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- W2970097997 endingPage "4278" @default.
- W2970097997 startingPage "4278" @default.
- W2970097997 abstract "The treatment of cancer has been slowly but steadily progressing during the last fifty years. Some tumors with a high mortality in the past are curable nowadays. However, there is one striking exception: glioblastoma multiforme. No real breakthrough has been hitherto achieved with this tumor with ominous prognosis and very short survival. Glioblastomas, being highly glycolytic malignancies are strongly pH-dependent and driven by the sodium hydrogen exchanger 1 (NHE1) and other proton (H+) transporters. Therefore, this is one of those pathologies where the lessons recently learnt from the new pH-centered anticancer paradigm may soon bring a promising change to treatment. This contribution will discuss how the pH-centric molecular, biochemical and metabolic perspective may introduce some urgently needed and integral novel treatments. Such a prospective therapeutic approach for malignant brain tumors is developed here, either to be used alone or in combination with more standard therapies." @default.
- W2970097997 created "2019-09-05" @default.
- W2970097997 creator A5020257113 @default.
- W2970097997 creator A5036896955 @default.
- W2970097997 creator A5076488347 @default.
- W2970097997 creator A5088367467 @default.
- W2970097997 date "2019-09-01" @default.
- W2970097997 modified "2023-09-27" @default.
- W2970097997 title "Hydrogen Ion Dynamics of Cancer and a New Molecular, Biochemical and Metabolic Approach to the Etiopathogenesis and Treatment of Brain Malignancies" @default.
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