FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2970040102> ?p ?o ?g. }

• W2970040102 endingPage "110576" @default.
• W2970040102 startingPage "110576" @default.
• W2970040102 abstract "High-fat diet (HFD) consumption caused metabolic disturbance, gut dysbiosis, brain pathology, microglia hyperactivity, and cognitive decline. However, the exact timeline of these abnormalities following HFD consumption is still elusive. Therefore, the aim of this study was to test the hypothesis that gut dysbiosis, peripheral inflammation, and peripheral insulin resistance occur before the brain inflammatory response, hippocampal synaptic dysplasticity, oxidative stress, apoptosis, and cognitive impairment in HFD-fed rats. Male Wistar rats received either a normal diet or an HFD for 2, 8, 12, 20, or 40 wk. At the end of each time point, cognitive functions and metabolic parameters were determined. Gut microbiota, brain immune cell activity, amyloid-β level, microglia morphology, hippocampal reactive oxygen species and apoptosis, hippocampal synaptic plasticity, and dendritic spine density were measured. We found that HFD-fed rats developed gut dysbiosis at week 2 and peripheral insulin resistance at week 8. Rats fed an HFD for 12 wk displayed hippocampal synaptic dysplasticity, decreased dendritic spine density, an elevation of ionized calcium-binding adapter molecule 1+ cells, increased hippocampal reactive oxygen species levels and hippocampal apoptosis with cognitive decline. The decreased percentage of resident microglia and increased percentage of infiltrated macrophage were observed at weeks 20 and 40. Surprisingly, brain amyloid-β levels were increased after 40 wk of an HFD diet. These findings demonstrated that gut dysbiosis develops in the earliest phase of consumption of an HFD, followed by brain pathology, which leads to cognitive decline in obese insulin-resistant rats. Therefore, an improvement in gut dysbiosis should provide beneficial effects in the prevention of neuropathology and cognitive decline in the obese." @default.
• W2970040102 created "2019-09-05" @default.
• W2970040102 creator A5019018553 @default.
• W2970040102 creator A5024080310 @default.
• W2970040102 creator A5026142449 @default.
• W2970040102 creator A5030219645 @default.
• W2970040102 creator A5032214890 @default.
• W2970040102 creator A5053284900 @default.
• W2970040102 creator A5055084636 @default.
• W2970040102 creator A5063259639 @default.
• W2970040102 creator A5068158378 @default.
• W2970040102 creator A5074956117 @default.
• W2970040102 date "2020-01-01" @default.
• W2970040102 modified "2023-10-10" @default.
• W2970040102 title "Gut dysbiosis develops before metabolic disturbance and cognitive decline in high-fat diet–induced obese condition" @default.
• W2970040102 cites W1647551795 @default.
• W2970040102 cites W1915977580 @default.
• W2970040102 cites W1964244234 @default.
• W2970040102 cites W1971415551 @default.
• W2970040102 cites W1973927723 @default.
• W2970040102 cites W1984551681 @default.
• W2970040102 cites W1986219537 @default.
• W2970040102 cites W1991043494 @default.
• W2970040102 cites W1994580609 @default.
• W2970040102 cites W1998596632 @default.
• W2970040102 cites W2000222209 @default.
• W2970040102 cites W2008527880 @default.
• W2970040102 cites W2013157141 @default.
• W2970040102 cites W2031382376 @default.
• W2970040102 cites W2047021244 @default.
• W2970040102 cites W2052179757 @default.
• W2970040102 cites W2063979477 @default.
• W2970040102 cites W2075313898 @default.
• W2970040102 cites W2078621811 @default.
• W2970040102 cites W2081965230 @default.
• W2970040102 cites W2086648828 @default.
• W2970040102 cites W2094109323 @default.
• W2970040102 cites W2108880048 @default.
• W2970040102 cites W2110936821 @default.
• W2970040102 cites W2113828666 @default.
• W2970040102 cites W2117186800 @default.
• W2970040102 cites W2127612581 @default.
• W2970040102 cites W2128833728 @default.
• W2970040102 cites W2131536322 @default.
• W2970040102 cites W21411052 @default.
• W2970040102 cites W2143642040 @default.
• W2970040102 cites W2146164834 @default.
• W2970040102 cites W2159822434 @default.
• W2970040102 cites W2167591869 @default.
• W2970040102 cites W2169057285 @default.
• W2970040102 cites W2212127474 @default.
• W2970040102 cites W2323267661 @default.
• W2970040102 cites W2344397802 @default.
• W2970040102 cites W2405411748 @default.
• W2970040102 cites W2417777372 @default.
• W2970040102 cites W2495439066 @default.
• W2970040102 cites W2508213551 @default.
• W2970040102 cites W2511800558 @default.
• W2970040102 cites W2513082925 @default.
• W2970040102 cites W2528438579 @default.
• W2970040102 cites W2590486787 @default.
• W2970040102 cites W2620098478 @default.
• W2970040102 cites W2781938656 @default.
• W2970040102 cites W2783085016 @default.
• W2970040102 cites W2784170557 @default.
• W2970040102 cites W2791051997 @default.
• W2970040102 cites W2793873186 @default.
• W2970040102 cites W2795999744 @default.
• W2970040102 cites W2802616779 @default.
• W2970040102 cites W2804667375 @default.
• W2970040102 cites W2894735861 @default.
• W2970040102 cites W2903363645 @default.
• W2970040102 cites W2909487462 @default.
• W2970040102 doi "https://doi.org/10.1016/j.nut.2019.110576" @default.
• W2970040102 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31580986" @default.
• W2970040102 hasPublicationYear "2020" @default.
• W2970040102 type Work @default.
• W2970040102 sameAs 2970040102 @default.
• W2970040102 citedByCount "47" @default.
• W2970040102 countsByYear W29700401022019 @default.
• W2970040102 countsByYear W29700401022020 @default.
• W2970040102 countsByYear W29700401022021 @default.
• W2970040102 countsByYear W29700401022022 @default.
• W2970040102 countsByYear W29700401022023 @default.
• W2970040102 crossrefType "journal-article" @default.
• W2970040102 hasAuthorship W2970040102A5019018553 @default.
• W2970040102 hasAuthorship W2970040102A5024080310 @default.
• W2970040102 hasAuthorship W2970040102A5026142449 @default.
• W2970040102 hasAuthorship W2970040102A5030219645 @default.
• W2970040102 hasAuthorship W2970040102A5032214890 @default.
• W2970040102 hasAuthorship W2970040102A5053284900 @default.
• W2970040102 hasAuthorship W2970040102A5055084636 @default.
• W2970040102 hasAuthorship W2970040102A5063259639 @default.
• W2970040102 hasAuthorship W2970040102A5068158378 @default.
• W2970040102 hasAuthorship W2970040102A5074956117 @default.
• W2970040102 hasConcept C126322002 @default.
• W2970040102 hasConcept C134018914 @default.
• W2970040102 hasConcept C148762608 @default.

• next