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• W2970155980 abstract "Abstract Background Interferon‐γ ( IFN ‐γ) and interleukin‐12 ( IL ‐12) play a crucial role in the defense against mycobacteria, and in the response to bacillus Calmette–Guérin ( BCG ) vaccination. We have previously reported clinical and outcome data of 222 BCG osteitis cases diagnosed in 1960–1988 in Finland. The immunological and genetic reports have been based on 132 blood samples obtained in 2007–2008. Methods We compared IFN γ rs2430561 and rs35314021 , IL 12A rs568408 and rs2243115 , and IL 12B rs3212227 single‐nucleotide polymorphisms ( SNP ) between 132 BCG osteitis patients and 99 population‐based controls. In addition, stimulated production of IFN ‐γ and IL ‐12 in cell culture was evaluated in relation to the presence of IFN γ and IL 12 wild versus variant genotypes, respectively. Results The distributions of IFN γ rs2430561 , IFN γ rs35314021 , IL 12A rs568408 , IL 12A rs2243115 and IL 12B rs3212227 SNP did not differ between BCG osteitis patients and Finnish population‐based controls. For IFN γ rs2430561 , IFN γ rs35314021 and IL 12A rs2243115 , the negative result was confirmed by comparing the minor allele frequencies ( MAF ) in BCG osteitis cases with those in the publicly available genome aggregation database, including data for 3,472 Finnish persons. Instead, for IL 12A rs568408 and IL 12B rs3212227 , the comparison of MAF in BCG osteitis cases with those in population‐based and in aggregation‐based controls gave conflicting results. The presence of the wild versus variant genotype had no significant association with IL ‐12 or IFN ‐γ production in BCG ‐stimulated cell cultures. Conclusion IFN γ gene polymorphisms did not show any association with BCG osteitis after newborn vaccination." @default.
• W2970155980 created "2019-09-05" @default.
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• W2970155980 date "2019-10-01" @default.
• W2970155980 modified "2023-10-17" @default.
• W2970155980 title "Interferon‐γ and interleukin‐12 production in relation to gene polymorphisms in bacillus Calmette–Guérin osteitis" @default.
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• W2970155980 doi "https://doi.org/10.1111/ped.13998" @default.
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