FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2970012944> ?p ?o ?g. }

• W2970012944 endingPage "10" @default.
• W2970012944 startingPage "4" @default.
• W2970012944 abstract "Abstract Objective In the mouse model, manipulations of assisted reproductive technology (ART) can lead to enlarged placentas and influence the expression of glucose transporters (GLUTs) in placentas during mid-to late-gestation. Expression of imprinted genes which plays a vital role in placental growth and function, is also vulnerable to be affected by ART. However, it is uncertain whether those abnormal changes presented in ART mouse placentas also occur in human ART placentas. Methods We compared the expression of GLUT family genes (SLC2A1- SLC2A13), mTOR activity, the expression of four imprinted genes (H19, IGF2, CDKN1C and PHLDA2), and KCNQ1OT1 methylation in human placentas conceived naturally or by ART. Results Our data showed that the placental weight and birthweight were similar between NC (n = 20) and ART group (n = 20). We found that up-regulated mRNA expression of GLUTs and elevated GLUT1 protein level occurred in human ART placentas with unchanged mTOR activity. And we found that mRNA and protein expression of PHLDA2 were significantly increased in ART placentas compared with placentas from natural pregnancies. Additionally, we revealed that ART placentas had increased expression of KCNQ1OT1 which negatively controls PHLDA2 expression. Conclusion This study reveals that the increased expression of GLUTs occurs in human ART placentas with normal mTOR activity. The down-regulated expression of imprinted gene PHLDA2 may account for the up-regulation of GLUTs. Those adaptive changes in ART placentas may explain why most of ART offspring have normal birth weight at born." @default.
• W2970012944 created "2019-09-05" @default.
• W2970012944 creator A5001087240 @default.
• W2970012944 creator A5004075481 @default.
• W2970012944 creator A5024114171 @default.
• W2970012944 creator A5034995105 @default.
• W2970012944 creator A5051868245 @default.
• W2970012944 creator A5056188108 @default.
• W2970012944 creator A5058579214 @default.
• W2970012944 creator A5058772397 @default.
• W2970012944 creator A5067221645 @default.
• W2970012944 date "2019-10-01" @default.
• W2970012944 modified "2023-10-17" @default.
• W2970012944 title "The increased expression of glucose transporters in human full-term placentas from assisted reproductive technology without changes of mTOR signaling" @default.
• W2970012944 cites W1596773911 @default.
• W2970012944 cites W1750269731 @default.
• W2970012944 cites W185183492 @default.
• W2970012944 cites W1903913120 @default.
• W2970012944 cites W1974323903 @default.
• W2970012944 cites W1977274434 @default.
• W2970012944 cites W1996431759 @default.
• W2970012944 cites W2001405008 @default.
• W2970012944 cites W2026274018 @default.
• W2970012944 cites W2027628668 @default.
• W2970012944 cites W2030167637 @default.
• W2970012944 cites W2030673833 @default.
• W2970012944 cites W2035953665 @default.
• W2970012944 cites W2040017622 @default.
• W2970012944 cites W2043668342 @default.
• W2970012944 cites W2051542118 @default.
• W2970012944 cites W2058221507 @default.
• W2970012944 cites W2058986394 @default.
• W2970012944 cites W2059387067 @default.
• W2970012944 cites W2082316365 @default.
• W2970012944 cites W2084625697 @default.
• W2970012944 cites W2097814975 @default.
• W2970012944 cites W2099560343 @default.
• W2970012944 cites W2109580184 @default.
• W2970012944 cites W2111806142 @default.
• W2970012944 cites W2114100575 @default.
• W2970012944 cites W2114570899 @default.
• W2970012944 cites W2115944887 @default.
• W2970012944 cites W2126717933 @default.
• W2970012944 cites W2127905342 @default.
• W2970012944 cites W2131017300 @default.
• W2970012944 cites W2139462280 @default.
• W2970012944 cites W2141967607 @default.
• W2970012944 cites W2162969866 @default.
• W2970012944 cites W2170028368 @default.
• W2970012944 cites W2205944324 @default.
• W2970012944 cites W2226113296 @default.
• W2970012944 cites W2254272094 @default.
• W2970012944 cites W2532859617 @default.
• W2970012944 cites W2623412402 @default.
• W2970012944 cites W2626862484 @default.
• W2970012944 cites W2770637676 @default.
• W2970012944 cites W2771498566 @default.
• W2970012944 cites W2787931223 @default.
• W2970012944 cites W2792448726 @default.
• W2970012944 cites W2901283446 @default.
• W2970012944 doi "https://doi.org/10.1016/j.placenta.2019.08.087" @default.
• W2970012944 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31491693" @default.
• W2970012944 hasPublicationYear "2019" @default.
• W2970012944 type Work @default.
• W2970012944 sameAs 2970012944 @default.
• W2970012944 citedByCount "10" @default.
• W2970012944 countsByYear W29700129442021 @default.
• W2970012944 countsByYear W29700129442022 @default.
• W2970012944 crossrefType "journal-article" @default.
• W2970012944 hasAuthorship W2970012944A5001087240 @default.
• W2970012944 hasAuthorship W2970012944A5004075481 @default.
• W2970012944 hasAuthorship W2970012944A5024114171 @default.
• W2970012944 hasAuthorship W2970012944A5034995105 @default.
• W2970012944 hasAuthorship W2970012944A5051868245 @default.
• W2970012944 hasAuthorship W2970012944A5056188108 @default.
• W2970012944 hasAuthorship W2970012944A5058579214 @default.
• W2970012944 hasAuthorship W2970012944A5058772397 @default.
• W2970012944 hasAuthorship W2970012944A5067221645 @default.
• W2970012944 hasConcept C121332964 @default.
• W2970012944 hasConcept C126322002 @default.
• W2970012944 hasConcept C134018914 @default.
• W2970012944 hasConcept C161573976 @default.
• W2970012944 hasConcept C16685009 @default.
• W2970012944 hasConcept C185592680 @default.
• W2970012944 hasConcept C2779306644 @default.
• W2970012944 hasConcept C61797465 @default.
• W2970012944 hasConcept C62478195 @default.
• W2970012944 hasConcept C62520636 @default.
• W2970012944 hasConcept C71924100 @default.
• W2970012944 hasConcept C86554907 @default.
• W2970012944 hasConcept C86803240 @default.
• W2970012944 hasConcept C95444343 @default.
• W2970012944 hasConceptScore W2970012944C121332964 @default.
• W2970012944 hasConceptScore W2970012944C126322002 @default.
• W2970012944 hasConceptScore W2970012944C134018914 @default.
• W2970012944 hasConceptScore W2970012944C161573976 @default.
• W2970012944 hasConceptScore W2970012944C16685009 @default.
• W2970012944 hasConceptScore W2970012944C185592680 @default.

• next