• W2970007337 cites W1910033896 @default.
• W2970007337 cites W1964166589 @default.
• W2970007337 cites W1965860042 @default.
• W2970007337 cites W1972744591 @default.
• W2970007337 cites W1983660080 @default.
• W2970007337 cites W1985044219 @default.
• W2970007337 cites W1990869186 @default.
• W2970007337 cites W2004830125 @default.
• W2970007337 cites W2008869575 @default.
• W2970007337 cites W2011567765 @default.
• W2970007337 cites W2031529249 @default.
• W2970007337 cites W2041833819 @default.
• W2970007337 cites W2042696598 @default.
• W2970007337 cites W2046289475 @default.
• W2970007337 cites W2059980403 @default.
• W2970007337 cites W2060197761 @default.
• W2970007337 cites W2065918344 @default.
• W2970007337 cites W2073560422 @default.
• W2970007337 cites W2080869439 @default.
• W2970007337 cites W2088170980 @default.
• W2970007337 cites W2088279289 @default.
• W2970007337 cites W2090008386 @default.
• W2970007337 cites W2113617434 @default.
• W2970007337 cites W2114256596 @default.
• W2970007337 cites W2114280375 @default.
• W2970007337 cites W2118941654 @default.
• W2970007337 cites W2119777429 @default.
• W2970007337 cites W2134032880 @default.
• W2970007337 cites W2143015711 @default.
• W2970007337 cites W2144577761 @default.
• W2970007337 cites W2145325724 @default.
• W2970007337 cites W2147383407 @default.
• W2970007337 cites W2149804766 @default.
• W2970007337 cites W2150680905 @default.
• W2970007337 cites W2158993583 @default.
• W2970007337 cites W2167986733 @default.
• W2970007337 cites W2169016930 @default.
• W2970007337 cites W2171267283 @default.
• W2970007337 cites W2173990401 @default.
• W2970007337 cites W2412485824 @default.
• W2970007337 cites W2800981066 @default.
• W2970007337 cites W2887052858 @default.
• W2970007337 cites W2923843444 @default.
• W2970007337 cites W2970007337 @default.
• W2970007337 cites W4318610544 @default.
• W2970007337 cites W83975188 @default.
• W2970007337 doi "https://doi.org/10.14814/phy2.14217" @default.
• W2970007337 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6712237" @default.
• W2970007337 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31456341" @default.
• W2970007337 hasPublicationYear "2019" @default.
• W2970007337 type Work @default.
• W2970007337 sameAs 2970007337 @default.
• W2970007337 citedByCount "3" @default.
• W2970007337 countsByYear W29700073372019 @default.
• W2970007337 countsByYear W29700073372021 @default.
• W2970007337 crossrefType "journal-article" @default.
• W2970007337 hasAuthorship W2970007337A5000043199 @default.
• W2970007337 hasAuthorship W2970007337A5031311039 @default.
• W2970007337 hasAuthorship W2970007337A5034471398 @default.
• W2970007337 hasAuthorship W2970007337A5052219741 @default.
• W2970007337 hasAuthorship W2970007337A5062916879 @default.
• W2970007337 hasAuthorship W2970007337A5070882473 @default.
• W2970007337 hasAuthorship W2970007337A5085773356 @default.
• W2970007337 hasBestOaLocation W29700073372 @default.
• W2970007337 hasConcept C102230213 @default.
• W2970007337 hasConcept C104317684 @default.
• W2970007337 hasConcept C121608353 @default.
• W2970007337 hasConcept C126322002 @default.
• W2970007337 hasConcept C126894567 @default.
• W2970007337 hasConcept C134018914 @default.
• W2970007337 hasConcept C141035611 @default.
• W2970007337 hasConcept C185592680 @default.
• W2970007337 hasConcept C25602115 @default.
• W2970007337 hasConcept C2775872116 @default.
• W2970007337 hasConcept C2776235491 @default.
• W2970007337 hasConcept C2779959927 @default.
• W2970007337 hasConcept C2780192828 @default.
• W2970007337 hasConcept C2780940892 @default.
• W2970007337 hasConcept C55493867 @default.
• W2970007337 hasConcept C71924100 @default.
• W2970007337 hasConceptScore W2970007337C102230213 @default.
• W2970007337 hasConceptScore W2970007337C104317684 @default.
• W2970007337 hasConceptScore W2970007337C121608353 @default.
• W2970007337 hasConceptScore W2970007337C126322002 @default.

• next