Matches in SemOpenAlex for { <https://semopenalex.org/work/W2970032913> ?p ?o ?g. }
- W2970032913 abstract "A vaccine is still urgently needed to overcome the hepatitis C virus (HCV) epidemic. It is estimated that 1.75 million new HCV infections occur each year, many of which will go undiagnosed and untreated. Untreated HCV can lead to continued spread of the disease, progressive liver fibrosis, cirrhosis, and eventually, end-stage liver disease and/or hepatocellular carcinoma (HCC). Previously, our 1a E1/E2 glycoprotein vaccine was shown to elicit broadly cross-neutralizing antibodies; however, there remains variation in the effectiveness of these antibodies against different HCV genotypes. In this study, we investigated determinants of differential neutralization sensitivity between two highly related genotype 2a isolates, J6 and JFH-1. Our data indicate that the HVR1 region determines neutralization sensitivity to vaccine antisera through modulation of sensitivity to antibodies and interactions with SR-B1. Our results provide additional insight into optimizing a broadly neutralizing HCV vaccine." @default.
- W2970032913 created "2019-09-05" @default.
- W2970032913 creator A5006553169 @default.
- W2970032913 creator A5013323616 @default.
- W2970032913 creator A5013826157 @default.
- W2970032913 creator A5016536584 @default.
- W2970032913 creator A5022087885 @default.
- W2970032913 creator A5030872632 @default.
- W2970032913 creator A5037267389 @default.
- W2970032913 creator A5056248574 @default.
- W2970032913 creator A5071436380 @default.
- W2970032913 creator A5073147489 @default.
- W2970032913 creator A5076629111 @default.
- W2970032913 creator A5084661996 @default.
- W2970032913 creator A5090612228 @default.
- W2970032913 date "2019-11-15" @default.
- W2970032913 modified "2023-10-13" @default.
- W2970032913 title "A Recombinant Hepatitis C Virus Genotype 1a E1/E2 Envelope Glycoprotein Vaccine Elicits Antibodies That Differentially Neutralize Closely Related 2a Strains through Interactions of the N-Terminal Hypervariable Region 1 of E2 with Scavenger Receptor B1" @default.
- W2970032913 cites W1963707175 @default.
- W2970032913 cites W1967491261 @default.
- W2970032913 cites W1973027060 @default.
- W2970032913 cites W1978916431 @default.
- W2970032913 cites W1979003966 @default.
- W2970032913 cites W1997677874 @default.
- W2970032913 cites W2000782434 @default.
- W2970032913 cites W2003928321 @default.
- W2970032913 cites W2008240902 @default.
- W2970032913 cites W2015489330 @default.
- W2970032913 cites W2017775841 @default.
- W2970032913 cites W2022687771 @default.
- W2970032913 cites W2028757382 @default.
- W2970032913 cites W2030464734 @default.
- W2970032913 cites W2031004199 @default.
- W2970032913 cites W2043080047 @default.
- W2970032913 cites W2045065319 @default.
- W2970032913 cites W2061343285 @default.
- W2970032913 cites W2064778609 @default.
- W2970032913 cites W2068228603 @default.
- W2970032913 cites W2077103006 @default.
- W2970032913 cites W2077827918 @default.
- W2970032913 cites W2078591526 @default.
- W2970032913 cites W2086853864 @default.
- W2970032913 cites W2095641332 @default.
- W2970032913 cites W2096347191 @default.
- W2970032913 cites W2101494860 @default.
- W2970032913 cites W2102253058 @default.
- W2970032913 cites W2106399441 @default.
- W2970032913 cites W2108340362 @default.
- W2970032913 cites W2108463852 @default.
- W2970032913 cites W2118422968 @default.
- W2970032913 cites W2119428549 @default.
- W2970032913 cites W2120925998 @default.
- W2970032913 cites W2122043154 @default.
- W2970032913 cites W2131143399 @default.
- W2970032913 cites W2133036275 @default.
- W2970032913 cites W2141398361 @default.
- W2970032913 cites W2144805869 @default.
- W2970032913 cites W2147126871 @default.
- W2970032913 cites W2150983148 @default.
- W2970032913 cites W2153130425 @default.
- W2970032913 cites W2160174559 @default.
- W2970032913 cites W2161094955 @default.
- W2970032913 cites W2166959492 @default.
- W2970032913 cites W2167714763 @default.
- W2970032913 cites W2169375105 @default.
- W2970032913 cites W2172176008 @default.
- W2970032913 cites W2218122840 @default.
- W2970032913 cites W2269975638 @default.
- W2970032913 cites W2335913920 @default.
- W2970032913 cites W2345775285 @default.
- W2970032913 cites W2462414039 @default.
- W2970032913 cites W2512992773 @default.
- W2970032913 cites W2519857486 @default.
- W2970032913 cites W2520597593 @default.
- W2970032913 cites W2533264018 @default.
- W2970032913 cites W2567980438 @default.
- W2970032913 cites W2590432698 @default.
- W2970032913 cites W2591088906 @default.
- W2970032913 cites W2591375730 @default.
- W2970032913 cites W2594626196 @default.
- W2970032913 cites W2605110848 @default.
- W2970032913 cites W2605644052 @default.
- W2970032913 cites W2605830903 @default.
- W2970032913 cites W2750028296 @default.
- W2970032913 cites W2789618179 @default.
- W2970032913 cites W2793690257 @default.
- W2970032913 cites W2943791765 @default.
- W2970032913 doi "https://doi.org/10.1128/jvi.00810-19" @default.
- W2970032913 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6819942" @default.
- W2970032913 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31462563" @default.
- W2970032913 hasPublicationYear "2019" @default.
- W2970032913 type Work @default.
- W2970032913 sameAs 2970032913 @default.
- W2970032913 citedByCount "13" @default.
- W2970032913 countsByYear W29700329132020 @default.
- W2970032913 countsByYear W29700329132021 @default.
- W2970032913 countsByYear W29700329132022 @default.
- W2970032913 countsByYear W29700329132023 @default.
- W2970032913 crossrefType "journal-article" @default.
- W2970032913 hasAuthorship W2970032913A5006553169 @default.