FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2970018255> ?p ?o ?g. }

• W2970018255 endingPage "2462" @default.
• W2970018255 startingPage "2453" @default.
• W2970018255 abstract "Lon is a widely conserved housekeeping protease found in all domains of life. Bacterial Lon is involved in recovery from various types of stress, including tolerance to fluoroquinolone antibiotics, and is linked to pathogenesis in a number of organisms. However, detailed functional studies of Lon have been limited by the lack of selective, cell-permeant inhibitors. Here, we describe the use of positional scanning libraries of hybrid peptide substrates to profile the primary sequence specificity of bacterial Lon. In addition to identifying optimal natural amino acid binding preferences, we identified several non-natural residues that were leveraged to develop optimal peptide substrates as well as a potent peptidic boronic acid inhibitor of Lon. Treatment of Escherichia coli with this inhibitor promotes UV-induced filamentation and reduces tolerance to ciprofloxacin, phenocopying established lon-deletion phenotypes. It is also nontoxic to mammalian cells due to its selectivity for Lon over the proteasome. Our results provide new insight into the primary substrate specificity of Lon and identify substrates and an inhibitor that will serve as useful tools for dissecting the diverse cellular functions of Lon." @default.
• W2970018255 created "2019-09-05" @default.
• W2970018255 creator A5000997540 @default.
• W2970018255 creator A5005853846 @default.
• W2970018255 creator A5006663325 @default.
• W2970018255 creator A5013392613 @default.
• W2970018255 creator A5060005408 @default.
• W2970018255 creator A5083403212 @default.
• W2970018255 date "2019-08-29" @default.
• W2970018255 modified "2023-10-10" @default.
• W2970018255 title "Leveraging Peptide Substrate Libraries to Design Inhibitors of Bacterial Lon Protease" @default.
• W2970018255 cites W1484510333 @default.
• W2970018255 cites W1514880127 @default.
• W2970018255 cites W1515015726 @default.
• W2970018255 cites W1549764679 @default.
• W2970018255 cites W1577946130 @default.
• W2970018255 cites W1623075183 @default.
• W2970018255 cites W1643821110 @default.
• W2970018255 cites W1659370522 @default.
• W2970018255 cites W1965575777 @default.
• W2970018255 cites W1974053222 @default.
• W2970018255 cites W1975487363 @default.
• W2970018255 cites W1979459698 @default.
• W2970018255 cites W1983439962 @default.
• W2970018255 cites W2001611182 @default.
• W2970018255 cites W2003546739 @default.
• W2970018255 cites W2007577648 @default.
• W2970018255 cites W2036699296 @default.
• W2970018255 cites W2038260155 @default.
• W2970018255 cites W2042185003 @default.
• W2970018255 cites W2045645002 @default.
• W2970018255 cites W2049171279 @default.
• W2970018255 cites W2054588306 @default.
• W2970018255 cites W2054934898 @default.
• W2970018255 cites W2057700578 @default.
• W2970018255 cites W2067194257 @default.
• W2970018255 cites W2072831151 @default.
• W2970018255 cites W2087450076 @default.
• W2970018255 cites W2100365268 @default.
• W2970018255 cites W2101677900 @default.
• W2970018255 cites W2101973479 @default.
• W2970018255 cites W2105988740 @default.
• W2970018255 cites W2106461141 @default.
• W2970018255 cites W2111967267 @default.
• W2970018255 cites W2119349093 @default.
• W2970018255 cites W2120263648 @default.
• W2970018255 cites W2121238870 @default.
• W2970018255 cites W2133509684 @default.
• W2970018255 cites W2135133274 @default.
• W2970018255 cites W2137951835 @default.
• W2970018255 cites W2137956358 @default.
• W2970018255 cites W2151706289 @default.
• W2970018255 cites W2193963378 @default.
• W2970018255 cites W2243666887 @default.
• W2970018255 cites W2256548132 @default.
• W2970018255 cites W2330549095 @default.
• W2970018255 cites W2444473506 @default.
• W2970018255 cites W2461569323 @default.
• W2970018255 cites W2462674314 @default.
• W2970018255 cites W2467964007 @default.
• W2970018255 cites W2561726920 @default.
• W2970018255 cites W2570942072 @default.
• W2970018255 cites W2586386056 @default.
• W2970018255 cites W2589262588 @default.
• W2970018255 cites W2775828058 @default.
• W2970018255 cites W2782704297 @default.
• W2970018255 cites W2793632061 @default.
• W2970018255 cites W2799997715 @default.
• W2970018255 cites W2806316194 @default.
• W2970018255 cites W2886849711 @default.
• W2970018255 cites W2889984933 @default.
• W2970018255 cites W2898437343 @default.
• W2970018255 cites W2917276375 @default.
• W2970018255 cites W2940117744 @default.
• W2970018255 cites W38763105 @default.
• W2970018255 cites W4230449206 @default.
• W2970018255 doi "https://doi.org/10.1021/acschembio.9b00529" @default.
• W2970018255 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6858493" @default.
• W2970018255 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31464417" @default.
• W2970018255 hasPublicationYear "2019" @default.
• W2970018255 type Work @default.
• W2970018255 sameAs 2970018255 @default.
• W2970018255 citedByCount "10" @default.
• W2970018255 countsByYear W29700182552019 @default.
• W2970018255 countsByYear W29700182552020 @default.
• W2970018255 countsByYear W29700182552021 @default.
• W2970018255 countsByYear W29700182552022 @default.
• W2970018255 countsByYear W29700182552023 @default.
• W2970018255 crossrefType "journal-article" @default.
• W2970018255 hasAuthorship W2970018255A5000997540 @default.
• W2970018255 hasAuthorship W2970018255A5005853846 @default.
• W2970018255 hasAuthorship W2970018255A5006663325 @default.
• W2970018255 hasAuthorship W2970018255A5013392613 @default.
• W2970018255 hasAuthorship W2970018255A5060005408 @default.
• W2970018255 hasAuthorship W2970018255A5083403212 @default.
• W2970018255 hasBestOaLocation W29700182552 @default.
• W2970018255 hasConcept C104317684 @default.
• W2970018255 hasConcept C167625842 @default.

• next