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- W2970033143 abstract "Abnormal regulation and expression of microRNAs (miRNAs) has been documented in various diseases including cancer. The miRNA let-7 (MIRLET7) family controls developmental timing and differentiation. Let-7 loss contributes to carcinogenesis via an increase in its target oncogenes and stemness factors. Let-7 targets include genes regulating the cell cycle, cell signaling, and maintenance of differentiation. It is categorized as a tumor suppressor because it reduces cancer aggressiveness, chemoresistance, and radioresistance. However, in rare situations let-7 acts as an oncogene, increasing cancer migration, invasion, chemoresistance, and expression of genes associated with progression and metastasis. Here, we review let-7 function as tumor suppressor and oncogene, considering let-7 as a potential diagnostic and prognostic marker, and a therapeutic target for cancer treatment. We explain the complex regulation and function of different let-7 family members, pointing to abnormal processes involved in carcinogenesis. Let-7 is a promising option to complement conventional cancer therapy, but requires a tumor specific delivery method to avoid toxicity. While let-7 therapy is not yet established, we make the case that assessing its tumor presence is crucial when choosing therapy. Clinical data demonstrate that let-7 can be used as a biomarker for rational precision medicine decisions, resulting in improved patient survival." @default.
- W2970033143 created "2019-09-05" @default.
- W2970033143 creator A5002611376 @default.
- W2970033143 creator A5008787592 @default.
- W2970033143 creator A5037474578 @default.
- W2970033143 creator A5079369897 @default.
- W2970033143 date "2019-08-28" @default.
- W2970033143 modified "2023-10-11" @default.
- W2970033143 title "<i>Let</i>‐<i>7</i>as biomarker, prognostic indicator, and therapy for precision medicine in cancer" @default.
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